NR2F6 (NM_005234) Human 3' UTR Clone

Specifications

Product Data
Product Name	NR2F6 (NM_005234) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	EAR-2; EAR2; ERBAL2
ACCN	NM_005234
Insert Size	499 bp
Sequence Data	Insert Sequence (showhide) >SC206312 3’UTR clone of NM_005234 The sequence shown below is from the reference sequence of NM_005234. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTCAACTGGCCCTACGGCTCGGGCCAGTGACCATGACGGGGCCACGTGTGCTGTGGCCAGGCCTGCAGA CAGACCTCAAGGGACAGGGAATGCTGAGGCCTCGAGGGGCCTCCCGGGGCCCAGGACTCTGGCTTCTCT CCTCAGACTTCTATTTTTTAAAGACTGTGAAATGTTTGTCTTTTCTGTTTTTTAAATGATCATGAAACC AAAAAGAGACTGATCATCCAGGCCTCAGCCTCATCCTCCCCAGGACCCCTGTCCAGGATGGAGGGTCCA ATCCTAGGACAGCCTTGTTCCTCAGCACCCCTAGCATGAACTTGTGGGATGGTGGGGTTGGCTTCCCTG GCATGATGGACAAAGGCCTGGCGTCGGCCAGAGGGGCTGCTCCAGTGGGCAGGGGTAGCTAGCGTGTGC CAGGCAGATCCTCTGGACACGTAACCTATGTCAGACACTACATGATGACTCAAGGCCAATAATAAAGAC ATTTCCTACCTGCACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005234.4
Synonyms	EAR-2; EAR2; ERBAL2
Summary	Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).[UniProtKB/Swiss-Prot Function]
Locus ID	2063
MW	18

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