RANKL (TNFSF11) (NM_003701) Human 3' UTR Clone
CAT#: SC212508
3' UTR clone of tumor necrosis factor (ligand) superfamily member 11 (TNFSF11) transcript variant 1 for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
Product images
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经常一起买 (2)
Specifications
Product Data | |
Product Name | RANKL (TNFSF11) (NM_003701) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE |
ACCN | NM_003701 |
Insert Size | 1125 bp |
Sequence Data |
>SC212508 3’UTR clone of NM_003701
The sequence shown below is from the reference sequence of NM_003701. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGGGCTTTTAAAGTTCGAGATATAGATTGAGCCCCAGTTTTTGGAGTGTTATGTATTTCCTGGATGTTT GGAAACATTTTTTAAAACAAGCCAAGAAAGATGTATATAGGTGTGTGAGACTACTAAGAGGCATGGCCC CAACGGTACACGACTCAGTATCCATGCTCTTGACCTTGTAGAGAACACGCGTATTTACAGCCAGTGGGA GATGTTAGACTCATGGTGTGTTACACAATGGTTTTTAAATTTTGTAATGAATTCCTAGAATTAAACCAG ATTGGAGCAATTACGGGGTGACCTTATGAGAAACTGCATGTGGGCTATGGGAGGGGTTGGTCCCTGGTC ATGTGCCCCTTCGCAGCTGAAGTGGAGAGGGTGTCATCTAGCGCAATTGAAGGATCATCTGAAGGGGCA AATTCTTTTGAATTGTTACATCATGCTGGAACCTGCAAAAAATACTTTTTCTAATGAGGAGAGAAAATA TATGTATTTTTATATAATATCTAAAGTTATATTTCAGATGTAATGTTTTCTTTGCAAAGTATTGTAAAT TATATTTGTGCTATAGTATTTGATTCAAAATATTTAAAAATGTCTTGCTGTTGACATATTTAATGTTTT AAATGTACAGACATATTTAACTGGTGCACTTTGTAAATTCCCTGGGGAAAACTTGCAGCTAAGGAGGGG AAAAAAATGTTGTTTCCTAATATCAAATGCAGTATATTTCTTCGTTCTTTTTAAGTTAATAGATTTTTT CAGACTTGTCAAGCCTGTGCAAAAAAATTAAAATGGATGCCTTGAATAATAAGCAGGATGTTGGCCACC AGGTGCCTTTCAAATTTAGAAACTAATTGACTTTAGAAAGCTGACATTGCCAAAAAGGATACATAATGG GCCACTGAAATCTGTCAAGAGTAGTTATATAATTGTTGAACAGGTGTTTTTCCACAAGTGCCGCAAATT GTACCTTTTTTGTTTTTTCAAAATAGAAAAGTTATTAGTGGTTTATCAGCAAAAAAGTCCAATTTTAAT TTAGTAAATGTTATCTTATACTGTACAATAAAAACATTGCCTTTGAATGTTAATTTTTTGGTACAAAAA TAAATTTATATGAAAACCTGC AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC |
Restriction Sites | SgfI-RsrII |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_003701.4 |
Synonyms | CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE |
Summary | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] |
Locus ID | 8600 |
MW | 43.1 |
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