Human Procalcitonin (CALCA) ELISA Kit 1 x 96

Specifications

Product Data
Description	Human Procalcitonin (CALCA) ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	4.5 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	78pg/ml-5000pg/ml
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of Human Procalcitonin
Sensitivity	16.15g/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	Procalcitonin Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human Procalcitonin Standard (250ng/ml)|0.1 mL 100x Biotin conjugated Procalcitonin Detection Antibody|0.12 mL 100x Streptavidin-HRP|0.12 mL Assay Buffer|30 mL Standard &Sample Diluent|30 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer|3 pieces
Background	Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin (CT). It is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. Under normal conditions PCT is cleaved by endopeptidase to form mature hormone calcitonin. During inflammation, expression of PCT is induced by LPS, microbial toxin, or inflammatory mediators such as IL-6 or TNF-α in adipoctyes, but the PCT is not cleaved to produce CT, which results in the increase of PCT level during bacterial infection. PCT has become a marker of bacterial infection. Measurement of PCT can be used as a marker of severe sepsis caused by bacteria, and could help diagnose infectious complications of inflammatory bowel disease. In acute meningitis, serum PCT is useful as a biomarker for sepsis. In addition, PCT is often high in patients with chronic kidney disease and end-stage renal disease. In patients with atherosclerosis or coronary heart disease PCT is also valuable as a prognostic marker as its levels correlate with the severity of the illness.
Gene Symbol	CALCA
Standard Curve	Data image of Human Calcitonin (CALCA) ELISA Kit.

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