Angiotensin Converting Enzyme 1 (ACE) (NM_000789) Human 3' UTR Clone

Specifications

Product Data
Product Name	Angiotensin Converting Enzyme 1 (ACE) (NM_000789) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ACE1; CD143; DCP; DCP1
ACCN	NM_000789
Insert Size	1037 bp
Sequence Data	Insert Sequence (showhide) >SC203117 3’UTR clone of NM_000789 The sequence shown below is from the reference sequence of NM_000789. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGCTCCGAGGTGGAGCTGAGACACTCCTGAGGTGACCCGGCTGGGTCGGCCCTGCCCAAGGGCCTCCCA CCAGAGACTGGGATGGGAACACTGGTGGGCAGCTGAGGACACACCCCACACCCCAGCCCACCCTGCTCC TCCTGCCCTGTCCCTGTCCCCCTCCCCTCCCAGTCCTCCAGACCACCAGCCGCCCCAGCCCCTTCTCCC AGCACACGGCTGCCTGACACTGAGCCCCACCTCTCCAAGTCTCTCTGTGAATACAATTAAAGGTCCTGC CCTCCCCATCTGAGTCTGTGTCCCTCACAGGGAAGCCAGGGACAGGGACAGGCTGCTTTCCTGCCTCCT GGCAGTCAAGTGGGTCCCGTTACTAGGTTTGTTCCTCCATCCTCCTTCAGGAGCCGGGGAGGATCCCCA GAGCTCTGCCCCAGCACCTCCTGGCGCTGGCGCCTGTCTTCCCTCCAGCCCAGGCAGCCCGCCACTGTC CTGCCACCGCAGGCAGCCCCTGTCTGGCCCAAGCACTGACCCACGCGGACTCTGGGAAGCAGACATCCT GGGCTGCTGGCCTCACATTTCCACTGGCAGTGGAGCCTTTCCCTGCTCCACAAATGGCCAGGTCCCCCC AGGGGAAGGCTTCCGGCTGTTATCGGCTGCCTCAGGGGGCGAGTACCTTGGAGGGCCTGCTTCAAGGAG GGTGCCCCCTGGAGGGCACACACCAGCCTAGTGCTTACCTTGGCTCCTGCCTGTACCAGCTCCATGACT CTGCTCGGGTGAACAGCCTTGGCTCTCAGACAGCCATTCTAACACTGCCAGTGCAGAGGGGCCTCAGAC GCTGGAGTGTAGCAGTGGCTGCACCTGCACAGGGATTAGCTGCCAGCAGCCACCCTGCTGGCGTCCCAG CACACACCTCCTCACTCCCTGCATTGGAGGGAGTGTCATTTTAAGGGACATTTTTATGACTTTTATGTG TATGTTTATGTAGAAATTTGGAAAATACAGAAAACTGTAAAGAAAATAAAAGCCCTTTATATCAACGTC AA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000789.4
Synonyms	ACE1; CD143; DCP; DCP1
Summary	This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]
Locus ID	1636
MW	37.7

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