NKG2D (KLRK1) (NM_007360) Human 3' UTR Clone

Specifications

Product Data
Product Name	NKG2D (KLRK1) (NM_007360) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD314; D12S2489E; KLR; NKG2-D; NKG2D
ACCN	NM_007360
Insert Size	791 bp
Sequence Data	Insert Sequence (showhide) >SC209788 3’UTR clone of NM_007360 The sequence shown below is from the reference sequence of NM_007360. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ACGTACATCTGCATGCAAAGGACTGTGTAAAGATGATCAACCATCTCAATAAAAGCCAGGAACAGAGAA GAGATTACACCAGCGGTAACACTGCCAACTGAGACTAAAGGAAACAAACAAAAACAGGACAAAATGACC AAAGACTGTCAGATTTCTTAGACTCCACAGGACCAAACCATAGAACAATTTCACTGCAAACATGCATGA TTCTCCAAGACAAAAGAAGAGAGATCCTAAAGGCAATTCAGATATCCCCAAGGCTGCCTCTCCCACCAC AAGCCCAGAGTGGATGGGCTGGGGGAGGGGTGCTGTTTTAATTTCTAAAGGTAGGACCAACACCCAGGG GATCAGTGAAGGAAGAGAAGGCCAGCAGATCACTGAGAGTGCAACCCCACCCTCCACAGGAAATTGCCT CATGGGCAGGGCCACAGCAGAGAGACACAGCATGGGCAGTGCCTTCCCTGCCTGTGGGGGTCATGCTGC CACTTTTAATGGGTCCTCCACCCAACGGGGTCAGGGAGGTGGTGCTGCCCCAGTGGGCCATGATTATCT TAAAGGCATTATTCTCCAGCCTTAAGTAAGATCTTAGGACGTTTCCTTTGCTATGATTTGTACTTGCTT GAGTCCCATGACTGTTTCTCTTCCTCTCTTTCTTCCTTTTGGAATAGTAATATCCATCCTATGTTTGTC CCACTATTGTATTTTGGAAGCACATAACTTGTTTGGTTTCACAGGTTCACAGTTAAGAAGGAATTTTGC CTCTGAATAAATAGAATCTTGAGTCTCATGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_007360.4
Synonyms	CD314; D12S2489E; KLR; NKG2-D; NKG2D
Summary	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Locus ID	22914
MW	30.6

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