GBA Mouse Monoclonal Antibody [Clone ID: OTI1C7]

Specifications

Product Data
Clone Name	OTI1C7
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 40-315 of human GBA (NP_000148) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.5 kDa
Gene Name	glucosylceramidase beta
Database Link	NP_000148 Entrez Gene 14466 MouseEntrez Gene 2629 Human UniProt ID P04062
Background	This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Synonyms	GBA1; GCB; GLUC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

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