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Desmocollin 2 (DSC2) (NM_004949) Human Tagged ORF Clone
CAT＃: RC222207
DSC2 (Myc-DDK-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2b
ORF Plasmid: tGFP
"NM_004949" in other vectors (4)
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CNY 6,208.00
CNY 8,840.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | ARVD11; CDHF2; DG2; DGII/III; DSC3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC222207 representing NM_004949
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGA TCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAA ACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGAC TTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTT TTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAAC AAAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATT CCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACACGG CCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTA TGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAG ATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAG AGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAG AGTGGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTG AAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGA TCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGA CATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGAC CACTTGCCAACATTTACTCGTACTTCTTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCT TACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAA GGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTT AAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTT CCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGA GGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGC AATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATC CAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGC AGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACG GGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCA TCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACC CTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGAT ACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAG ATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTG CACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATA TTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAAC AACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGA TGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGC ACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCT CGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGA CAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGAATCCATTAGA GGACACACTCTGATTAAAAAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC222207 representing NM_004949
Red=Cloning site Green=Tags(s) MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPD FQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPI PCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFE IIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRL KYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVND HLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVV KPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTS NGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCT GTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAIND TAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAI LLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCG TVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIR GHTLIKN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_004949 |
| ORF Size | 2541 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004949.5 |
| RefSeq Size | 5186 bp |
| RefSeq ORF | 2544 bp |
| Locus ID | 1824 |
| UniProt ID | Q02487 |
| Domains | CA |
| Protein Families | Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| MW | 93.77 kDa |
| Gene Summary | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222207L3 | Lenti ORF clone of Human desmocollin 2 (DSC2), transcript variant Dsc2b, Myc-DDK-tagged |
CNY 10,740.00 |
|
| RC222207L4 | Lenti ORF clone of Human desmocollin 2 (DSC2), transcript variant Dsc2b, mGFP tagged |
CNY 10,740.00 |
|
| RG222207 | DSC2 (tGFP-tagged) - Human desmocollin 2 (DSC2), transcript variant Dsc2b |
CNY 9,690.00 |
|
| SC112671 | DSC2 (untagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2b |
CNY 6,208.00 |
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