TLR3 (NM_003265) Human 3' UTR Clone

Specifications

Product Data
Product Name	TLR3 (NM_003265) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD283; IIAE2
ACCN	NM_003265
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC202930 3’UTR clone of NM_003265 The sequence shown below is from the reference sequence of NM_003265. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCACTTGGATCCAAAAACTCTGTACATTAAATTTATTTAAATATTCAATTAGCAAAGGAGAAACTTTCT CAATTTAAAAAGTTCTATGGCAAATTTAAGTTTTCCATAAAGGTGTTATAATTTGTTTATTCATATTTG TAAATGATTATATTCTATCACAATTACATCTCTTCTAGGAAAATGTGTCTCCTTATTTCAGGCCTATTT TTGACAATTGACTTAATTTTACCCAAAATAAAACATATAAGCACGTAAGAACATTGTCTACTGATTAAT ATACAATCAGCCACTGAGCCTATGACAGCTTAAGGAGTTTGAAAACATTCCTCATTTTAAGAAAAGTTA GAGGTATATGAGGGTTTGTGATGATCTTTTTGTATTTTGGATGCACTTAGAATGAAAGATAATTGTTTC AATGGGTATAATGCTATTTCCTTTGTAAAAGAGTAAAATATATACCCATATTTTTAACAAGTTTAATTA CAGTATTTTTTCAATGGAAAAACTTTGTATTTTAGTAAGTACTTGTCTCAGTGTTGACTTTGTTAAATG TTAAATATTTTTTAATATACATACCCAAGGGCAGAAAACATTTGCAATTCATTTTTATTAGTTAATGAG ATGATTATTTGAATGAATATTGACTTGTATTTTCCTGAGATTATGAGTTTCTGCTGTGGGAGGGTGGAA ACAATTCTCTTACTAAAAGTATTGTAGGCAGGCTTGCTTTCTGAAGGCTAATCACTATTTGGCTTTGTG GAAACAGAACTTTCCTCCCATGGTCACAGACTCAGGAGATGGCGTTGGCAAAATCACTTGGTCCCACTG GGATTCTTTGACTCCTGATCTTGAAAATTATGATAATAAATGCATCTTAGATATTCCTATGTAATTAGT GATGATGATCGCTGTATAATATATTCAAAGGAATGTATTATTTTACCATAAAATAATGTGCTACGCATA AGGTAGTCCTTATCTAGAAAGACTATTTTTATTTTTGTTTTTTTGTTTGTTTGTTTTTTATTTGTTTGT TTTTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTTCAGTGGTCCAACCTCGGCCCACCGCAACC TCCACCTCTGAGTTCAAGCTATTCTCCTGCCTCAGCCACCCGAGTAGCTGGGATTACAGGCACATGCCA CCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGA ACTCCTGACCTCAAGTGATCCTCTCGCCTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCG CGCCCCGCCTTTTTATTTTGTTTTACAATACAACAAAAAATTTTTAGTTTTACAATAAAAGAGAATCTG ATTATTGGAAATAGACCTGAATAGCTTTTTGAAATATTTATAGTTCTAGTATTTAAAGAGAAACCTGAA ATTATAAAGCTGAGTTAATTTCTATACCTGAAATGTTCATTTGTCTGCTGAATTCAGGGAGCATTTGAG ATGTCACATTTTGGAACTTTGATTTAAATAGTTCAGTATTCCCAAGGCTGAGTTCCATGACCCTGGAAT GAGAAATATCCACTGTACCTCTGGTTCTGAAGAGTCTATAGTCGGCCAACACTGTGAATGTGTGGAGGA CTAATTGTCACTTTCATGTTATTTGCCACCCTGACAGCTGAGACACTGCTTTTCAGCATTTTAGTTAAG ATTTGCTTTTTAACTGTGCAATAATCATTTTATTTTGGCATTATAAAATAAAAATCACAACTTCTGCTT TTCTTATATGCTTTGTGTGTTATCACACAAATATTCTCAAATATTCATAAGATATTTTAAATAAATCAT TGTGAATTAGTCAATATATCAAGTTGCTTAATATGTCATATATCAATGCTATTTAATATATAATATCTA TATTTAATATATTGATATGTTACTGGTGGAGAGTGTCCAGGTTCTTGGTGCTTTGAACAAGGAATTGG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003265.3
Synonyms	CD283; IIAE2
Summary	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
Locus ID	7098
MW	77.7

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