FZR1 (NM_016263) Human 3' UTR Clone

CAT#: SC217036

3' UTR clone of fizzy/cell division cycle 20 related 1 (Drosophila) (FZR1) transcript variant 2 for miRNA target validation



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CNY 5,795.00


货期*
3周

规格
    • 10 ug

Product images

经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name FZR1 (NM_016263) Human 3' UTR Clone
Vector pMirTarget
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
ACCN NM_016263
Insert Size 2000 bp
Sequence Data
>SC217036 3’UTR clone of NM_016263
The sequence shown below is from the reference sequence of NM_016263. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
GTGCTCAACCTCTTCACCAGGATCCGGTAAACCTGCCGGGCAGGACCGTGCCACACCAGCTGTCCAGAG
TCGGAGGACCCCAGCTCCTCAGCTTGCATGGACTCTGCCTTCCCAGCGCTTGTCCCCCGAGGAAGGCGG
CTGGGCGGGCGGGGAGCTGGGCCTGGAGGATCCTGGAGTCTCATTAAATGCCTGATTGTGAACCATGTC
CACCAGTATCTGGGGTGGGCACGTGGTCGGGGACCCTCAGCAGCAGGGGCTCTGTCTCCCTTCCCAAAG
GGCGAGAACCACATTGGACGGTCCCGGCTCAGACCGTCTGTACTCAGAGCGACGGATGCCCCCTGGGAC
CCTCACTGCCTCCGTCTGTTCATCACCTGCCCACCGGAGCCGCATGCTCTTCCTGGAACTGCCCACGTC
TGCACAGAACAGACCACCAGACGCCAGGGCTGATTGGTGGGGGCCTGAGACCCCGGTTGCCCATTCATG
GCTGCACCCCACCATGTCAAACCCAAGACCAGCCCCAAGGCCAGACCAAGGCATGTAGGCCTGGGCAGG
TGGCTCGGGGCCACTGGCGGAGCCAGCCTGTGGATCCAAGAGACAGTCCCCACCTGGGCTTCACGGCAT
CCTTGCAGCCACCTCTGCTGTCACTGCTCGAAGCAGCAGTCTCTCTGGAAGCATCTGTGTCATGGCCAT
CGCCCGGCGGTCAGTGGGCTTCAGATGGGCCTGTGCATCCTGGCCAAGCGTCACCCTCACACTGGAGGA
GGATGTCTGCTCTGGACTTATCACCCCAGGAGAACTGAACCCGGACCTGCTCACTGCCCTGGCTGGAGA
GGAGCACAACAGATGCCACGTCTTCGTGCATTCGCCAACACGTGCCCTCACAGGGCCAGCGTCCTCCTT
CCCTGCGCAAGACTTGCGTCCCCCATGCCTGCTGGGTGGCTGGGTCCTGTGGAGGCCAGCAGCGGTGTG
GCCCCCGCCCCCAGGCTGCCTGTGTCTTCACCTGTCCTGTCCACCAGCGCCAACAGCCGTGGGGAAGCC
AAGGAGACCCAAGGGGTCCAGGAGGTGGGCGCCCTCCATCCTTCGAGAAGCTTCCCAGGCTCCTCTGCT
TCTCTGTCTCATGCTCCCAGGCTGCACAGCAGGCAGGGAGGGAGGCAAGGCAGGGGAGTGGGGCCTGAG
CTGAGCACTGCCCCCTCACCCCCCCACCACCCCTTCCCATTTCATCGGTGGGGACGTGGAGAGGGTGGG
GCGGGCTGGGGTTGGAGGGTCCCACCCACCACCCTGCTGTGCTTGGGAACCCCCACTCCCCACTCCCCA
CATCCCAACATCCTGGTGTCTGTCCCCAGTGGGGTTGGCGTGCATGTGTACATATGTATTTGTGACTTT
TCTTTGGATTTGTTTTGTGTTTTTGTTGACTAGTCCTGGAAATGTTTGAGGCTAGACGGGGAGGGGCCA
GGACCCACCCACTGCTCCTGGGGGATGAGGTCCTGGTTTTAAAGCCCCGTCATTTCAAGCGGGTCGATC
TTCCACATTCACTGGAGAGACTCTCCCCACCTCTGTCTGGGTGGGGCGCGGACCCCTCACTGTGCGCCT
GTGCAGGGGGTGCTGGTGCACGTGGCAGTGTGGATTTCCAGTGGTCACGGTCTTACTGTTTCAAGGTTT
TTAAATAAGAAAACCAACCCTGCCTTCGCCCATGCCCGCCCCTGCCCGCAGTTGCCAAAGAGCCGCCTT
GTCGCTGTGGGCGTCAGGGCTTGGCTGGCTCAGTGCACAACCCACAGTGGCCTTCAGAGGCTCCTCCTG
GGACTGGGAACCGCCGCAGGGCCAGGCGGACGGCGTGAGGTTTGTGTTGGGGCTGGTTCTGCCCATGCT
AGGGGGTGGGGGAGCTCCCAGGACAGACCAGCCTTGTTTCTCATGTAATGCAGTGACGCTGTCATTAAA
CACGTGGATTCATGTGTGGCCGGGACTGGCTGGCTCTAGGTCCCCGGCTCGGGTGGGGTCACACGGTC
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_016263.4
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Summary Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).[UniProtKB/Swiss-Prot Function]
Locus ID 51343
MW 71
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