Antithrombin III (SERPINC1) (NM_000488) Human 3' UTR Clone

Specifications

Product Data
Product Name	Antithrombin III (SERPINC1) (NM_000488) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; THPH7
ACCN	NM_000488
Insert Size	119 bp
Sequence Data	Insert Sequence (showhide) >SC200416 3’UTR clone of NM_000488 The sequence shown below is from the reference sequence of NM_000488. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGCAGAGTAGCCAACCCTTGTGTTAAGTAAAATGTTCTTATTCTTTGCACCTCTTCCTATTTTTGGTTT GTGAACAGAAGTAAAAATAAATACAAACTACTTCCATCTCACATTATAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000488.4
Synonyms	AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; THPH7
Summary	The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]
Locus ID	462
MW	4.5

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