IFIT2 (NM_001547) Human 3' UTR Clone

Specifications

Product Data
Product Name	IFIT2 (NM_001547) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; P54
ACCN	NM_001547
Insert Size	1926 bp
Sequence Data	Insert Sequence (showhide) >SC216990 3’UTR clone of NM_001547 The sequence shown below is from the reference sequence of NM_001547. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTTCAGCATCAAGCTGGAATGGGGAATGAAGAATAGAGATGTGGTGCCCACTAGGCTACTGCTGAAAG GGAGCTGAAATTCCTCCACCAAGTTGGTATTCAAAATATGTAATGACTGGTATGGCAAAAGATTGGACT AAGACACTGGCCATACCACTGGACAGGGTTATGTTAACACCTGAATTGCTGGGTCTTGAGAGAGCCCAA GGAGTTCTGGGAGAGGGACCAGATTGGGGGGTAGGTCCACGGGCTTGGTGATAGAATTATTTCTCGATT GACTTCTTGAGTGCAATTTGAACTGTAACATTTGCTTAGTCACCTTTAGTGGAGTAATCTACTGGGCTT GTTTCTATATTTATATAAAGCAGCCAAATCCTTCATGTAATATTGAAGTCCATTTTTGCAATGTTGTTC CATACTTGGAGTCATTTTGCATCCCATAGAGGTTAGTCCTGCATAGCCAGTAATGTGCTAAGTTCATCC AAAAGCTGGCGGACCAAAGTCTAAATAGGGCTCAGTATCCCCCATCGCTTATCTCTGCCTCCTTCCTCC TCCTTCCCAGTCTATCATCAACCTTGAGTATTCTACACAATGTGAATTCAAGTGCCTGATTAATTGAGG TGGCAACATAGTTTGAGACGAGGGCAGAGAACAGGAAGATACATAGCTAGAAGCGACGGGTACAAAAAG CAATGTGTACAAGAAGACTTTCAGCAAGTATACAGAGAGTTCACCTCTACTCTGCCCTCCTCATAGTCA TAATGTAGCAAGTAAAGAATGAGAATGGATTCTGTACAATACACTAGAAACCAACATAATGTATTTCTT TAAAACCTGTGTGAAAAAATAAATGTTCCACCAGTAGGGATAGGGGAAAAGTAACCAAAAGAGAGAAAG AGAAAGGAATGCTGGTTTATCTTTGTAGATTGTAATCGAATGGAGAAATTTGCAGTATTTTAGCCACTA TTAGGAATTTTTTTTTTTTGTAAAATGAAGACTGAACTCTGTTCAAATGCTTTCATGAACCTGGTTTGA GACGGTAGGAAAGCAACAAAACGTGGGAACCTGGTGACTAAGGGCCTGGTGCAAGGACTTGGGAAATGT CATTGATAATAGATGGTGGGGTTTTCCCCCCTTTAGAAATGTTGGATATTAAGTGATATAAACACTTCT TTTAACTCCGAAAATCTTCTGAGAAATCACAAAATTCACGGTATGCTTGGAACGATTGAGATTTTCTAG GTAGATGCTGAATAGCCTAGACATCAAAGTTGGTGTGAACCAAAATAGAGTCAGCTGACCCAGCATCAG CCACACTCTGGGTTGGAAAATGTTTGCCTGTTGGAATTAATTTAAGCTTAAGTATATATCAACATTATT TTATTGTGCAATTAAAACAATACAAATTCATGGTTTTTTAAAGTTAAAAATTCTAACCACTGTAACAAC AGTTTTTGTGTTATTTTCTGTATTAAACATCTTGTTGCACGCATTTGAGGTCATCAGGGTGCAAAATTT GTATTCCTGAAAATGTCATATATTTTCATTAATAAATAACCTAAATATGATAAAACATAAAGCAGTGTT CTGGTTCATCTGGAATTTTGCTGTACTTTAAATCTTTCAGACTCAGCTACTGATAAATGAAACGTTACA CAGGTGTGAACCAAATCCAAATAACCTCGACTGGTCTACTATCATAATCACCTGAACAGAACAAAACTT TTTCCTCAGCTTTAAGAGTCCAGGGCTTCGGATAACAGCTGCCATCTGCCACCTGCTACCATTGACCTA CGTGAACACAGACATTCTGTCTCCACCTTGATGGTGGGTGGGCTGCTCCCCTTTTCTTTGTTAAATTTT GTGCTTTCATCACATTTTCTCTATTCTGACCTCTGTTATGAGAAATAAAAGTCACTGATTCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001547.5
Synonyms	cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; P54
Summary	IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.[UniProtKB/Swiss-Prot Function]
Locus ID	3433
MW	73.4

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