Mapk8ip3 (NM_001163450) Mouse Untagged Clone

CAT#: MC224199

Mapk8ip3 (untagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 5, (10ug)



  "NM_001163450" in other vectors (4)

CNY 16,820.00


货期*
7周

规格
    • 10 ug

Product images

经常一起买 (4)
Goat Anti-MAPK8IP3 / JIP3 Antibody
    • 100 ug

CNY 5,371.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC224199 representing NM_001163450
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGATGGAGATCCAGATGGACGAGGGAGGAGGAGTGGTGGTGTACCAAGACGACTACTGCTCGGGCTCGG
TCATGTCGGAGCGTGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATTCACTGCTA
TGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTTGACTCGGTGCTG
AGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTCCTACGCGAGGACAACGAGCAGCTGCTCACGCAAT
ACGAGCGCGAGAAGGCGCTGCGCAAACAGGCCGAGGAGAAATTCATCGAATTTGAAGATGCCTTGGAACA
AGAGAAGAAAGAACTCCAGATCCAGGTAGAACATTATGAGTTTCAGACACGCCAGCTGGAGCTAAAGGCC
AAAAACTATGCAGATCAGATTTCCCGACTGGAGGAACGAGAATCGGAGATGAAGAAGGAATACAATGCCC
TGCACCAGCGGCACACAGAGATGATCCAGACCTATGTGGAACACATTGAAAGATCCAAGATGCAGCAAGT
TGGGGGTAGCGGCCAAACAGAAAGCAGCCTGCCCGGGCGGAGCAGGAAGGAGCGTCCCACCTCTCTGAAT
GTCTTCCCCCTGGCTGATGGCATGTGTCCAAATGATGAGATGTCTGAGTCAGGCCAGTCCTCAGCAGCTG
CAACACCCAGTACCACAGGTACCAAGTCCAACACACCCACGTCCTCCGTGCCCTCAGCAGCAGTCACGCC
ACTCAACGAGAGCCTACAGCCCCTGGGGGACTATGTCAGTGTCACAAAGAACAACAAGCAGGCCCGAGAG
AAGCGCAATAGCCGTAACATGGAGGTCCAGGTCACCCAAGAGATGCGGAACGTCAGTATCGGCATGGGCA
GCAGTGACGAGTGGTCCGATGTTCAGGACATTATCGACTCCACCCCAGAGCTGGATGTGTGTCCTGAAAC
CCGTCTGGAGCGCACAGGAAGCAGCCCAACCCAGGGAATTGTAAACAAAGCTTTTGGAATCAACACTGAC
TCCTTGTATCACGAACTCTCCACGGCGGGATCTGAGGTCATCGGGGATGTGGACGAGGGAGCTGATCTCC
TAGGGGAGTTTTCAGTGCGCGATGATTTTTTTGGAATGGGCAAAGAAGTGGGGAACCTGCTGCTGGAGAA
CTCACAGCTTCTAGAGACAAAAAATGCTTTAAATGTAGTGAAGAATGACCTCATTGCTAAGGTTGACCAA
CTGTCAGGAGAACAGGAGGTCCTGAAGGGTGAGCTGGAAGCAGCCAAGCAAGCCAAAGTCAAGCTGGAGA
ACCGAATCAAAGAGCTTGAAGAAGAACTGAAGAGAGTCAAGTCAGAGGCAGTAACTGCCCGCCGTGAGCC
CAGAGAAGAGGTGGAGGATGTAAGCAGCTATCTCTGTACAGAATTGGACAAAATCCCCATGGCCCAGCGC
CGACGCTTCACACGGGTGGAGATGGCCCGAGTGCTCATGGAACGCAACCAGTACAAGGAACGCCTCATGG
AGCTGCAGGAGGCTGTGAGGTGGACTGAAATGATCAGAGCATCAAGGGAACACCCATCTGTCCAGGAGAA
GAAGAAGTCCACCATCTGGCAGTTCTTTAGTCGCCTCTTCAGCTCCTCATCTAGCCCCCCTCCGGCCAAA
CGATCCTACCCATCTGTGAACATTCACTACAAGTCACCCACTGCAGCTGGCTTTAGCCAGCGTCGCAGCC
ATGCTTTGTGCCAGATCTCAGCCGGCAGCAGGCCCCTGGAGTTCTTCCCTGATGATGACTGCACCTCTTC
TGCCCGGCGGGAGCAGAAGCGGGAGCAGTACCGCCAGGTTCGTGAACACGTGCGCAATGATGACGGGAGG
CTGCAGGCCTGTGGGTGGAGCCTGCCTGCCAAGTACAAGCAGCTGAGCCCCAATGGAGGCCAGGAAGACA
CCCGGATGAAAAATGTGCCTGTCCCTGTGTACTGCCGCCCTCTGGTGGAGAAGGACCCTTCGACAAAGCT
GTGGTGTGCTGCTGGTGTCAACCTGAGTGGGTGGAAGCCACATGAAGAGGACTCTAGCAATGGACCCAAG
CCTGTACCAGGTCGAGACCCTCTGACCTGTGACCGGGAAGGAGAAGGCGAACCCAAGAGCACACACCCAT
CACCTGAGAAGAAGAAGGCAAAGGAAACCCCTGAGGCAGATGCTACCTCCAGTCGGGTATGGATCCTCAC
CAGCACCCTGACAACCAGCAAGGTGGTGATCATTGATGCCAACCAGCCAGGCACAATTGTGGATCAGTTC
ACAGTCTGCAATGCCCACGTCCTGTGTATCTCCAGCATTCCTGCGGCCAGTGACAGTGACTATCCCCCTG
GGGAGATGTTCCTAGACAGTGATGTGAACCCTGAAGATTCAGGTGCTGATGGTGTGCTGGCTGGCATCAC
CCTGGTGGGGTGTGCTACCCGCTGCAATGTTCCACGTAGCAACTGTTCCTCACGAGGAGACACCCCAGTA
CTGGACAAGGGGCAGGGGGATGTGGCGACCACTGCCAATGGGAAGGTCAACCCGTCCCAATCCACAGAAG
AAGCCACAGAAGCCACGGAGGTGCCAGACCCTGGTCCCAGCGAGTCAGAAGCAACGACAGTCCGGCCCGG
GCCTCTCACAGAGCATGTCTTTACTGACCCAGCACCCACCCCATCCTCCAGCACCCAGCCTGCCAGTGAG
AATGGGTCAGAGTCCAATGGCACCATTGTACAGCCTCAGGTGGAGCCCAGTGGGGAACTCTCAACAACAA
CCAGTAGCGCTGCACCCACTATGTGGCTAGGAGCCCAGAATGGCTGGCTCTATGTGCATTCAGCGGTAGC
CAACTGGAAGAAGTGTCTGCACTCCATCAAGCTAAAAGACTCTGTGCTGAGCCTGGTGCATGTCAAAGGC
CGAGTGCTGGTAGCTCTTGCAGATGGGACCCTGGCTATCTTCCATCGTGGAGAGGATGGCCAGTGGGACC
TGAGCAACTACCACCTAATGGACCTGGGCCACCCACACCACTCCATCCGCTGCATGGCTGTTGTGAATGA
CCGAGTTTGGTGTGGCTACAAGAACAAGGTGCATGTTATCCAGCCCAAGACAATGCAGATTGAGAAATCA
TTTGATGCCCACCCAAGGCGGGAAAGCCAGGTACGTCAGCTGGCCTGGATCGGTGATGGAGTGTGGGTCT
CTATTCGCTTGGATTCTACCCTTCGGCTCTACCATGCTCACACCCACCAGCACCTGCAGGATGTGGACAT
TGAGCCCTATGTTAGCAAGATGCTAGGAACCGGCAAGCTGGGCTTCTCCTTCGTGCGCATCACAGCCTTA
CTCATTGCAGGCAACCGTCTGTGGGTGGGCACTGGCAATGGGGTTGTCATCTCCATCCCCTTGACTGAGA
CTGTGGTCCTGCATCGAGGCCAGCTCCTAGGGCTCCGAGCCAACAAGACATCCCCAACATCTGGGGAGGG
GACCCGCCCAGGGGGCATCATCCATGTGTATGGGGACGACAGCAGTGACAAGGCCGCCAGTAGTTTCATC
CCCTACTGCTCCATGGCACAGGCTCAGCTTTGCTTCCATGGGCACCGTGATGCTGTCAAATTCTTTGTCT
CTGTGCCAGGAAATGTGCTGGCCACTCTCAATGGCAGTGTGCTAGACAGCCCATCAGAGGGCCCTGGGCC
TGCTGCACCCGCTGCAGATGCTGAGGGCCAGAAGTTGAAGAATGCACTGGTGCTGAGTGGTGGTGAAGGT
TACATTGACTTCCGTATCGGAGACGGAGAGGATGATGAAACTGAGGAATGTGCCGGGGACGTGAACCAGA
CAAAGCCCTCGTTGTCCAAGGCTGAGCGCAGCCACATCATCGTGTGGCAGGTGTCCTACACCCCTGAGTG
A


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_001163450
Insert Size 3921 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_001163450.1, NP_001156922.1
RefSeq Size 5486 bp
RefSeq ORF 3921 bp
Locus ID 30957
Gene Summary The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553).[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform e) compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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