MLKL (NM_001142497) Human 3' UTR Clone

Specifications

Product Data
Product Name	MLKL (NM_001142497) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hMLKL
ACCN	NM_001142497
Insert Size	679 bp
Sequence Data	Insert Sequence (showhide) >SC208649 3’UTR clone of NM_001142497 The sequence shown below is from the reference sequence of NM_001142497. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTAAAGAAACTCTCCACCTTTTCTAAGTAGTGTATCAAAATCTAAACCAAGGAGTCTCTGGACAAGAAG CTGGGAGAGGCACAAACTGGACATCTCTCTCTCTCATATCCTTCGGCATTGGGTTATCTATGGGTGCAA GGAGTGGGCACGCTTCTCTGTTACAAATAGAAAACGATTCCAGTCATACAGGACACATCCCACTCCAAA TGATATTTCCAAAAACATACCTCTGACAGTAACTTTGATAGATGGTTTGTCAAATGTATCTTTCTGGGT ATCCACACCTCTTGGCAATGAAATTTGCAGCTCCTCCCTTCCATAAATGAAGTCTCTTTCCCCACCATT TGAATCTGGGCTGGCACTGTGACTTGATTTGATCAATAGAATGTGGAAGAAGTGACTGTATGCCAGTTC CAAGCCTAGGTTTCAAGAGGCCTTATAAATGTCTGTTGGAACCTTACCCAGCCATGAACATGTTGAGTG AGCATGCTGGAGAATGAGAGACCACATGAAGCAGAAACATGCTTTCCTAGCTGAAGTCATACTAGCCCA ACCAACATGGCAGCTAACACATGAATGAGGCCAATCAAGACCAGAAGAACCACTCAAGCAGATCCCAGC CCAAATTGCCCATTCACACAATCAGGAGCTAAATAAATTACTGTTGTCTTAACACTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001142497.3
Synonyms	hMLKL
Summary	This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Locus ID	197259
MW	25.4

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