VGCNL1 (NALCN) (NM_052867) Human 3' UTR Clone

Specifications

Product Data
Product Name	VGCNL1 (NALCN) (NM_052867) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	bA430M15.1; CanIon; CLIFAHDD; IHPRF; IHPRF1; INNFD; VGCNL1
ACCN	NM_052867
Insert Size	1549 bp
Sequence Data	Insert Sequence (showhide) >SC215043 3’UTR clone of NM_052867 The sequence shown below is from the reference sequence of NM_052867. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAAAGTGGGGATGACCTTCTGGATATTTAGGTGGATGTCAATGTAGATGAATTTCTAGTGGTGGAAACC GTTTTCTAATAATGTCCTTGATTGTCCAGTGAGCAATCTGTAATTGATCTATAACTGAATTCCAGCTTG TCACAAGATGTTTATAAATTGATTTTCATCCTGCCACAGAAAGGCATAAGCTGCATGTATGATGGGTTA CTATCAATCATTGCTCAAAAAAATTTTTGTATAATGACAGTACTGATAATATTAGAAATGATACCGCAA GCAAATGTATATCACTTAAAAATGTCATATATTCTGTCTGCGTAAACTAAGGTATATATTCATATGTGC TCTAATGCAGTATTATCACCGCCCCGCAAAAGAGTGCTAAGCCCAAAGTGGCTGATATTTAGGGTACAG GGGTTATAGCTTTAGTTCACATCTTTCCCATTTCCACTAGAAATATTTCTCTTGAGAGAATTTATTATT TATGATTGATCTGAAAAGGTCAGCACTGAACTTATGCTAAAATGATAGTAGTTTTACAAACTACAGATT CTGAATTTTAAAAAGTATCTTCTTTTTCTCGTGTTATATTTTTAAATATACACAAGACATTTGGTGACC AGAACAAGTTGATTTCTGTCCTCAGTTATGTTAATGAAACTGTTGCCTCCTTCTAAGAAAATTGTGTGT GCAAGCACCAGGCAAAGAAATGGACTCAGGATGCTTAGCGGTTTAAAACAAACCTGTAGATAAATCACT TGAGTGACATAGTTGCGCAAAGATGTTAAGTTTCTTAAGAAACCTTTTAATAACTGAGTTTAGCAAAAA GAATAAAACTATATAGCTCAATTTATTTAAAAAAATCTTTGCATGTGTGATGTTATCATTGGCTTCATT TCTTACCCAAGGTATGTCTGTTTTGCCATAAATCAGCAGAGTCATTTCATTCTGGGTGATCCTAACACA CCATTGCTACGTTAGATTTGAAATGACATCTCTGTTAAAAGAATCTTCTATGGAAATAATGGTGCCCTG CAAAATCTTCCTTTGAACTCACAGGTTAGGGATCACACAACTTACTTAATCGTTTTTTGTTTTTGTTTT TTTTCCTTATATGTCAATGGCCCATGTCCTCCGGGAAAATTAGAAAAGCAAAATGATTACAAAGTGCTG TTAGATTTCTTGTGCTGGGCCAGCCAAGTAGAAGTGGACTTGACTTGGACCTTTAACTATTTTATTACA GATTGGACATTTGCTGTTCAGATGTTTTTTAACAGAGGGATTATCTCAGAATCCTGTGACCTCCAGGTT GTTTTATAATCTATTTTTCTCTATTTAACATTCCTCAGATAGATAGGCAAATAGGACATTCCTTCTGTG TCACAGAAGTATCGTGGTAGTGGCAGTCTACAGTTTATATGATTCATTGTAACTATGAGATAAAGAACA ACCAGTCATGTGGCCAAAAGGATTAGATTTGATTTGATGTTCACTTGGAGTTTACTTTTTGTACATACA AGATAAAATAAATATTGGATTTGTAAAATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_052867.4
Synonyms	bA430M15.1; CanIon; CLIFAHDD; IHPRF; IHPRF1; INNFD; VGCNL1
Summary	This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
Locus ID	259232
MW	60.2

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