RPE65 (NM_000329) Human 3' UTR Clone

Specifications

Product Data
Product Name	RPE65 (NM_000329) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BCO3; LCA2; mRPE65; p63; rd12; RP20; sRPE65
ACCN	NM_000329
Insert Size	984 bp
Sequence Data	Insert Sequence (showhide) >SC211325 3’UTR clone of NM_000329 The sequence shown below is from the reference sequence of NM_000329. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ACCTTTCATGGACTGTTCAAAAAATCTTGAGCATACTCCAGCAAGATATGTTTTTGGTAGCAAAACTGA GAAAATCAGCTTCAGGTCTGCAATCAAATTCTGTTCAATTTTAGCCTGCTATATGTCATGGTTTTAACT TGCAGATGCGCACAATTTTGCAATGTTTTACAGAAAGCACTGAGTTGAGCAAGCAATTCCTTTATTTAA AAAAAAAAGTACGTATTTAGATAATCATACTTCCTCTGTGAGACAGGCCATAACTGAAAAACTCTTAAA TATTTAGCAATCAAATAGGAAATGAATGTGGACTTACTAAATGGCTTTTAATTCCTATTATAAGAGCAT ATTTTAGGTACCTATCTGCTCCAATTATATTTTTAACATTTAAAAACCAAAGTCCTCTACACTTGATTT ATATTATATGTGGCTTTGCTGAGTCAAGGAAGTATCATGCAATAAGGCTTAATTACTAAATGTCAAACC AAACTTTTTCTCAAACCAGGGACTATCATCTAAGATTAATTACAGTAATTATTTTGCGTATACGTAACT GCTCAAAGATTATGAATCTTATGAATGTTAACCTTTCCGTTTATTACAAGCAAGTACTATTATTTCTGA TTTTATAATAAGAAAATCTGTGTTTAATCAACTGAGGCCTCTCAACCAAATAACATCTCAGAGATTAAG TTATATATTAAAAGCTTATGTAACATAAAAGCAAGTACATATAGTAGTGACTATATTTAAAAAAACAGC ATAAAATGCTTAAAAATGTAATATTTACTAAAATCAGATTATGGGATAATGTTGCAGGATTATACTTTA TTGCATCTTTTTTGTTTAATTGTATTTAAGCATTGTGCAATCACTTGGGAAAAATATTAAATTATTAAC ATTGAGGTATTAATACATTTTAAGCCTTTTGTTTTTAAATTTCTTTTCTTCCAGAGATTGTTTAAAAAT AAATATTGACAAAAATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000329.3
Synonyms	BCO3; LCA2; mRPE65; p63; rd12; RP20; sRPE65
Summary	The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
Locus ID	6121
MW	38.7

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