SLC22A2 (NM_003058) Human Tagged ORF Clone
CAT#: RC207921
SLC22A2 (Myc-DDK-tagged)-Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2)
ORF Plasmid: tGFP
"NM_003058" in other vectors (6)
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CNY 6,200.00
Cited in 7 publications. |
CNY 300.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | OCT2 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC207921 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCCACCACCGTGGACGATGTCCTGGAGCATGGAGGGGAGTTTCACTTTTTCCAGAAGCAAATGTTTT TCCTCTTGGCTCTGCTCTCGGCTACCTTCGCGCCCATCTACGTGGGCATCGTCTTCCTGGGCTTCACCCC TGACCACCGCTGCCGGAGCCCCGGAGTGGCCGAGCTGAGTCTGCGCTGCGGCTGGAGTCCTGCAGAGGAA CTGAACTACACGGTGCCGGGCCCAGGACCTGCGGGCGAAGCCTCCCCAAGACAGTGTAGGCGCTACGAGG TGGACTGGAACCAGAGCACCTTCGACTGCGTGGACCCCCTGGCCAGCCTGGACACCAACAGGAGCCGCCT GCCACTGGGCCCCTGCCGGGACGGCTGGGTGTACGAGACGCCTGGCTCGTCCATCGTCACCGAGTTTAAC CTGGTATGTGCCAACTCCTGGATGTTGGACCTATTCCAGTCATCAGTGAATGTAGGATTCTTTATTGGCT CTATGAGTATCGGCTACATAGCAGACAGGTTTGGCCGTAAGCTCTGCCTCCTAACTACAGTCCTCATAAA TGCTGCAGCTGGAGTTCTCATGGCCATTTCCCCAACCTATACGTGGATGTTAATTTTTCGCTTAATCCAA GGACTGGTCAGCAAAGCAGGCTGGTTAATAGGCTACATCCTGATTACAGAATTTGTTGGGCGGAGATATC GGAGAACAGTGGGGATTTTTTACCAAGTTGCCTATACAGTTGGGCTCCTGGTGCTAGCTGGGGTGGCTTA CGCACTTCCTCACTGGAGGTGGTTGCAGTTCACAGTTGCTCTGCCCAACTTCTTCTTCTTGCTCTATTAC TGGTGCATACCTGAGTCTCCCAGGTGGCTGATCTCCCAGAATAAGAATGCTGAAGCCATGAGAATCATTA AGCACATCGCAAAGAAAAATGGAAAATCTCTACCCGCCTCCCTTCAGCGCCTGAGACTTGAAGAGGAAAC TGGCAAGAAATTGAACCCTTCATTTCTTGACTTGGTCAGAACTCCTCAGATAAGGAAACATACTATGATA TTGATGTACAACTGGTTCACGAGCTCTGTGCTCTACCAGGGCCTCATCATGCACATGGGCCTTGCAGGTG ACAATATCTACCTGGATTTCTTCTACTCTGCCCTGGTTGAATTCCCAGCTGCCTTCATGATCATCCTCAC CATCGACCGCATCGGACGCCGTTACCCTTGGGCTGCATCAAATATGGTTGCAGGGGCAGCCTGTCTGGCC TCAGTTTTTATACCTGGTGATCTACAATGGCTAAAAATTATTATCTCATGCTTGGGAAGAATGGGGATCA CAATGGCCTATGAGATAGTCTGCCTGGTCAATGCTGAGCTGTACCCCACATTCATTAGGAATCTTGGCGT CCACATCTGTTCCTCAATGTGTGACATTGGTGGCATCATCACGCCATTCCTGGTCTACCGGCTCACTAAC ATCTGGCTTGAGCTCCCGCTGATGGTTTTCGGCGTACTTGGCTTGGTTGCTGGAGGTCTGGTGCTGTTGC TTCCAGAAACTAAAGGGAAAGCTTTGCCTGAGACCATCGAGGAAGCCGAAAATATGCAAAGACCAAGAAA AAATAAAGAAAAGATGATTTACCTCCAAGTTCAGAAACTAGACATTCCATTGAAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC207921 protein sequence
Red=Cloning site Green=Tags(s) MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEE LNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFN LVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQ GLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYY WCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMI LMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTN IWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
![]() Sequencher program is needed, download here. |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_003058 |
ORF Size | 1665 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_003058.4 |
RefSeq Size | 2512 bp |
RefSeq ORF | 1668 bp |
Locus ID | 6582 |
UniProt ID | O15244 |
Protein Families | Transmembrane |
MW | 62.6 kDa |
Gene Summary | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] |
Citations (7)
The use of this cDNA Clones has been cited in the following citations: |
---|
Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity
,Hu, S;Leblanc, AF;Gibson, AA;Hong, KW;Kim, JY;Janke, LJ;Li, L;Vasilyeva, A;Finkelstein, DB;Sprowl, JA;Sweet, DH;Schlatter, E;Ciarimboli, G;Schellens, J;Baker, SD;Pabla, N;Sparreboom, A;,
Clin Transl Sci
,PubMed ID 28689374
[SLC22A2]
|
A phosphotyrosine switch regulates organic cation transporters
,Sprowl, JA;Ong, SS;Gibson, AA;Hu, S;Du, G;Lin, W;Li, L;Bharill, S;Ness, RA;Stecula, A;Offer, SM;Diasio, RB;Nies, AT;Schwab, M;Cavaletti, G;Schlatter, E;Ciarimboli, G;Schellens, JH;Isacoff, EY;Sali, A;Chen, T;Baker, SD;Sparreboom, A;Pabla, N;,
Nat Commun
,PubMed ID 26979622
[SLC22A2]
|
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species
,Taub, ME;Ludwig-Schwellinger, E;Ishiguro, N;Kishimoto, W;Yu, H;Wagner, K;Tweedie, D;,
Chem. Res. Toxicol.
,PubMed ID 25489797
[SLC22A2]
|
The involvement of selected membrane transport mechanisms in the cellular uptake of 177Lu-labeled bombesin, somatostatin and gastrin analogues
,Volková, M;Mandíková, J;Láznícková, A;,
Nuclear Medicine and Biology
[SLC22A2]
|
Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice
,Wu, KC;Lu, YH;Peng, YH;Tsai, TF;Kao, YH;Yang, HT;Lin, CJ;,
J. Cereb. Blood Flow Metab.
,PubMed ID 25248837
[SLC22A2]
|
The renal handling of amphotericin B and amphotericin B/deoxycholate and potential renal drug-drug interactions with selected antivirals
,Trejtnar, F;Mandíková, J;Kocíncová, J;Volková, M;,
Antimicrob. Agents Chemother.
,PubMed ID 24957831
[SLC22A2]
|
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
,null,
Toxicology
,PubMed ID 23856525
[SLC22A2]
|
Documents
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SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC207921L1 | Lenti ORF clone of Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2), Myc-DDK-tagged |
CNY 8,600.00 |
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RC207921L2 | Lenti ORF clone of Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2), mGFP tagged |
CNY 8,600.00 |
|
RC207921L3 | Lenti ORF clone of Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2), Myc-DDK-tagged |
CNY 8,600.00 |
|
RC207921L4 | Lenti ORF clone of Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2), mGFP tagged |
CNY 8,600.00 |
|
RG207921 | SLC22A2 (tGFP-tagged) - Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2) |
CNY 7,800.00 |
|
SC126370 | SLC22A2 (untagged)-Human solute carrier family 22 (organic cation transporter), member 2 (SLC22A2) |
CNY 4,144.00 |
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