RANKL (TNFSF11) (NM_003701) Human 3' UTR Clone

Specifications

Product Data
Product Name	RANKL (TNFSF11) (NM_003701) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
ACCN	NM_003701
Insert Size	1125 bp
Sequence Data	Insert Sequence (showhide) >SC212508 3’UTR clone of NM_003701 The sequence shown below is from the reference sequence of NM_003701. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGGGCTTTTAAAGTTCGAGATATAGATTGAGCCCCAGTTTTTGGAGTGTTATGTATTTCCTGGATGTTT GGAAACATTTTTTAAAACAAGCCAAGAAAGATGTATATAGGTGTGTGAGACTACTAAGAGGCATGGCCC CAACGGTACACGACTCAGTATCCATGCTCTTGACCTTGTAGAGAACACGCGTATTTACAGCCAGTGGGA GATGTTAGACTCATGGTGTGTTACACAATGGTTTTTAAATTTTGTAATGAATTCCTAGAATTAAACCAG ATTGGAGCAATTACGGGGTGACCTTATGAGAAACTGCATGTGGGCTATGGGAGGGGTTGGTCCCTGGTC ATGTGCCCCTTCGCAGCTGAAGTGGAGAGGGTGTCATCTAGCGCAATTGAAGGATCATCTGAAGGGGCA AATTCTTTTGAATTGTTACATCATGCTGGAACCTGCAAAAAATACTTTTTCTAATGAGGAGAGAAAATA TATGTATTTTTATATAATATCTAAAGTTATATTTCAGATGTAATGTTTTCTTTGCAAAGTATTGTAAAT TATATTTGTGCTATAGTATTTGATTCAAAATATTTAAAAATGTCTTGCTGTTGACATATTTAATGTTTT AAATGTACAGACATATTTAACTGGTGCACTTTGTAAATTCCCTGGGGAAAACTTGCAGCTAAGGAGGGG AAAAAAATGTTGTTTCCTAATATCAAATGCAGTATATTTCTTCGTTCTTTTTAAGTTAATAGATTTTTT CAGACTTGTCAAGCCTGTGCAAAAAAATTAAAATGGATGCCTTGAATAATAAGCAGGATGTTGGCCACC AGGTGCCTTTCAAATTTAGAAACTAATTGACTTTAGAAAGCTGACATTGCCAAAAAGGATACATAATGG GCCACTGAAATCTGTCAAGAGTAGTTATATAATTGTTGAACAGGTGTTTTTCCACAAGTGCCGCAAATT GTACCTTTTTTGTTTTTTCAAAATAGAAAAGTTATTAGTGGTTTATCAGCAAAAAAGTCCAATTTTAAT TTAGTAAATGTTATCTTATACTGTACAATAAAAACATTGCCTTTGAATGTTAATTTTTTGGTACAAAAA TAAATTTATATGAAAACCTGC AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites	SgfI-RsrII
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003701.4
Synonyms	CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
Summary	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Locus ID	8600
MW	43.1

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.