RASA1 (NM_002890) Human 3' UTR Clone
CAT#: SC212043
3' UTR clone of RAS p21 protein activator (GTPase activating protein) 1 (RASA1) transcript variant 1 for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
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经常一起买 (2)
Specifications
Product Data | |
Product Name | RASA1 (NM_002890) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASGAP |
ACCN | NM_002890 |
Insert Size | 1063 bp |
Sequence Data |
>SC212043 3’UTR clone of NM_002890
The sequence shown below is from the reference sequence of NM_002890. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGTATACAAAAACCAATGATGTCAGGTAGCAGCCTTCGCCCCAGTGTTCTGCATGGATTCAGCATGTC CAACATGGTAATTCACTTCAGTTTAATGTCTCCTTTGCTCTTGCCAAAAAATAGCACACTTTTCCACAT TCCAGTGATGTGTGAGCTATGCAAACAAAATCCAAGATTCTGCTGGTGAATAACTATGCCAGCAACCTT GTAAGCTATCTGTGCAGGATATTTGCACTATTTCCACATGGAATCAATCTTTAACAACCTCTGAGCCTT GGTGTACAGACCACCTTTCACAAAACGAAATGCTATGACTGTATCTTGATATCTCGAACTTTCAAAATA TATTTTCAGTACACCCAGTTGCCAAAGTTTTGCTGTCTCTTAGAGAAAGAACTATGAAATCAACTGACA AGAAACACATTCTTATTGACAATTGTGTATAACTGGATTGCAGACTGTTCTTACTGTAACTACTTCCTG ATTAGGAATATGACCATTTGACTGTTCAATGATTATTTGTATTTACAGTTTCCAGAGTTTGTCATTATA ATAGGAACAATCTTTGCTGTATACTTTTAAAAAATACTCTGCTATTTCTCTTGCTGGAACTGTTGAAAG AAAATATATAGAATGATCTATTGCTCATCAGCTTTATTTTTTAAACATACGACTTATTTTGTTGAAATT GTCAAAGACTGTATTTAGATCTCATAATGCTTTGTTAAATGTTTACAAGTAAATAGTTTGAATTCAGTA AATATTATTGGTTGTTGTATTGATCAATGCATGTTACCCATTCAACCATTTTATAGACTACCAATTTCT TTTATGTTAACTAGAATGCTTTTGTTAAAAGTTATTTGTTCATTATTTGTGCTACCCCTTTGATTATGC AGACAACCTCATCAGCTGCCTAACTTATCCATCTTTGAACTTCTGACTACTTGTTGTATCTGCTGGATA TTTAGTTCAACTGTATAGTTTTATTTACTTCTGTATGTGTATTTTTGTGAAGTATTCACAAAGGTTAAG TTAAAATAAAACCAAGGGATATCTTGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_002890.3 |
Synonyms | CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASGAP |
Summary | The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012] |
Locus ID | 5921 |
MW | 41.5 |
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