Abcd2 (BC019187) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	ALDR, ABC39, ALDL1, ALDRP
Vector	PCMV6-Kan/Neo
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >BC019187 CCACGCGTCCGTAAGAGTAAAGGAGACAAGCTGCAGAGCATGGGAGGCTGTGGGGTCTTCTGAAACCTTT GCTGGGCTTTCCGCGGAGCATGAGCTTTTAAAACGAATTCTTTTCAAAGAAACCCATTTGTGTAGCTGGA AAAATGATACACATGCTAAATGCAGCAGCCTATCGGGTGAAATGGACCAGATCCGGTGCTGCTAAAAGGG CTGCCTGCCTGGTGGCTGCGGCATATGCTCTGAAAACCCTCTATCCCATCATTGGCAAGCGTTTAAAGCA GCCTGGCCACAGGAAGGCAAAAGCAGAAGCTTACTCGCCTGCAGAGAACAGAGAAATACTGCATTGCACG GAGATCATCTGTAAAAAACCTGCGCCGGGACTAAATGCAGCTTTTTTCAAACAGCTACTAGAACTTCGGA AAATCCTCTTTCCAAAACTTGTGACCACTGAAACGGGGTGGCTCTGCCTCCACTCGGTGGCTCTAATCTC AAGAACATTTCTCTCTATTTATGTGGCTGGTCTGGATGGGAAAATCGTGAAAAGCATCGTGGAAAAGAAG CCTCGGACTTTCATCATCAAATTAATCAAGTGGCTTATGATTGCTATCCCTGCTACCTTTGTCAACAGTG CTATCAGGTACCTGGAATGCAAACTGGCATTGGCCTTTAGAACTCGCTTAGTAGACCATGCCTATGAGAC CTATTTCGCAAATCAGACTTATTATAAGGTGATAAATATGGATGGGAGGCTGGCAAACCCTGACCAGTCT CTTACCGAAGACATTATGATGTTCTCGCAATCTGTGGCTCACCTGTATTCCAACCTTACCAAACCTATTT TAGATGTCATTCTAACCTCCTATACTCTCATCCGGACAGCTACATCCAGAGGAGCAAGCCCTATAGGGCC CACCCTGTTAGCAGGACTTGTCGTGTATGCCACTGCTAAAGTACTGAAAGCTTGCTCGCCCAAATTTGGT TCGCTGGTGGCTGAAGAAGCCCACAGGAAAGGCTACCTGCGGTATGTCCACTCCCGAATCATAGCCAATG TAGAAGAAATTGCCTTCTACAGAGGACATAAGGTAGAAATGAAGCAGCTGCAGAAATGTTACAAGGCTTT AGCTTACCAGATGAACCTGATTTTATCCAAACGTTTATGGTACATCATGATAGAACAATTCTTGATGAAG TATGTGTGGAGCAGCTGTGGACTAATTATGGTGGCTATACCCATTATCACTGCAACGGGCTTTGCAGATG GTGATCTGGAGGATGGTCCAAAGCAGGCTATGGTTAGCGATCGGACAGAGGCCTTCACCACTGCCCGGAA CTTACTGGCCTCTGGAGCTGATGCAATTGAAAGGATTATGTCTTCATACAAAGAGATCACTGAACTAGCA GGTTATACTGCTAGAGTATACAATATGTTCTGGGTCTTCGATGAAGTGAAGAGAGGCATTTATAAGAGAA CTGTCACTCAGGAACCTGAAAACCATAGCAAGCGTGGAGGTAACCTGGAACTACCCCTCAGCGACACCCT GGCCATCAAAGGAACAGTTATTGATGTGGATCATGGAATCATTTGTGAAAATGTTCCCATAATTACACCA GCGGGCGAAGTGGTGGCTTCCAGGCTAAACTTCAAAGTGGAAGAAGGGATGCATCTCTTGATAACTGGTC CCAACGGTTGTGGGAAAAGCTCTCTCTTCAGAATCTTAAGCGGGCTGTGGCCTGTGTATGAAGGAGTCCT TTATAAACCGCCTCCCCAACATATGTTCTATATTCCACAGAGGCCATACATGTCTCTTGGAAGTCTCCGG GATCAAGTCATTTACCCTGACTCAGCGGATGACATGCGTGAGAAAGGTTACACTGACCAAGACCTAGAAC GCATCCTGCACAGCGTGCACCTCTACCACATAGTTCAAAGAGAAGGAGGATGGGATGCAGTCATGGACTG GAAAGATGTCCTTTCCGGAGGGGAGAAGCAGAGAATGGGCATGGCGCGGATGTTTTACCATAAACCGAAG TATGCATTGCTGGATGAATGTACCAGTGCCGTGAGCATCGACGTTGAAGGAAAGATATTTCAGGCTGCTA TTGGGGCTGGGATTTCCCTACTCTCCATAACACACAGGCCTTCTCTGTGGAAATACCACACTCATCTATT ACAATTCGATGGCGAAGGAGGCTGGCGCTTTGAACAGTTGGACACTGCTATCCGTTTAACGTTGAGTGAG GAAAAGCAAAAGTTGGAGTCGCAGCTCGCTGGAATTCCCAAAATGCAACAGAGACTCAACGAACTATGCA AAATTCTGGGGGAAGACTCGGTGCTGAAAACAATCCAAACTCCAGAAAAGACATCCTAATTTATCTTGAC ATGTTTTCAGTTACCTTCTAGGTGAAGCCTCAGAGACTCTCTCTTTACTGCATGCAGTATGTTAAGCTAA GTGCAGAGAAAGCAAGCCGGCAAAAAAAAAGTATTTTGTATGATTTTAGCATCGAGGAAATATATGAAGA CTTTTCAAACAAACAAACAAAAAAAAAAAAAAA
Restriction Sites	RsrII-NotI
ACCN	BC019187
Insert Size	2226 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC019187, AAH19187
RefSeq Size	2553 bp
RefSeq ORF	2226 bp
Locus ID	26874
Gene Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of Abcd1 and/or other peroxisomal ABC transporters. Mutations in the human gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

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