JAK2 (NM_004972) Human 3' UTR Clone

Specifications

Product Data
Product Name	JAK2 (NM_004972) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	JTK10
ACCN	NM_004972
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC214337 3’UTR clone of NM_004972 The sequence shown below is from the reference sequence of NM_004972. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATCAAATAAGGGATAACATGGCTGGATGAAAGAAATGACCTTCATTCTGAGACCAAAGTAGATTTACA GAACAAAGTTTTATATTTCACATTGCTGTGGACTATTATTACATATATCATTATTATATAAATCATGAT GCTAGCCAGCAAAGATGTGAAAATATCTGCTCAAAACTTTCAAAGTTTAGTAAGTTTTTCTTCATGAGG CCACCAGTAAAAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTCA GTTAACATCACTCTTGTCTGGCAAAAGAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGAGACCTGAA AAAATTATTATGTAAATTTTGCAATGTTAAAGATGCACAGAATATGTATGTATAGTTTTTACCACAGTG GATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACACATGAGGGCTGGTGTTCATTAATACTGTT TTCTAATTTTTCCATAGTTAATCTATAATTAATTACTTCACTATACAAACAAATTAAGATGTTCAGATA ATTGAATAAGTACCTTTGTGTCCTTGTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTT TTAGCTTGTAGTTCCATGTACTGTAAATATTTTTCACATAAAGGGAACAAATGTCTAGTTTTATTTGTA TAGGAAATTTCCCTGACCCTAAATAATACATTTTGAAATGAAACAAGCTTACAAAGATATAATCTATTT TATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTATCTCCAAATTTTTC TAAGACTACTATGAACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGCCAGGAATATTGTCATCCTTT GAGCTGCTGACTGCCAATAACATTCTTCGATCTCTGGGATTTATGCTCATGAACTAAATTTAAGCTTAA GCCATAAAATAGATTAGATTGTTTTTTAAAAATGGATAGCTCATTAAGAAGTGCAGCAGGTTAAGAATT TTTTCCTAAAGACTGTATATTTGAGGGGTTTCAGAATTTTGCATTGCAGTCATAGAAGAGATTTATTTC CTTTTTAGAGGGGAAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGT AGAAAATTCATAACGTGTATCTTTAAGAAAAATGAGCATACATCTTAAATCTTTTCAATTAAGTATAAG GGGTTGTTCGTTGTTGTCATTTGTTATAGTGCTACTCCACTTTAGACACCATAGCTAAAATAAAATATG GTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTATTTATACAAAACTTAAAA TACTTGCTGTTTTGATTAAAAAGAAAATAGTTTCTTACTTTATTTTTACTGGTATGTTCTACTTTTTTG AAAGTTGTACTGAAGACTTCTGATTTTGGGTTGAAGGGAAGGAAAAGGAAGAAATGTTTTTTACATTCA TTATTATACTTAAAGCATTTTTAAAGCATTTTAATAGTTCTGGATGCAGAAATCATCTAAAATGACAGT GAATTAGGTTTTAAAAAGATTTTAGATTTTTTTGAAAGTTTAATTTTTATTTGTAAAGACTCCTCAAGG ATTTGTATATGCAACACAGTAAGGAGATCTTCCATTTTACTACCTTTCAAGTGAAAAATAGCCTATCAT ACAATATGCTTGATTTCAGATTTTCATACTAAAACTTAACTACATACTTAAAAGTAGGTTCTTATCAAG GGTCTCTAACATTGCTTTTTAAAACAAGATGTGAACTAACTTTTCTTAAACATTTTTTTAAATGCTTCA TCTTTTAGTTTTATATAAAGAATCCCACATGTACATTCTTGTTTTTAGAATGGGGTGACTACCTTATTA TAAAATTCCAAGTTTCCAAGAGACTTCTTTTCATTGAGGCTTCGTAAAGTTTTCCATTTTGATTCTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004972.4
Synonyms	JTK10
Summary	This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]
Locus ID	3717
MW	77.9

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