Slc8b1 (NM_133221) Mouse Untagged Clone
CAT#: MC219330
Slc24a6 (untagged) - Mouse solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (Slc24a6), transcript variant 1, (10ug)
CNY 7,410.00
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | AF261233; NCKX6; NCLX; Slc24a6 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC219330 representing NM_133221
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCAAGCAGATGGCTGGCTCTGCTCTGGGCTCCTGTCTTCCTCTGTGTGGCTCTGATACTGGAGACGG CGTCTGGGACCGGAGACCCATCCACAAAAGCCCATGGACACATCCAGTTTTCAGCTGGAAGTGTCAACCA GACTGCCATGGCGGATTGCCGAGCCGTGTGTGGCCTGAACACATCTGATCGCTGTGACTTTGTCAGGAGG AATCCGGACTGCCGCAGCGAGGCGGGCTACCTGGACTACCTTGAGGGCATCTTCTGCTACTTCCCCCCCA ACCTCCTCCCTCTGGCCATCACCCTCTACGTTTTCTGGCTGCTTTACCTCTTTCTGATCCTGGGAGTCAC CGCGGCCAAGTTCTTCTGCCCTAACCTGTCAGCCATCTCCACTAACCTCAAACTCTCCCACAACGTGGCA GGTGTCACCTTCCTGGCCTTTGGAAATGGCGCTCCAGACATCTTCAGTGCTTTAGTGGCTTTCTCAGACC CACGTACTGCCGGCCTGGCCATCGGGGCTCTGTTTGGTGCAGGGGTGCTGGTCACCACTGTGGTGGCTGG AGGCATCACCATCCTGCATCCCTTCATGGCTGCCTCCAGGCCCTTCCTCAGGGACATCGCTTTCTACATG GTGGCTGTGTTCCTAACCTTCACTGCACTCTATCTCGGCAGGATCACGCTGACGTGGGCGCTGGGTTACC TGGGCCTCTACGTGTTCTACGTGGTCACGGTCATCATCTGCACTTGGGTCTACCAACGGCAGCGAAGCAG GTCTCTGGTCCACTCCATATCGGAGACACCAGAGTTGCTGTCTGAGTCAGAGGAGGACCAGATGTCTTCC AACACCAACAGCTATGACTATGGAGATGAATACCGGCCTCTGTTGCTGGGTCGGGAGACCACTGTCCAGA TCCTGATCCAAGCCCTGAATCCCTTGGACTACAGGAAGTGGAGAACTCAGTCGATATCCTGGAGGGTCCT GAAGGTAGTCAAGTTGCCTGTGGAGTTCTTGTTGCTGCTCACAGTACCGGTTGTGGACCCCGACAAGGAC GATCGGAATTGGAAACGGCCACTCAACTGTCTGCAGCTGGTCATCAGCCCCCTGGTCCTGGTCCTGACCC TGCAGTCGGGGGTCTATGGCATCTATGAGATCGGCGGTCTCCTTCCTGTCTGGGCTGTGGTGGTGATCGT GGGCACAGCGCTGGCTTCAGTGACCTTCTTTGCCACGTCTAACAGAGAACCCCCTAGACTGCACTGGCTC TTTGCTTTCCTGGGTTTCCTGACCAGTGCCCTGTGGATCAATGCAGCCGCCACAGAGGTGGTGAACATAT TACGGTCCCTGGGTGTGATCTTCCGCCTGAGCAACACCGTCCTAGGGCTGACCCTCCTGGCCTGGGGAAA CAGCATTGGAGATGCCTTCTCAGATTTCACGCTGGCCCGCCAAGGATACCCTCGGATGGCCTTCTCCGCC TGTTTCGGGGGCATCATCTTCAACATCCTGGTTGGTGTGGGGCTGGGCTGCTTGCTGCAGATCATCAGGA ACCACGTTGTGGAGGTGAAGCTGGAGCCAGACGGATTACTGGTGTGGGTGCTGGCCAGTGCCCTGGGCCT CAGCTTGATCTTCTCCCTGGTCTCCGTGCCGCTTCAGTGTTTCCAGCTCAGCAAGGCTTACGGCCTCTGC CTCCTCCTCTTCTACATCTGTTTCCTTGTTGTGGTCCTGCTCACAGAGTTTGGGGTGATTCACCTGAAGA AGGCGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_133221 |
Insert Size | 1758 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_133221.2, NP_573484.2 |
RefSeq Size | 2893 bp |
RefSeq ORF | 1758 bp |
Locus ID | 170756 |
UniProt ID | Q925Q3 |
Gene Summary | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:28445457). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:24067497, PubMed:28445457). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG223948 | Slc24a6 (tGFP-tagged) - Mouse solute carrier family 24 (sodium/potassium/calcium exchanger) member 6 (Slc24a6) transcript variant 1, (10ug) |
CNY 5,960.00 |
|
MR223948 | Slc24a6 (Myc-DDK-tagged) - Mouse solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (Slc24a6), transcript variant 1 |
CNY 4,360.00 |
|
MR223948L3 | Lenti ORF clone of Slc24a6 (Myc-DDK-tagged) - Mouse solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (Slc24a6), transcript variant 1 |
CNY 7,030.00 |
|
MR223948L4 | Lenti ORF clone of Slc24a6 (mGFP-tagged) - Mouse solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (Slc24a6), transcript variant 1 |
CNY 7,030.00 |