CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: UMAB290]

Specifications

Product Data
Clone Name	UMAB290
Applications	IHC, WB
Recommend Dilution	WB 1:1000, IHC 1:100
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ENG(NP_000109) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	67.78 kDa
Gene Name	endoglin
Database Link	NP_000109 Entrez Gene 2022 Human UniProt ID P17813
Background	This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Synonyms	END; HHT1; ORW1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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