Brca2 (NM_009765) Mouse Untagged Clone

CAT#: MC225477

Brca2 (untagged) - Mouse breast cancer 2 (Brca2), transcript variant 2, (10ug)



  "NM_009765" in other vectors (2)

CNY 53,390.00


货期*
12周

规格
    • 10 ug

Product images

经常一起买 (2)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms Fancd1; RAB163
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC225477 representing NM_009765
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCCCGTTGAATACAAAAGGAGACCAACTTTTTGGGAAATTTTTAAGGCGAGATGCAGCACAGCAGATT
TAGGACCGATAAGCCTCAATTGGTTTGAGGAGCTTTCCTCAGAAGCCCCCCCATACAATTCTGAACCTCC
GGAGGAATCTGAGTATAAGCCCCACGGTTATGAACCACAGCTGTTTAAAACACCACAGAGGAATCCCCCC
TACCATCAGTTTGCTTCAACTCCAATAATGTTCAAAGAACGAAGTCAAACTCTACCACTGGACCAGTCGC
CTTTCAGAGAATTAGGGAAGGTTGTTGCAAGTAGTAAACATAAAACTCACAGCAAAAAGAAGACCAAAGT
GGACCCTGTGGTAGATGTTGCTAGTCCGCCTCTGAAATCTTGTCTCAGTGAAAGCCCTCTTACTCTGCGG
TGCACACAGGCAGTACTACAACGAGAAAAGCCAGTGGTATCTGGAAGTTTATTTTATACACCAAAACTCA
AGGAGGGTCAGACACCAAAACCTATTTCTGAGAGTCTGGGAGTTGAAGTGGATCCTGATATGTCTTGGAC
AAGCTCATTAGCTACACCACCAACCCTTAGTTCCACTGTGCTCATAGCCCGAGATGAAGAAGCACGCAGC
TCTGTAACGCCTGCTGACTCTCCCGCTACTTTGAAAAGCTGTTTTTCTAACCACAATGAAAGTCCACAAA
AAAATGATAGATCTGTTCCCTCAGTGATTGACAGTGAAAACAAAAACCAGCAAGAAGCTTTTAGTCAGGG
TTTGGGGAAAATGTTAGGAGATTCATCTGGCAAAAGAAATAGCTTCAAAGACTGCCTTAGAAAGCCAATA
CCAAATATTCTAGAAGATGGGGAGACAGCTGTTGATACTTCCGAAGAAGATAGTTTCTCATTATGTTTTC
CTAAGCGTAGAACCAGAAATCTACAGAAAATGAGAATGGGCAAGACAAGGAAAAAAATTTTCAGTGAAAC
AAGAACTGATGAATTAAGCGAAGAAGCTAGAAGACAAACTGATGATAAAAACTCATTTGTATTTGAAATG
GAACTAAGAGAGAGTGATCCTTTAGATCCAGGTGTAACAAGCCAGAAGCCCTTTTACAGCCAGAATGAGG
AAATCTGCAATGAAGCTGTACAGTGTTCAGATAGTAGATGGTCTCAGTCAAACCTTTCTGGTCTAAATGA
AACCCAGACAGGAAAAATAACCTTACCTCATATTTCTTCTCATAGCCAAAATATTTCAGAAGACTTCATA
GATATGAAGAAAGAAGGTACTGGCTCTATTACTTCAGAAAAATCTTTACCTCATATTTCTAGTCTTCCAG
AACCGGAAAAGATGTTCAGTGAGGAGACTGTGGTAGATAAGGAACATGAAGGACAGCATTTTGAATCACT
TGAAGACTCCATTGCAGGGAAGCAAATGGTGTCTAGAACAAGTCAAGCAGCCTGTCTTTCTCCGAGTATC
AGGAAGTCTATATTCAAGATGAGAGAGCCACTTGACGAGACTTTGGGTACTGTTTTCTCAGATAGTATGA
CCAACTCAACCTTTACAGAAGAACATGAAGCCTCTGCATGTGGATTGGGAATACTTACTGCATGCTCACA
GAGAGAGGATTCTATATGTCCTAGTTCAGTTGACACTGGAAGCTGGCCAACCACTCTCACTGACACTTCT
GCCACTGTGAAAAATGCAGGTTTGATATCCACTCTAAAAAATAAAAAAAGAAAGTTTATTTACTCTGTAA
GTGATGATGCATCTCTTCAAGGAAAAAAACTACAGACACACAGACAGTTAGAGCTTACTAATCTTTCAGC
CCAGCTTGAAGCAAGTGCTTTTGAAGTACCATTGACCTTTACAAATGTAAATTCAGGTATACCAGATTCT
TCTGACAAAAAACGCTGTTTACCGAATGATCCTGAAGAGCCATCCTTGACCAACTCTTTTGGGACTGCTA
CCAGTAAAGAAATTAGTTATATTCATGCATTGATATCTCAGGATCTTAATGACAAAGAAGCAATAGTCAT
TGAAGAAAAACCACAGCCATATACAGCCCGAGAAGCTGACTTTCTGTTATGCTTGCCAGAAAGAACATGT
GAAAATGACCAAAAAAGTCCAAAAGTTTCCAATGGAAAAGAAAAAGTCTTAGTTTCAGCATGTCTTCCTT
CAGCAGTGCAACTCAGCAGCATTAGCTTTGAATCACAGGAAAACCCTCTTGGTGACCACAACGGAACAAG
TACTCTTAAATTAACTCCCAGCTCAAAGCTACCTCTGTCAAAGGCAGACATGGTTTCTAGAGAGAAAATG
TGTAAAATGCCAGAGAAACTGCAATGTGAGAGTTGTAAAGTTAATATTGAACTAAGTAAAAACATCTTGG
AGGTAAATGAAATATGTATCTTAAGTGAAAATTCTAAAACTCCTGGGCTTCTGCCACCTGGTGAAAATAT
AATAGAAGTGGCCTCTTCAATGAAGTCACAGTTCAATCAAAATGCAAAAATAGTCATACAGAAGGACCAA
AAAGGCTCACCTTTTATTTCAGAAGTAGCAGTCAATATGAACTCTGAAGAACTTTTCCCAGACAGTGGGA
ATAATTTTGCTTTTCAAGTAACTAATAAATGCAATAAGCCTGATTTAGGAAGTTCAGTGGAACTCCAGGA
AGAAGACCTCAGCCACACACAAGGGCCTAGTCTCAAGAACTCTCCCATGGCAGTAGATGAAGATGTAGAT
GATGCGCATGCAGCCCAAGTGTTGATTACAAAGGACTCAGATTCATTAGCTGTGGTCCATGATTATACAG
AGAAGAGCAGAAATAATATAGAGCAGCACCAGAAAGGAACCGAAGACAAAGATTTCAAGTCAAATTCCTC
CTTGAATATGAAATCAGATGGGAACAGTGATTGTTCAGACAAATGGTCAGAGTTCTTGGATCCAGTCTTG
AACCATAATTTTGGAGGTAGCTTCAGAACAGCTTCCAATAAAGAAATAAAACTTTCAGAGCATAATGTCA
AGAAAAGTAAAATGTTCTTCAAAGATATTGAAGAACAGTATCCTACTAGGTTAGCTTGTATTGACATTGT
TAATACCCTTCCATTAGCAAACCAGAAGAAACTAAGTGAACCTCATATATTTGATTTGAAATCAGTTACT
ACTGTATCTACACAGTCTCACAATCAATCATCTGTTTCTCATGAAGATACTGACACAGCACCTCAGATGT
TATCTTCAAAGCAAGATTTTCATTCAAATAATTTAACGACCAGCCAAAAAGCAGAAATTACAGAACTGTC
TACTATTTTGGAAGAATCAGGAAGTCAGTTTGAATTCACACAGTTCAGAAAGCCAAGCCACATAGCACAG
AATACATCTGAAGTGCCTGGAAACCAGATGGTTGTTTTAAGTACCGCTTCTAAGGAGTGGAAAGATACTG
ATCTTCACCTCCCAGTGGATCCCTCTGTAGGTCAGACAGATCACAGCAAGCAATTTGAAGGTTCGGCTGG
AGTTAAACAAAGCTTTCCTCACCTGTTAGAAGACACTTGTAACAAAAATACATCTTGTTTTTTACCAAAT
ATAAATGAAATGGAGTTTGGAGGATTTTGTTCTGCTCTTGGCACAAAACTTAGTGTGTCTAATGAGGCTC
TGAGAAAAGCTATGAAACTGTTCAGTGACATTGAAAATAGTGAGGAGCCTTCTGCAAAAGTAGGACCAAG
AGGATTCTCTTCAAGTGCACACCATGATTCTGTTGCTTCAGTGTTTAAGATAAAGAAACAAAACACTGAA
AAAAGTTTTGATGAAAAATCTAGTAAGTGCCAAGTAACATTACAAAATAATATTGAAATGACTACCTGTA
TTTTTGTTGGCAGAAATCCTGAAAAATACATAAAGAATACAAAACATGAAGATAGCTATACTAGCTCTCA
AAGAAATAATTTAGAAAACTCTGATGGTAGTATGTCAAGTACAAGTGGCCCAGTTTATATTCATAAAGGT
GACAGTGATTTACCTGCCGATCAAGGCAGTAAGTGTCCTGAGTCATGTACCCAATATGCGAGAGAGGAAA
ACACACAAATTAAGGAAAATATATCAGATTTAACATGTTTGGAAATTATGAAAGCTGAGGAAACATGTAT
GAAATCTTCAGATAAAAAACAATTACCTTCAGATAAGATGGAACAAAATATAAAAGAGTTTAATATATCC
TTTCAGACTGCAAGTGGGAAAAATACCAGAGTCTCCAAAGAGTCATTAAATAAAAGTGTGAATATTTTTA
ATCGGGAAACAGATGAATTGACTGTCATTTCAGATTCTTTGAATTCTAAAATTCTCCATGGCATAAATAA
GGACAAAATGCATACTTCATGTCACAAGAAAGCAATCAGTATTAAAAAGGTATTTGAAGACCATTTCCCA
ATTGTAACTGTCAGTCAATTACCAGCTCAGCAGCATCCTGAATATGAAATAGAAAGTACCAAAGAACCTA
CTCTGTTGAGTTTTCATACAGCTAGTGGGAAAAAAGTCAAAATTATGCAGGAATCTTTGGACAAAGTGAA
AAACCTTTTTGATGAGACACAATATGTTAGGAAAACTGCCAGTTTTAGTCAAGGATCAAAACCCCTGAAG
GACAGTAAAAAAGAACTTACATTAGCATATGAGAAAATTGAAGTAACTGCCTCAAAATGTGAAGAAATGC
AGAACTTTGTCTCTAAGGAGACTGAAATGCTACCTCAGCAAAATTATCATATGTATAGGCAAACTGAAAA
TCTCAAAACATCAAATGGTACCTCTTCCAAAGTACAAGAAAACATAGAAAATAATGTAGAAAAGAATCCT
AGAATTTGCTGTATTTGTCAGTCCTCTTACCCAGTCACTGAAGATTCTGCTTTGGCATATTATACGGAGG
ACAGTAGGAAAACTTGTGTCAGAGAGTCTTCTCTATCCAAAGGCAGAAAATGGCTTAGAGAACAGGGTGA
TAAGCTTGGAACAAGAAATACTATCAAAATTGAGTGTGTAAAGGAACACACAGAAGATTTTGCAGGAAAT
GCCTCATATGAACATAGTTTGGTCATTATCAGAACTGAAATTGATACAAATCATGTCTCTGAAAACCAAG
TGTCAACCCTCCTTAGTGACCCTAATGTGTGTCATAGCTATCTATCCCAGTCTAGTTTTTGTCATTGTGA
TGACATGCATAATGATTCAGGATATTTCTTAAAAAATAAAATTGATTCTGACGTTCCGCCAGACATGAAG
AATGCTGAAGGCAATACCATTTCCCCCAGAGTATCTGCTACAAAAGAAAGAAATCTACACCCACAAACTA
TAAATGAATATTGTGTTCAGAAACTGGAGACTAATACTTCACCACATGCAAATAAAGATGTAGCCATTGA
CCCATCTCTGCTGGATTCAAGGAATTGTAAGGTAGGCTCACTCGTGTTTATTACAGCTCATTCACAAGAA
ACTGAAAGAACAAAAGAGATAGTCACAGATAACTGTTATAAAATAGTTGAGCAAAACAGACAGAGTAAAC
CAGACACTTGCCAGACAAGCTGTCATAAAGTATTGGATGATTCAAAGGATTTTATATGTCCTAGCTCTTC
AGGTGATGTCTGCATAAACTCACGTAAGGATAGTTTTTGTCCTCATAATGAACAAATTTTACAACATAAC
CAAAGTATGTCTGGACTGAAGAAAGCTGCAACACCACCTGTTGGTTTGGAAACTTGGGATACAAGTAAAT
CTATAAGAGAACCTCCCCAGGCAGCCCATCCTTCACGCACTTATGGGATTTTTAGCACAGCAAGTGGAAA
AGCTATACAAGTATCAGATGCTTCATTAGAAAAGGCAAGGCAAGTGTTTTCTGAGATGGATGGTGATGCT
AAACAGTTATCTTCCATGGTGTCACTGGAAGGTAATGAAAAACCACATCACTCTGTGAAAAGAGAAAACT
CTGTGGTGCATAGCACCCAGGGTGTATTGTCACTCCCAAAACCCCTCCCAGGCAATGTCAATTCATCTGT
ATTCTCTGGATTTAGCACTGCAGGTGGAAAACTGGTCACAGTTTCAGAAAGTGCCTTACACAAAGTTAAA
GGAATGTTAGAGGAGTTTGATTTGATCAGAACTGAACATACTCTCCAGCATTCACCTATACCTGAAGACG
TATCAAAAATACTTCCTCAACCTTGTGCTGAAATCAGAACCCCAGAATACCCTGTAAACTCAAAATTGCA
GAAAACCTACAATGATAAATCCAGCTTACCAAGTAATTATAAAGAAAGTGGTTCTTCGGGCAATACTCAA
TCTATTGAAGTTTCTCTCCAACTCTCTCAGATGGAGAGAAACCAAGACACACAGTTGGTATTAGGAACAA
AAGTATCCCATAGTAAGGCTAATCTTTTGGGAAAAGAACAAACTTTACCCCAAAACATAAAAGTAAAAAC
TGATGAAATGAAAACATTTTCTGATGTTCCTGTGAAAACAAATGTAGGAGAGTATTACTCCAAAGAGTCA
GAGAACTATTTTGAAACAGAAGCAGTGGAGAGTGCCAAAGCTTTTATGGAAGATGATGAGCTGACAGATT
CTGAACAGACTCATGCCAAATGCTCACTGTTTACATGCCCCCAAAATGAGACTTTGTTTAATTCGAGAAC
TAGGAAAAGAGGAGGAGTGACTGTTGACGCAGTTGGACAACCCCCAATCAAAAGAAGCTTATTAAATGAA
TTTGACAGGATAATAGAAAGTAAAGGAAAATCCTTAACACCTTCAAAAAGCACTCCAGATGGCACAGTAA
AAGACAGAAGCTTGTTCACACACCACATGTCTTTAGAGCCGGTTACCTGTGGACCCTTCTGCTCAAGTAA
AGAAAGGCAAGGAGCCCAGCGCCCACATCTTACCTCACCTGCTCAAGAGCTTCTGTCTAAAGGGCATCCC
TGGAGACACTCAGCTTTGGAAAAGTCTCCAAGCAGTCCTATAGTTTCAATCTTACCGGCTCACGACGTTT
CTGCCACAAGAACCGAAAGGACCAGACATTCAGGCAAATCCACCAAAGTCTTCGTCCCGCCTTTCAAGAT
GAAATCACAGTTTCACGGAGATGAACATTTCAATAGCAAGAACGTTAATTTGGAGGGAAAGAACCAAAAG
AGCACAGATGGAGACAGGGAAGACGGGAACGACAGCCATGTTCGTCAGTTTAACAAAGATTTAATGTCAA
GCCTTCAGAGTGCCAGAGACCTACAGGATATGCGAATTAAAAACAAAGAAAGGCGACATCTCCGTCTGCA
GCCAGGCAGTCTGTATCTTACAAAGTCATCCACCCTGCCCCGGATCTCCCTGCAGGCTGCAGTAGGAGAC
AGGGCTCCTTCTGCATGTTCTCCTAAGCAGCTCTATATATACGGCGTTTCTAAAGAGTGCATAAACGTTA
ATAGCAAAAATGCTGAGTATTTTCAGTTTGATATTCAGGATCATTTTGGTAAAGAAGATCTGTGTGCTGG
CAAAGGCTTTCAGTTGGCAGATGGTGGATGGCTGATCCCCTCCAATGATGGCAAGGCTGGAAAAGAAGAA
TTTTATAGGGCTCTGTGTGACACTCCAGGTGTGGATCCAAAGCTTATTTCTAGCATCTGGGTTGCTAACC
ATTACAGGTGGATTGTATGGAAACTGGCAGCTATGGAATTTGCTTTTCCTAAGGAATTTGCTAATAGATG
CCTAAACCCAGAAAGAGTGCTGCTTCAACTGAAATACAGATACGATGTGGAAATTGACAACAGCAGGAGA
TCGGCTCTAAAGAAGATACTGGAGAGGGATGACACAGCTGCAAAAACCCTTGTTCTCTGTATTTCTGACA
TCATTTCACCAAGCACAAAGGTGTCTGAAACTTCAGGCGGTAAAACTAGTGGTGAGGATGCCAACAAAGT
GGACACGATCGAACTCACAGATGGGTGGTACGCTGTCAGGGCCCAGCTAGACCCTCCACTCATGGCTCTT
GTAAAGAGTGGCAAACTGACTGTGGGTCAGAAGATCATTACTCAGGGAGCAGAGCTGGTGGGCTCTCCTG
ATGCCTGTGCACCTCTGGAAGCCCCAGACTCCCTAAGGCTAAAGATTTCTGCAAACAGCACAAGGCCTGC
TCGCTGGCACAGCAGGCTGGGGTTCTTTCGTGACCCCAGGCCCTTCCCTCTGCCCTTGTCCTCACTGTTC
AGTGACGGAGGAAATGTTGGCTGTGTGGATATCATTGTTCAGAGAGTGTACCCTTTACAGTGGGTGGAGA
AGACAGTGTCTGGATTGTACATATTTCGTAGTGAGAGAGAAGAGGAGAAGGAAGCACTGAGATTTGCAGA
GGCCCAGCAGAAGAAACTAGAGGCCTTGTTCACCAAAGTCCACACAGAGTTTAAAGACCACGAAGAAGAC
ACAACACAGCGGTGTGTGCTGTCCCGCACACTCACACGGCAGCAAGTCCATGCTCTGCAGGATGGAGCAG
AGCTCTATGCAGCAGTGCAGTATGCATCAGACCCAGATCACCTTGAGGCTTGTTTCAGCGAAGAGCAGCT
AAGAGCCTTGAACAACTACAGACAAATGCTGAATGATAAGAAACAAGCGCGGATCCAGTCAGAATTCCGG
AAGGCCCTGGAATCCGCTGAGAAAGAGGAGGGTTTATCAAGGGATGTTACAACTGTGTGGAAGCTGCGGG
TTACAAGCTACAAGAAAAAGGAAAAATCAGCTCTGTTGAGTATCTGGCGTCCATCATCAGACTTATCCTC
CCTGTTAACAGAAGGAAAGAGATACAGAATCTATCATCTTGCAGTGTCAAAATCGAAGAGTAAATTTGAA
CGGCCCAGCATCCAGTTAACAGCCACAAAAAGAACTCAGTATCAACAGCTGCCGGTTTCCAGTGAGACTT
TACTCCAGGTTTACCAGCCCAGGGAGTCCCTTCACTTCAGCAGACTGTCAGACCCAGCCTTTCAGCCTCC
TTGTTCTGAAGTGGATGTCGTAGGAGTTGTAGTTTCTGTTGTAAAACCGATAGGTCTTGCTCCTTTGGTC
TACCTGTCAGACGAGTGCCTTAATTTATTAGTGGTGAAATTCGGGATAGACCTTAATGAAGACATAAAGC
CACGTGTGCTAATTGCCGCAAGCAACCTCCAGTGCCAGCCAGAATCCACATCAGGAGTGCCGACCTTATT
TGCTGGCCATTTTTCCATATTTTCTGCCAGTCCAAAGGAGGCCTACTTTCAGGAGAAAGTCAACAACTTG
AAGCATGCTATTGAGAATATCGATACATTTTACAAGGAGGCAGAAAAGAAGCTTATACACGTGCTTGAGG
GAGACAGTCCCAAGTGGTCCACACCGAACAAAGACCCCACCCGAGAGCCCCATGCAGCCTCCACTTGCTG
TGCTTCAGATCTCCTTGGTTCAGGAGGTCAGTTCCTGAGGATTTCACCTACTGGTCAGCAAAGTTATCAA
AGTCCTTTATCACACTGCACACTGAAAGGGAAGTCTATGCCCCTGGCTCACTCAGCCCAGATGGCAGCAA
AGTCTTGGAGTGGAGAGAACGAGATTGATGACCCAAAAACCTGTCGAAAAAGAAGAGCCTTGGATTTCCT
AAGTCGGCTGCCCTTACCGTCCCCGGTCAGTCCCATCTGTACCTTTGTCTCTCCAGCTGCACAGAAGGCT
TTTCAGCCGCCACGGAGCTGTGGCACGAAATACGCAACACCTATTAAAAAAGAACCCAGTTCCCCGCGGA
GGAGAACGCCATTTCAGAAGACCAGTGGCGTTTCTCTGCCGGACTGTGATTCAGTAGCTGATGAAGAACT
TGCCTTGCTCAGCACCCAGGCCCTTACGCCTGACTCCGTGGGAGGAAATGAACAAGCGTTTCCCGGTGAT
TCCACAAGGAACCCCCAGCCAGCACAGAGGCCAGACCAGCAAGTAGGGCCCAGGTCCAGGAAGGAGTCTC
TCAGGGACTGTAGAGGCGACAGCAGTGAGAAATTAGCTGTTGAGTCTTAG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_009765
Insert Size 9990 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_009765.3, NP_033895.2
RefSeq Size 10940 bp
RefSeq ORF 9990 bp
Locus ID 12190
UniProt ID P97929
Gene Summary Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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