MAP3K8 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2E3]

Specifications

Product Data
Clone Name	OTI2E3
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 277-461 of human MAP3K8(NP_005195) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	HRP
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52.7 kDa
Gene Name	mitogen-activated protein kinase kinase kinase 8
Database Link	NP_005195 Entrez Gene 26410 MouseEntrez Gene 116596 RatEntrez Gene 1326 Human UniProt ID P41279
Background	This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Synonyms	AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

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