MMP2 (NM_001127891) Human 3' UTR Clone

Specifications

Product Data
Product Name	MMP2 (NM_001127891) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
ACCN	NM_001127891
Insert Size	1279 bp
Sequence Data	Insert Sequence (showhide) >SC213497 3’UTR clone of NM_001127891 The sequence shown below is from the reference sequence of NM_001127891. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGCATCAAATCCGACTGGCTAGGCTGCTGAGCTGGCCCTGGCTCCCACAGGCCCTTCCTCTCCACTGCC TTCGATACACCGGGCCTGGAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAGCCGTGCCTTCAGCTCTA CAGCTAATCAGCATTCTCACTCCTACCTGGTAATTTAAGATTCCAGAGAGTGGCTCCTCCCGGTGCCCA AGAATAGATGCTGACTGTACTCCTCCCAGGCGCCCCTTCCCCCTCCAATCCCACCAACCCTCAGAGCCA CCCCTAAAGAGATACTTTGATATTTTCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGCTGCCACACTTC AGGCTCTTCTCCTTTCACAACCTTCTGTGGCTCACAGAACCCTTGGAGCCAATGGAGACTGTCTCAAGA GGGCACTGGTGGCCCGACAGCCTGGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCCACTCCAGAC CCCTGGCTTTTCACTGCTGGCTGCCTTAGAACCTTTCTTACATTAGCAGTTTGCTTTGTATGCACTTTG TTTTTTTCTTTGGGTCTTGTTTTTTTTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGACTCAGGTT GTCTGAAGTCACTGCACAGTGCATCTCAGCCCACATAGTGATGGTTCCCCTGTTCACTCTACTTAGCAT GTCCCTACCGAGTCTCTTCTCCACTGGATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAGCCCTCCCT GCCCCTCCCTTCAACCATTCCCCATGGGAAATGTCAACAAGTATGAATAAAGACACCTACTGAGTGGCC GTGTTTGCCATCTGTTTTAGCAGAGCCTAGACAAGGGCCACAGACCCAGCCAGAAGCGGAAACTTAAAA AGTCCGAATCTCTGCTCCCTGCAGGGCACAGGTGATGGTGTCTGCTGGAAAGGTCAGAGCTTCCAAAGT AAACAGCAAGAGAACCTCAGGGAGAGTAAGCTCTAGTCCCTCTGTCCTGTAGAAAGAGCCCTGAAGAAT CAGCAATTTTGTTGCTTTATTGTGGCATCTGTTCGAGGTTTGCTTCCTCTTTAAGTCTGTTTCTTCATT AGCAATCATATCAGTTTTAATGCTACTACTAACAATGAACAGTAACAATAATATCCCCCTCAATTAATA GAGTGCTTTCTATGTGCAAGGCACTTTTCACGTGTCACCTATTTTAACCTTTCCAACCACATAAATAAA AAAGGCCATTATTAGTTGAATCTTATTGATGAAGAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001127891.3
Synonyms	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
Summary	This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Locus ID	4313
MW	47.9

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