Titin (TTN) (NM_133378) Human 3' UTR Clone

Specifications

Product Data
Product Name	Titin (TTN) (NM_133378) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CMD1G; CMH9; CMPD4; EOMFC; HMERF; LGMD2J; LGMDR10; MYLK5; SALMY; TMD
ACCN	NM_133378
Insert Size	1053 bp
Sequence Data	Insert Sequence (showhide) >SC211883 3’UTR clone of NM_133378 The sequence shown below is from the reference sequence of NM_133378. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ACTGTGAATATACATATTCGATCCATTTAAGAGGGCCTGTGCCCTTATACTCTACACTCATTCTTAACT TTTCGCAAACGTTTCACACGGACTAATCTTTCTGAACTGTAAATATTTAAAGAAAAAAAAGTAGTTTTG TATCAACCTAAATGAGTCAAAGTTCAAAAATATTCATTTCAATCTTTTCATAATTGTTGACCTAAGAAT ATAATACATTTGCTAGTGACATGTACATACTGTATATAGCCGGATTAACGGTTATAAAGTTTTGTACCA TTTATTTTATGACATTTTACAATGTAAGTTTTGAAACTAACTGTTGGTAGGAGAAAGTTTCTTATGGAA CGAATACCCTGCTCAACATTTAATCAATCTTTGTGCCTCAACATACTGTTGATGTCTAAGTATGCCTCA GTGGGTTGAGAAAATCCCCATTGAAGATGTCCTGTCCACCTAAAAGAGAATGATGCTGTGCATATCACT TGATATGTGCACCAATACCTACTGAATCAGAAATGTAAGGCATTGGTGATGTTTGCATTTACCCTCCTG TAAGCAACACTTTAACGTCTTACATTTTCTCTGATGATGTCACACAAAATTATCATGACAAATATTACC AGAGCAAAGTGTAACGGCCAACACTTTGTTCGCTCATTTTACGCTGTCTCTGACATAAGGAGTGCCTGA ATAGCTTGGAAAAGTAACATCTCCTGGCCATCCCTTCATTTAACCAAGCTATTCAAGTATTCCTATGCC AGAGCAGTGCCAACTCTTGGAGGTCCCAGAGTGCAGCCAATGCCTTTGTGTGGTAGTTCTAAATTTTAA TTGCACCTGAAAAACCTGGGCACCTAAGCAATGAGCCACAGCAAAAAGTAAAGAACAACAACAAAATAA AGCTGTTGTTAAATTTTAAACAATATTACTAATTGCCCAAAATGTCAATTTGATGTAGTTCTTTTCATG CAAGTATAAATTCAATTGTTAGTTATAATTGTTGGACCTCCTTGAGATAGTAACAACAAAATAAAGCAA GCTATCTGCACCTCAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_133378.4
Synonyms	CMD1G; CMH9; CMPD4; EOMFC; HMERF; LGMD2J; LGMDR10; MYLK5; SALMY; TMD
Summary	This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Locus ID	7273
MW	40.4

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