bcl 6 (BCL6) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C3]

Specifications

Product Data
Clone Name	OTI1C3
Applications	IHC
Recommend Dilution	IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-300 of human BCL6 (NP_001697) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Gene Name	B-cell CLL/lymphoma 6
Database Link	NP_001697 Entrez Gene 12053 MouseEntrez Gene 303836 RatEntrez Gene 604 Human UniProt ID P41182
Background	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Synonyms	BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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