EIF3E (NM_001568) Human 3' UTR Clone

Specifications

Product Data
Product Name	EIF3E (NM_001568) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	eIF3-p46; EIF3-P48; EIF3S6; INT6
ACCN	NM_001568
Insert Size	699 bp
Sequence Data	Insert Sequence (showhide) >SC201408 3’UTR clone of NM_001568 The sequence shown below is from the reference sequence of NM_001568. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGGGCAACTCAAGATTCTGGCTTCTACTGAAGAACCATAAAGAAAAGATGAAAAAAAAAACTATCAAAG AAAGATGAAATAATAAAACTATTATATAAAGGGTGACTTACATTTTGGAAACAACATATTACGTATAAA TTTTGAAGAATTGGAATAAAATTGATTCATTTTATCTTGCTGTCAGTTTTCTTGCATGTGCAAGTTTGT GTTTTTTTAACTTTCTTTTTTGGAATAATTATATTCAGAGGAATTTGCAAAAATAGTACAGAGAAGTCC CTGTAGGCTGAACCCTGTTTCCCTCAATTTTTTCACTTTGTCTTACTATGGTACAGTATCAAAACCAGG ATGTTGACATTGGTACAATGTGTGTACAAATAGCTCCCTACCATTTTATCACGTGTAGATTTGTGTAAC CATCACTGCAGCCAAGATAGAGAACTATCATCATGATCTCCCTCATGCTACCTTTTTGTAGCCATACCT ACTCCCAACCAACTCTAACCCTAGGAACCACTAATCTGTTCCTCATCGCTATATTTTGTCATTATGAGA ATGTTATATAAATGGAATTACATAATACACAACCTTTGAGATTAGCTTTTTTCATTCATCACAATGCTC TTGAGAGCCATCCAAGTTGAGAGATAGATATATATATATATATGATCAGTAGTTAATTCCTTTTTTATT GCCAAATAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001568.3
Synonyms	eIF3-p46; EIF3-P48; EIF3S6; INT6
Summary	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).[UniProtKB/Swiss-Prot Function]
Locus ID	3646
MW	27.6

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