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Lrp5 (NM_008513) Mouse Untagged Clone
CAT＃: MC203730
Lrp5 (untagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5), (10ug)
CNY 11,048.00
货期*
现货
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC203730 representing NM_008513.
Blue=ORF Red=Cloning site Green=Tag(s) CTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCG CGCCAGATCTCAAGCTTAACTAGCTAGCGGACCGAC ATGGAAACGGCGCCGACCCGGGCCCCTCCGCCGCCGCCGCCGCCGCTGCTGCTGCTGGTGCTGTACTGC AGCTTGGTCCCCGCCGCGGCCTCACCGCTCCTGTTGTTTGCCAACCGCCGGGATGTGCGGCTAGTGGAT GCCGGCGGAGTGAAGCTGGAGTCCACCATTGTGGCCAGTGGCCTGGAGGATGCAGCTGCTGTAGACTTC CAGTTCTCCAAGGGTGCTGTGTACTGGACAGATGTGAGCGAGGAGGCCATCAAACAGACCTACCTGAAC CAGACTGGAGCTGCTGCACAGAACATTGTCATCTCGGGCCTCGTGTCACCTGATGGCCTGGCCTGTGAC TGGGTTGGCAAGAAGCTGTACTGGACGGACTCCGAGACCAACCGCATTGAGGTTGCCAACCTCAATGGG ACGTCCCGTAAGGTTCTCTTCTGGCAGGACCTGGACCAGCCAAGGGCCATTGCCCTGGATCCTGCACAT GGGTACATGTACTGGACTGACTGGGGGGAAGCACCCCGGATCGAGCGGGCAGGGATGGATGGCAGTACC CGGAAGATCATTGTAGACTCCGACATTTACTGGCCCAATGGGCTGACCATCGACCTGGAGGAACAGAAG CTGTACTGGGCCGATGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCCTTCCGGCAGAAG GTGGTGGAGGGCAGCCTCACTCACCCTTTTGCCCTGACACTCTCTGGGGACACACTCTACTGGACAGAC TGGCAGACCCGCTCCATCCACGCCTGCAACAAGTGGACAGGGGAGCAGAGGAAGGAGATCCTTAGTGCT CTGTACTCACCCATGGACATCCAAGTGCTGAGCCAGGAGCGGCAGCCTCCCTTCCACACACCATGCGAG GAGGACAACGGTGGCTGTTCCCACCTGTGCCTGCTGTCCCCGAGGGAGCCTTTCTACTCCTGTGCCTGC CCCACTGGTGTGCAGTTGCAGGACAATGGCAAGACGTGCAAGACAGGGGCTGAGGAAGTGCTGCTGCTG GCTCGGAGGACAGACCTGAGGAGGATCTCTCTGGACACCCCTGACTTCACAGACATAGTGCTGCAGGTG GGCGACATCCGGCATGCCATTGCCATTGACTACGATCCCCTGGAGGGCTACGTGTACTGGACCGACGAT GAGGTGCGGGCTATCCGCAGGGCGTACCTAGATGGCTCAGGTGCGCAGACACTTGTGAACACTGAGATC AATGACCCCGATGGCATTGCTGTGGACTGGGTCGCCCGGAACCTCTACTGGACAGATACAGGCACTGAC AGAATTGAGGTGACTCGCCTCAACGGCACCTCCCGAAAGATCCTGGTATCTGAGGACCTGGACGAACCG CGAGCCATTGTGTTGCACCCTGTGATGGGCCTCATGTACTGGACAGACTGGGGGGAGAACCCCAAAATC GAATGCGCCAACCTAGATGGGAGAGATCGGCATGTCCTGGTGAACACCTCCCTTGGGTGGCCCAACGGA CTGGCCCTGGACCTGCAGGAGGGCAAGCTGTACTGGGGGGATGCCAAAACTGATAAAATCGAGGTGATC AACATAGATGGGACAAAGCGGAAGACCCTGCTTGAGGACAAGCTCCCACATATTTTTGGGTTCACACTG CTGGGGGACTTCATCTACTGGACCGACTGGCAGAGACGCAGTATTGAAAGGGTCCACAAGGTCAAGGCC AGCCGGGATGTCATCATTGATCAACTCCCCGACCTGATGGGACTCAAAGCTGTGAATGTGGCCAAGGTT GTCGGAACCAACCCATGTGCGGATGGAAATGGAGGGTGCAGCCATCTGTGCTTCTTCACCCCACGTGCC ACCAAGTGTGGCTGCCCCATTGGCCTGGAGCTGTTGAGTGACATGAAGACCTGCATAATCCCCGAGGCC TTCCTGGTATTCACCAGCAGAGCCACCATCCACAGGATCTCCCTGGAGACTAACAACAACGATGTGGCT ATCCCACTCACGGGTGTCAAAGAGGCCTCTGCACTGGACTTTGATGTGTCCAACAATCACATCTACTGG ACTGATGTCAGCCTCAAGACGATCAGCCGAGCCTTCATGAATGGGAGCTCAGTGGAGCACGTGATTGAG TTTGGCCTCGACTACCCTGAAGGAATGGCTGTGGACTGGATGGGCAAGAACCTCTATTGGGCGGACACA GGGACCAACAGGATTGAGGTGGCCCGGCTGGATGGGCAGTTCCGGCAGGTGCTTGTGTGGAGAGACCTT GACAACCCCAGGTCTCTGGCTCTGGATCCTACTAAAGGCTACATCTACTGGACTGAGTGGGGTGGCAAG CCAAGGATTGTGCGGGCCTTCATGGATGGGACCAATTGTATGACACTGGTAGACAAGGTGGGCCGGGCC AACGACCTCACCATTGATTATGCCGACCAGCGACTGTACTGGACTGACCTGGACACCAACATGATTGAG TCTTCCAACATGCTGGGTCAGGAGCGCATGGTGATAGCTGACGATCTGCCCTACCCGTTTGGCCTGACT CAATATAGCGATTACATCTACTGGACTGACTGGAACCTGCATAGCATTGAACGGGCGGACAAGACCAGT GGGCGGAACCGCACCCTCATCCAGGGTCACCTGGACTTCGTCATGGACATCCTGGTGTTCCACTCCTCC CGTCAGGATGGCCTCAACGACTGCGTGCACAGCAATGGCCAGTGTGGGCAGCTGTGCCTCGCCATCCCC GGAGGCCACCGCTGTGGCTGTGCTTCACACTACACGCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCC TCCACCTTCTTGCTGTTCAGCCAGAAATTTGCCATCAGCCGGATGATCCCCGATGACCAGCTCAGCCCG GACCTTGTCCTACCCCTTCATGGGCTGAGGAACGTCAAAGCCATCAACTATGACCCGCTGGACAAGTTC ATCTACTGGGTGGACGGGCGCCAGAACATCAAGAGGGCCAAGGACGACGGTACCCAGCCCTCCATGCTG ACCTCTCCCAGCCAAAGCCTGAGCCCAGACAGACAGCCACACGACCTCAGCATTGACATCTACAGCCGG ACACTGTTCTGGACCTGTGAGGCCACCAACACTATCAATGTCCACCGGCTGGATGGGGATGCCATGGGA GTGGTGCTTCGAGGGGACCGTGACAAGCCAAGGGCCATTGCTGTCAATGCTGAGCGAGGGTACATGTAC TTTACCAACATGCAGGACCATGCTGCCAAGATCGAGCGAGCCTCCCTGGATGGCACAGAGCGGGAGGTC CTCTTCACCACAGGCCTCATCCGTCCCGTGGCCCTTGTGGTGGACAATGCTCTGGGCAAGCTCTTCTGG GTGGATGCCGACCTAAAGCGAATCGAAAGCTGTGACCTCTCTGGGGCCAACCGCCTGACCCTGGAAGAT GCCAACATCGTACAGCCAGTAGGTCTGACAGTGCTGGGCAGGCACCTCTACTGGATCGACCGCCAGCAG CAGATGATCGAGCGCGTGGAGAAGACCACTGGGGACAAGCGGACTAGGGTTCAGGGCCGTGTCACCCAC CTGACAGGCATCCATGCCGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCATCCTTGTGCCCGAGAC AATGGCGGCTGCTCCCACATCTGTATCGCCAAGGGTGATGGAACACCGCGCTGCTCGTGCCCTGTCCAC CTGGTGCTCCTGCAGAACCTGCTGACTTGTGGTGAGCCTCCTACCTGCTCCCCTGATCAGTTTGCATGT ACCACTGGTGAGATCGACTGCATCCCCGGAGCCTGGCGCTGTGACGGCTTCCCTGAGTGTGCTGACCAG AGTGATGAAGAAGGCTGCCCAGTGTGCTCCGCCTCTCAGTTCCCCTGCGCTCGAGGCCAGTGTGTGGAC CTGCGGTTACGCTGCGACGGTGAGGCCGACTGCCAGGATCGCTCTGATGAAGCTAACTGCGATGCTGTC TGTCTGCCCAATCAGTTCCGGTGCACCAGCGGCCAGTGTGTCCTCATCAAGCAACAGTGTGACTCCTTC CCCGACTGTGCTGATGGGTCTGATGAGCTCATGTGTGAAATCAACAAGCCACCCTCTGATGACATCCCA GCCCACAGCAGTGCCATTGGGCCCGTCATTGGTATCATCCTCTCCCTCTTCGTCATGGGCGGGGTCTAC TTTGTCTGCCAGCGTGTGATGTGCCAGCGCTACACAGGGGCCAGTGGGCCCTTTCCCCACGAGTATGTT GGTGGAGCCCCTCATGTGCCTCTCAACTTCATAGCCCCAGGTGGCTCACAGCACGGTCCCTTCCCAGGC ATCCCGTGCAGCAAGTCCGTGATGAGCTCCATGAGCCTGGTGGGGGGGCGCGGCAGTGTGCCCCTCTAT GACCGGAATCACGTCACTGGGGCCTCATCCAGCAGCTCGTCCAGCACAAAGGCCACACTATATCCGCCG ATCCTGAACCCACCCCCGTCCCCGGCCACAGACCCCTCTCTCTACAACGTGGACGTGTTTTATTCTTCA GGCATCCCGGCCACCGCTAGACCATACAGGCCCTACGTCATTCGAGGTATGGCACCCCCAACAACACCG TGCAGCACAGATGTGTGTGACAGTGACTACAGCACCAGTCGCTGGAAGAGCAGCAAATACTACCTGGAC TTGAATTCGGACTCAGACCCCTACCCCCCCCCGCCCACCCCCCACAGCCAGTACCTATCTGCAGAGGAC AGCTGCCCACCCTCACCAGGCACTGAGAGGAGTTACTGCCACCTCTTCCCGCCCCCACCGTCCCCCTGC ACGGACTCGTCCTGA ACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATTACAAG GATGACGACGATAAGGTTTAAACGGCCGGCCGCGGT |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_008513 |
| Insert Size | 4845 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC011374 |
| RefSeq Size | 5172 bp |
| RefSeq ORF | 4845 bp |
| Locus ID | 16973 |
| UniProt ID | Q91VN0 |
| MW | 178.9 kDa |
| Gene Summary | Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11956231). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (PubMed:15142971). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11956231). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (By similarity). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (By similarity). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (PubMed:11956231).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG212054 | Lrp5 (tGFP-tagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5) |
CNY 13,300.00 |
|
| MR212054 | Lrp5 (Myc-DDK-tagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5) |
CNY 11,040.00 |
|
| MR212054L3 | Lenti ORF clone of Lrp5 (Myc-DDK-tagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5) |
CNY 13,970.00 |
|
| MR212054L4 | Lenti ORF clone of Lrp5 (mGFP-tagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5) |
CNY 13,970.00 |
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