Helb (NM_080446) Mouse Untagged Clone
CAT#: MC203460
Helb (untagged) - Mouse helicase (DNA) B (Helb), (10ug)
CNY 7,488.00
Product images
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | AI447783; D10Ertd664e |
Vector | PCMV6-Kan/Neo |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>BC068140
GTTGTTTTGAGCCAAGTTCGCCGAAGAGATAATGGCTAGGCAGGATCGTCTGCGCGAGCTCCTGGGCCCT CTGCACCCGTACAAGAGCGACGACGAGGAGGAGGATTGTGCGCAGGAGGAGGAGGGGGAGCAGGAGGAGG AGTTTGTGGATGCCGAGGAACTCTGCAGCGGGGGCATCAAGGCGGGCAGCCTCCCTGGGCGCGCGCGAGT GTCTATCCCTGATGAGTATACTAAAGAGAAATGTACCGTGTACGGACGTTTCCCACTCAAAGGTCCGTGG TGGCGCGTGAAGGTCCAGGTCCTGAAACCCCAGCGATCCAGGAGCTATCAAGTTCAAGGCTTTCCGGCAT ACTTTCTACAGGTTGATATGTCGCCACCAGATCAAAAACAAATCTGTTCGCTTTTTCTTAAAGAATGCAA CTTAGCCTCTGAGCGCATACAGGAATTTTTAAAATGGGTAGAAAAAGTGTCAAGCTTTGAAAATCTACAC TTTGAAAATCTTTGGGAAACATTAAGGCTTTTCTACAGAGAAACCGAAAAGAAAGATAAAAAGCTGTCTA CACCAAGGGAGCAGCAGGGTGAGGAGATGAGAGTGGAAAAATCATTCGCATTTATAAGTGCAATGGTAGC TCTGCAATTCCCCAAAGTCATGGAATTCCTTCCATCGCTTTTCCCTCGACACTTCAAAAGGCTCATCAGC TCGAGTTCTGATTGGGTGCTGGGATGCATAGAAGATGTTCTGGGTACACAGCCGTGGAAGCTGGGCTTCA GGAGGATAACCTACAGAGAAATGAAACTAGTGCGCTGTGAGGCCAGCTGGACAGCGTTCAGTCAGTGCCC CTCGCTGCTCCAGCTGATGACGCCCCTGCAGAAGAATGCATTGGTCATATATTCTAAGCTGAGGCAGACA TGCAGAGAAGACGGACACACGTACATTGAAGTAAAAGACTTGACCTCGGGCTTGTCGGAGCATATGTCAT TCGAGGAAGCGTGTCAGTCTCTGGCGTTTCTGAAGGACATTGACGTGGTCATTTATGAGAAGGACTATGT CTTTCTTTCTGAACTGTACGAGGCCGAGCAAGACATCGCCTCCTCCATCTGCGAGCTGATGAGCAGACCT CCGTGGCACTTAAAAGTGGACGTGAAGAACGTCCTGGCGTCAATTAGAGGCGCAAAGCCCAACGATCCAG GAAGTGCTGAGGCAGTGGAAGGGAGCAAGCCGGAGGAGGTGGGGTCAGAGCAGGGTGACAGTGTTTTAGA CGCCCAAGATGGCGATGACCATGTTAGAAGCAATGGCGAACACGTCGCAAATGCAGAAATAAACGACGTC CCACTGGATCAAGATCAGGTGGTCGCCCTGGAGACGATCTGCGCCAACGCGGTGACTGTCCTCAGTGGGA AAGGCGGCTGTGGGAAGACCACCATTGTTAGCCGTCTTTTTAAGCACATGGAACATCTGGAAGAAACGGA AGTGCAGCAAGCCTGCGAGGATTTTGAACAAGACCAGGAAGCCTCAGAAGAGTGGCTTGACTGTCCTAAG CAGAGCCCAGCCGGTGTGGACAAGGCTGTAGAAGTCTTGCTCACCGCACCTACAGGGAAGGCTGCTGGCT TATTGAGGCAGAGGACCGATCTTCCGGCTTACACGCTGTGCCAGGTCAATTACAGCTTCTATATGTGGAA AACGAAAAATGAGGTGGACAAGCCGTGGAAATTCTCCACGGTTCGAGTTCTGGTTGTGGACGAAGGGAGT TTGGTGTCTGTAGGGATCTTCAAGTCAGTGTTACAGTTGCTGTGCAAACACTCCAAGCTGTCCAAGCTCA TCATCCTTGGTGATGTTAGACAGTTGCCCAGTATTGAACCTGGTAACATGCTGCAGGATGTCTTTGAGAC TCTTAAGTCAAGACAGTGTGCCATCGAACTAAAGACGAACCACAGGACAGAGTCTCAGCTGATTGTGGAC AATGCTACAAGAATCTCCAGACGTCAGTTTCCAAAATTTGATGCTGAACTAAATATCTGTGGTAATCCTA CATTACCTCTCTCCATTCAAGATAAGACATTTATCTTTGTGAGACTCCCTGAAGAAGACAGCAGATCTCA GTCGTCTAAAGGTGAACACCGATCTAATTTATATACTGCAGTTAAAACTTTGCTTCAAGGAAAGGACTTC TGCTCTTTTGAAAGTTCAAAAACATCGCAATTTATTGCATTTAGAAGGCAAGACTGTGACCTCATCAATG ACTGCTGCTGCAAGCATTACACAGGCCACCTCATCAAAGACCATGAGAAGAAACTCATCTTTGCCGTCGG TGATAAGATCTGCTGTACCCGGAATGCATACCTCTCAGATTTACTCCCCGACAAAGACCAGGAAGCCGAG GGGAAAGGCTATGGAGACGCCCCTGACGACGATGCTAAAATCAAACAGGATTTCGAAAGCAGCATCCGCC TGTGCAACGGGGAAATATTTTTCATAACACGGGATGTAACTGACGTAACTTTCAAAAGAAAAAGACTTCT GACCATTAATAACGAGGCCGGTTTGGAAGTGACTGTGGACTTTAGCAAACTAATGGCAAACTGTCAGATC AAGCATGCCTGGGCAAGGACCATTCATACTTTTCAGGGGTCCGAGGAGAACACAGTCGTCTACGTCGTGG GGAAGGCAGGCCGCCAGCACTGGCAACATGTTTACACGGCAGTGACCCGGGGCCGCTCCAGAGTGTACAT CATCGCGCAGGAGTCTGAACTCAGGAGTGCCACCCGGAAGCGCGGTTTCCCCAGGCAGACGCGTTTGAAA CACTTCTTGCAGAAGAAGCTCTCTGGCAGCTGCGCACCCTCAACAGGTTTCGCATCCCAGCCTTCGAGCC CTCGAGTCGGAGGAAGACCTGACACCCAGCCTCCAGCGTCACACCTCTGTAGAACCCCAGACAACAAAGC CACTGCAGACAGCGCCAGAGGCGACGAAAGATGGCTGTCAGCTTCTGTTAACGATGACGTGGATACGGAT GAGGAGTCAGCACAGCTCAGAGGGTCCAAAAGAATCGGTGACGGCTTCCCGTTTGATGAAGAAAGCCCCA GTAAATTCCGTATGGTTGAAGCGCCATCTCCACAGGTGTCCTCTGTGTTTCAGAATATGAGGTTGAATAC TCTCACTCCCAGACAGCTTTTTAAACCCACCGACAATCAAGACACAGGTACGGCAGGTGTGGCGGACGAC GCCAACGATCCCAGCAATCAGGAGATGGAAATGTGAGGATCTGCGTTCATGGCCAGCCTGGGCAACATCG TAAGACCCTGCTCAGCCCATACCACCACCACCACCACCACCACTGAAAACCTCAAAGCAGAAAAAAAAAA GTTTACTTCATATTAATCAAGAAATTATTATTTTTTTCCTCCCAAGACAAGATGAACATTTTAGCTTCAA AGTTTCAAACTTCAAACTCTGAGAAGACAGCATTATGGTTTTGGGCATTTGTAATTTTGGGCACATGACC CAAAATAAAATTTTTATATTATTTTTAAATCTAAGTTTCAAAAGGAGGTATTCTAAAATCACCCAATCCA AGAAAACCATGATGATTTCAGCCTCTGTCCTCGTGAGAACAGTTGACAGGGGACACAGTTAGGGGAAAAG GTGCTGTATGCTTAAAACACTCCCGTTTTAGGGGCTGCTGGATGTTTTGTGATAATGCCATGTGATCATT GCGGATCTCCTTTGCCAGCACACTGAACCAGCAAAGGTGGACTGATTGTACCTGTTGATTGTAACACATT CAAGGATGCTGTTTGTGGCGACATCCTTGCTGTGATGCTGTGGCCATCACTCCATTCCTGTGCCTGGGGC TCTGCGTACGTGGGGCTTGGATATGCCTTTCTGAGTTGGGAGTAAGTTTAGCATATATCCCATTGTAGGG AAGACTTTCTCTTAAAGCATATTGGTTTTTAAATATTTATTACCTAGTGGTACTGTGGCTTGATCGTGTC TTCCCAAACCTGTGTGAGTTTTTTTTTGGGGGGGTGGGGGTGGGGGGTGGTTTCGAGACAGGGTTTCTCT GTACAGCCCTGGGGCTGACCTGGAACTCACTTTGTAGACCAGGCTGGCCTCAAACTCAGAAATCCGCCTG CCTCTGCCTCCCGAGTGCTGGGATTAAAGGCGTGCGCCACCACTGCCTGGCATGGCAGAGTGGTAGAGAG AGTTTTTCCATCTTTCTCCCTTCTTTTGGTGCTGGAACTGAAGCCAAGGTCTCATTCCTTCTAAGAAAGC ACTTTACTGCTTAATTTTATTCCTGATCCTAAACATAACTTTTATATGTACCAGGAAGTAAACAAACAAG ACCAGTCATGTGATGCAGCTGATGGTAATGCTTTTGTTATTTCGGGTGCCCTGGGACTGATCTGCAGCAT TTCTGAGATAGACCTTTGTGAGAAATAAATCCACTATTCTTTTAAAAAAAAAAAAAAAAAAAA |
Restriction Sites | AscI-NotI |
ACCN | NM_080446 |
Insert Size | 3225 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | BC068140, AAH68140 |
RefSeq Size | 4473 bp |
RefSeq ORF | 3225 bp |
Locus ID | 117599 |
UniProt ID | Q6NVF4 |
Gene Summary | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress (PubMed:11557815, PubMed:7596831, PubMed:7794903).[UniProtKB/Swiss-Prot Function] |
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SDS |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG211593 | Helb (tGFP-tagged) - Mouse helicase (DNA) B (Helb) |
CNY 10,360.00 |
|
MR211593 | Helb (Myc-DDK-tagged) - Mouse helicase (DNA) B (Helb) |
CNY 7,480.00 |
|
MR211593L3 | Lenti ORF clone of Helb (Myc-DDK-tagged) - Mouse helicase (DNA) B (Helb) |
CNY 11,310.00 |
|
MR211593L4 | Lenti ORF clone of Helb (mGFP-tagged) - Mouse helicase (DNA) B (Helb) |
CNY 11,310.00 |