PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: UMAB199]

Specifications

Product Data
Clone Name	UMAB199
Applications	10k-ChIP, IF, IHC, WB
Recommend Dilution	IHC 1:1000, WB 1:500, IF 1:100
Reactivity	Human, Mouse, Dog, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PDCD1 (NP_005009) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5~1.0 mg/ml (Lot Dependent)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29.2 kDa
Gene Name	programmed cell death 1
Database Link	NP_005009 Entrez Gene 18566 MouseEntrez Gene 301626 RatEntrez Gene 486213 DogEntrez Gene 5133 Human UniProt ID Q15116
Background	This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul
Synonyms	CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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