Hamartin (TSC1) (NM_000368) Human 3' UTR Clone
CAT#: SC222100
3' UTR clone of tuberous sclerosis 1 (TSC1) transcript variant 1 for miRNA target validation
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CNY 19,570.00
货期*
3周
规格
Cited in 1 publication. |
Product images
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经常一起买 (2)
Specifications
Product Data | |
Product Name | Hamartin (TSC1) (NM_000368) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | LAM; TSC |
ACCN | NM_000368 |
Insert Size | 2000 bp |
Sequence Data |
>SC222100 3’UTR clone of NM_000368
The sequence shown below is from the reference sequence of NM_000368. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACAATGAGACTCATCATGAACACAGCTAAGGAATGATGGTCAATCAGTGTTAACTTGCATATTGTTGG CACAGAACAGGAGGTGTGAATGCACGTTTCAAAGCTTTCCTGTTTCCAGGGTCTGAGTGCAAGTTCATG TGTGGAAATGGGACGGAGGTCCTTTGGACAGCTGACTGAATGCAGAACGGTTTTTGGATCTGGCATTGA AATGCCTCTTGACCTTCCCCTCCACCCGCCCTAACCCCCTCTCATTTACCTCGCAGTGTGTTCTAATCC AAGGGCCAGTTGGTGTTCCTCAGTAGCTTTACTTTCTTCCTTTCCCCCCCAAATGGTTGCGTCCTTTGA ACCTGTGCAATATGAGGCCAAATTTAATCTTTGAGTCTAACACACCACTTTCTGCTTTCCCGAAGTTCA GATAACTGGGTTGGCTCTCAATTAGACCAGGTAGTTTGTTGCATTGCAGGTAAGTCTGGTTTTGTCCCT TCCAGGAGGACATAGCCTGCAAAGCTGGTTGTCTTTACATGAAAGCGTTTACATGAGACTTTCCGACTG CTTTTTTGATTCTGAAGTTCAGCATCTAAAGCAGCAGGTCTAGAAGAACAACGGTTTATTCATACTTGC ATTCTTTTGGCAGTTCTGATAAGCTTCCTAGAAAGTTCTGTGTAAACAGAAGCCTGTTTCAGAAATCTG GAGCTGGCACTGTGGAGACCACACACCCTTTGGGAAAGCTCTTGTCTCTTCTTCCCCCACTACCTCTTA TTTATTTGGTGTTTGCTTGAATGCTGGTACTATTGTGACCACAGGCTGGTGTGTAGGTGGTAAAACCTG TTCTCCATAGGAGGGAAGGAGCAGTCACTGGGAGAGGTTACCCGAGAAGCACTTGAGCATGAGGAACTG CACCTTTAGGCCATCTCAGCTTGCTGGGCCTTTTGTTAAACCCTTCTGTCTACTGGCCTCCCTTTGTGT GCATACGCCTCTTGTTCATGTCAGCTTATATGTGACACTGCAGCAGAAAGGCTCTGAAGGTCCAAAGAG TTTCTGCAAAGTGTATGTGACCATCATTTCCCAGGCCATTAGGGTTGCCTCACTGTAGCAGGTTCTAGG CTACCAGAAGAGGGGCAGCTTTTTCATACCAATTCCAACTTTCAGGGGCTGACTCTCCAGGGAGCTGAT GTCATCACACTCTCCATGTTAGTAATGGCAGAGCAGTCTAAACAGAGTCCGGGAGAATGCTGGCAAAGG CTGGCTGTGTATACCCACTAGGCTGCCCCACGTGCTCCCGAGAGATGACACTAGTCAGAAAATTGGCAG TGGCAGAGAATCCAAACTCAACAAGTGCTCCTGAAAGAAACGCTAGAAGCCTAAGAACTGTGGTCTGGT GTTCCAGCTGAGGCAGGGGGATTTGGTAGGAAGGAGCCAGTGAACTTGGCTTTCCTGTTTCTATCTTTC ATTAAAAAGAATAGAAGGATTCAGTCATAAAGAGGTAAAAAACTGTCACGGTACGAAATCTTAGTGCCC ACGGAGGCCTCGAGCAGAGAGAATGAAAGTCTTTTTTTTTTTTTTTTTTTTTTAGCATGGCAATAAATA TTCTAGCATCCCTAACTAAAGGGGACTAGACAGTTAGAGACTCTGTCACCCTAGCTATACCAGCAGAAA ACCTGTTCAGGCAGGCTTTCTGGGTGTGACTGATTCCCAGCCTGTGGCAGGGCGTGGTCCCAACTACTC AGCCTAGCACAGGCTGGCAGTTGGTACTGAATTGTCAGATGTGGAGTATTAGTGACACCACACATTTAA TTCAGCTTTGTCCAAAGGAAAGCTTAAAACCCAATACAGTCTAGTTTCCTGGTTCCGTTTTAGAAAAGG AAAACGTGAACAAACTTAGAAAGGGAAGGAAATCCCATCAGTGAATCCTGAAACTGGTTTTAAGTGCTT TCCTTCTCCTCATGCCCAAGAGATCTGTGCCATAGAACAAGATACCAGGCACTTAAAGCCTTTTCCTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_000368.5 |
Synonyms | LAM; TSC |
Summary | This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018] |
Locus ID | 7248 |
MW | 75.7 |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs
,Dombkowski, AA;Batista, CE;Cukovic, D;Carruthers, NJ;Ranganathan, R;Shukla, U;Stemmer, PM;Chugani, HT;Chugani, DC;,
Cereb. Cortex
,PubMed ID 25452577
[TSC1]
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