Helicobacter pylori CagA ELISA Kit 1 x 96

Specifications

Product Data
Description	Helicobacter pylori CagA ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	3.5 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	31.25-2000pg/ml
Sample Type	Human serum, plasma, fecal extraction sample and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of CagA
Sensitivity	18pg/ml
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	CagA Monoclonal Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant H. Pylori CagA Standard (100ng/ml)|0.1 mL 100x Biotin conjugated CagA Detection Antibody|0.12 mL 100x SA-HRP Conjugate0.12 mL Assay Buffer|40 mL Sample Diluent|30 mL Detection Antibody Diluent 12ml Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer|3 pieces
Background	Helicobacter pylori (H. pylori) is a Gram-negative bacterium causing gastritis, peptic ulcer disease and gastric adenocarcinoma. Although H. pylori could induce strong inflammation, it is not able to clear the bacterium, resulting in persistent infection. Cytotoxin-associated gene A (CagA), one of H. pylori virulence factors, is an effector secreted by the type IV secretion system into gastric epithelial cells, which undergoes tyrosine phosphorylation and activates a series of intracellular signal transduction reactions, resulting in severe tissue inflammation and damage. Some H. pylori strains contain particular pathogenic genes such as CagA, while others lack these genes. The CagA protein of H. pylori has been found to be associated with more severe clinical manifestations. Many studies indicate that CagA of H. pylori plays critical roles in H. pylori-induced gastric inflammation and chronic infection with Helicobacter pylori CagA-positive strains is the strongest risk factor of gastric cancer.
Gene Symbol	CagA
Standard Curve	Data image of Helicobacter pylori CagA ELISA Kit.

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