CENPE (NM_001286734) Human Tagged ORF Clone

Specifications

Product Data
Type	Human Tagged ORF Clone
Tag	Myc-DDK
Synonyms	CENP-E; KIF10; MCPH13; PPP1R61
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >RC240253 representing NM_001286734 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTG GAGAAACTGCCCAAGTTTACTGGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTT CAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAAAATGTGTATGAAGAAATAGCAGCACCAATC ATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCAGGAAAAACAT ATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAAT TAAGAAGTTTCCTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACA GATTTACTCTGTGGCACTCAAAAAATGAAACCTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATG TTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAATGGATTACAAAGGGAGAAAA GAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATT TTGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGAATTTGG TTGATCTTGCAGGCAGTGAAAGAGCTGCTCAAACAGGCGCTGCAGGTGTGCGGCTCAAGGAAGGCTGTAA TATAAATCGAAGCTTATTTATTTTGGGACAAGTGATCAAGAAACTTAGTGATGGACAAGTTGGTGGTTTC ATAAATTATCGAGATAGCAAGTTAACACGAATTCTCCAGAATTCCTTGGGAGGAAATGCAAAGACACGTA TTATCTGCACAATTACTCCAGTATCTTTTGATGAAACACTTACTGCTCTCCAGTTTGCCAGTACTGCTAA ATATATGAAGAATACTCCTTATGTTAATGAGGTATCAACTGATGAAGCTCTCCTGAAAAGGTATAGAAAA GAAATAATGGATCTTAAAAAACAATTAGAGGAGGTTTCTTTAGAGACGCGGGCTCAGGCAATGGAAAAAG ACCAATTGGCCCAACTTTTGGAAGAAAAAGATTTGCTTCAGAAAGTACAGAATGAGAAAATTGAAAACTT AACACGGATGCTGGTGACCTCTTCTTCCCTCACGTTGCAACAGGAATTAAAGGCTAAAAGAAAACGAAGA GTTACTTGGTGCCTTGGCAAAATTAACAAAATGAAGAACTCAAACTATGCAGATCAATTTAATATACCAA CAAATATAACAACAAAAACACATAAGCTTTCTATAAATTTATTACGAGAAATTGATGAATCTGTCTGTTC AGAGTCTGATGTTTTCAGTAACACTCTTGATACATTAAGTGAGATAGAATGGAATCCAGCAACAAAGCTA CTAAATCAGGAGAATATAGAAAGTGAGTTGAACTCACTTCGTGCTGACTATGATAATCTGGTATTAGACT ATGAACAACTACGAACAGAAAAAGAAGAAATGGAATTGAAATTAAAAGAAAAGAATGATTTGGATGAATT TGAGGCTCTAGAAAGAAAAACTAAAAAAGATCAAGAGAATGAACTCAGTTCAAAAGTAGAGCTGCTTAGA GAAAAGGAAGACCAGATTAAGAAGCTACAGGAATACATAGACTCTCAAAAGCTAGAAAATATAAAAATGG ACTTGTCATACTCATTGGAAAGCATTGAAGACCCAAAACAAATGAAGCAGACTCTGTTTGATGCTGAAAC TGTAGCCCTTGATGCCAAGAGAGAATCAGCCTTTCTTAGAAGTGAAAATCTGGAGCTGAAGGAGAAAATG AAAGAACTTGCAACTACATACAAGCAAATGGAAAATGATATTCAGTTATATCAAAGCCAGTTGGAGGCAA AAAAGAAAATGCAAGTTGATCTGGAGAAAGAATTACAATCTGCTTTTAATGAGATAACAAAACTCACCTC CCTTATAGATGGCAAAGTTCCAAAAGATTTGCTCTGTAATTTGGAATTGGAAGGAAAGATTACTGATCTT CAGAAAGAACTAAATAAAGAAGTTGAAGAAAATGAAGCTTTGCGGGAAGAAGTCATTTTGCTTTCAGAAT TGAAATCTTTACCTTCTGAAGTAGAAAGGCTGAGGAAAGAGATACAAGACAAATCTGAAGAGCTCCATAT AATAACATCAGAAAAAGATAAATTGTTTTCTGAAGTAGTTCATAAGGAGAGTAGAGTTCAAGGTTTACTT GAAGAAATTGGGAAAACAAAAGATGACCTAGCAACTACACAGTCGAATTATAAAAGCACTGATCAAGAAT TCCAAAATTTCAAAACCCTTCATATGGACTTTGAGCAAAAGTATAAGATGGTCCTTGAGGAGAATGAGAG AATGAATCAGGAAATAGTTAATCTCTCTAAAGAAGCCCAAAAATTTGATTCGAGTTTGGGTGCTTTGAAG ACCGAGCTTTCTTACAAGACCCAAGAACTTCAGGAGAAAACACGTGAGGTTCAAGAAAGACTAAATGAGA TGGAACAGCTGAAGGAACAATTAGAAAATAGAGATTCTACGCTGCAAACTGTAGAAAGGGAGAAAACACT GATTACTGAGAAACTGCAGCAAACTTTAGAAGAAGTAAAAACTTTAACTCAAGAAAAAGATGATCTAAAA CAACTCCAAGAAAGCTTGCAAATTGAGAGGGACCAACTCAAAAGTGATATTCACGATACTGTTAACATGA ATATAGATACTCAAGAACAATTACGAAATGCTCTTGAGTCTCTGAAACAACATCAAGAAACAATTAATAC ACTAAAATCGAAAATTTCTGAGGAAGTTTCCAGGAATTTGCATATGGAGGAAAATACAGGAGAAACTAAA GATGAATTTCAGCAAAAGATGGTTGGCATAGATAAAAAACAGGATTTGGAAGCTAAAAATACCCAAACAC TAACTGCAGATGTTAAGGATAATGAGATAATTGAGCAACAAAGGAAGATATTTTCTTTAATACAGGAGAA AAATGAACTCCAACAAATGTTAGAGAGTGTTATAGCAGAAAAGGAACAATTGAAGACTGACCTAAAGGAA AATATTGAAATGACCATTGAAAACCAGGAAGAATTAAGACTTCTTGGGGATGAACTTAAAAAGCAACAAG AGATAGTTGCACAAGAAAAGAACCATGCCATAAAGAAAGAAGGAGAGCTTTCTAGGACCTGTGACAGACT GGCAGAAGTTGAAGAAAAACTAAAGGAAAAGAGCCAGCAACTCCAAGAAAAACAGCAACAACTTCTTAAT GTACAAGAAGAGATGAGTGAGATGCAGAAAAAGATTAATGAAATAGAGAATTTAAAGAATGAATTAAAGA ACAAAGAATTGACATTGGAACATATGGAAACAGAGAGGCTTGAGTTGGCTCAGAAACTTAATGAAAATTA TGAGGAAGTGAAATCTATAACCAAAGAAAGAAAAGTTCTAAAGGAATTACAGAAGTCATTTGAAACAGAG AGAGACCACCTTAGAGGATATATAAGAGAAATTGAAGCTACAGGCCTACAAACCAAAGAAGAACTAAAAA TTGCTCATATTCACCTAAAAGAACACCAAGAAACTATTGATGAACTAAGAAGAAGCGTATCTGAGAAGAC AGCTCAAATAATAAATACTCAGGACTTAGAAAAATCCCATACCAAATTACAAGAAGAGATCCCAGTGCTT CATGAGGAACAAGAGTTACTGCCTAATGTGAAAGAAGTCAGTGAGACTCAGGAAACAATGAATGAACTGG AGTTATTAACAGAACAGTCCACAACCAAGGACTCAACAACACTGGCAAGAATAGAAATGGAAAGGCTCAG GTTGAATGAAAAATTTCAAGAAAGTCAGGAAGAGATAAAATCTCTAACCAAGGAAAGAGACAACCTTAAA ACGATAAAAGAAGCCCTTGAAGTTAAACATGACCAGCTGAAAGAACATATTAGAGAAACTTTGGCTAAAA TCCAGGAGTCTCAAAGCAAACAAGAACAGTCCTTAAATATGAAAGAAAAAGACAATGAAACTACCAAAAT CGTGAGTGAGATGGAGCAATTCAAACCCAAAGATTCAGCACTACTAAGGATAGAAATAGAAATGCTCGGA TTGTCCAAAAGACTTCAAGAAAGTCATGATGAAATGAAATCTGTAGCTAAGGAGAAAGATGACCTACAGA GGCTGCAAGAAGTTCTTCAATCTGAAAGTGACCAGCTCAAAGAAAACATAAAAGAAATTGTAGCTAAACA CCTGGAAACTGAAGAGGAACTTAAAGTTGCTCATTGTTGCCTGAAAGAACAAGAGGAAACTATTAATGAG TTAAGAGTGAATCTTTCAGAGAAGGAAACTGAAATATCAACCATTCAAAAGCAGTTAGAAGCAATCAATG ATAAATTACAGAACAAGATCCAAGAGATTTATGAGAAAGAGGAACAATTTAATATAAAACAAATTAGTGA GGTTCAGGAAAAAGTGAATGAACTGAAACAATTCAAGGAGCATCGCAAAGCCAAGGATTCAGCACTACAA AGTATAGAAAGTAAGATGCTCGAGTTGACCAACAGACTTCAAGAAAGTCAAGAAGAAATACAAATTATGA TTAAGGAAAAAGAGGAAATGAAAAGAGTACAGGAGGCCCTTCAGATAGAGAGAGACCAACTGAAAGAAAA CACTAAAGAAATTGTAGCTAAAATGAAAGAATCTCAAGAAAAAGAATATCAGTTTCTTAAGATGACAGCT GTCAATGAGACTCAGGAGAAAATGTGTGAAATAGAACACTTGAAGGAGCAATTTGAGACCCAGAAGTTAA ACCTGGAAAACATAGAAACGGAGAATATAAGGTTGACTCAGATACTACATGAAAACCTTGAAGAAATGAG ATCTGTAACAAAAGAAAGAGATGACCTTAGGAGTGTGGAGGAGACTCTCAAAGTAGAGAGAGACCAGCTC AAGGAAAACCTTAGAGAAACTATAACTAGAGACCTAGAAAAACAAGAGGAGCTAAAAATTGTTCACATGC ATCTGAAGGAGCACCAAGAAACTATTGATAAACTAAGAGGGATTGTTTCAGAGAAAACAAATGAAATATC AAATATGCAAAAGGACTTAGAACACTCAAATGATGCCTTAAAAGCACAGGATCTGAAAATACAAGAGGAA CTAAGAATTGCTCACATGCATCTGAAAGAGCAGCAGGAAACTATTGACAAACTCAGAGGAATTGTTTCTG AGAAGACAGATAAACTATCAAATATGCAAAAAGATTTAGAAAATTCAAATGCTAAATTACAAGAAAAGAT TCAAGAACTTAAGGCAAATGAACATCAACTTATTACGTTAAAAAAAGATGTCAATGAGACACAGAAAAAA GTGTCTGAAATGGAGCAACTAAAGAAACAAATAAAAGACCAAAGCTTAACTCTGAGTAAATTAGAAATAG AGAATTTAAATTTGGCTCAGAAACTTCATGAAAACCTTGAAGAAATGAAATCTGTAATGAAAGAAAGAGA TAATCTAAGAAGAGTAGAGGAGACACTCAAACTGGAGAGAGACCAACTCAAGGAAAGCCTGCAAGAAACC AAAGCTAGAGATCTGGAAATACAACAGGAACTAAAAACTGCTCGTATGCTATCAAAAGAACACAAAGAAA CTGTTGATAAACTTAGAGAAAAAATTTCAGAAAAGACAATTCAAATTTCAGACATTCAAAAGGATTTAGA TAAATCAAAAGATGAATTACAGAAAAAGCAGGACCGACAGAACCACCAAGTAAAACCTGAAAAAAGGTTA CTAAGTGATGGACAACAGCACCTTACGGAAAGCCTGAGAGAAAAGTGCTCTAGAATAAAAGAGCTTTTGA AGAGATACTCAGAGATGGATGATCATTATGAGTGCTTGAATAGATTGTCTCTTGACTTGGAGAAGGAAAT TGAATTCCAAAAAGAGCTTTCAATGAGAGTTAAAGCAAACCTCTCACTTCCCTATTTACAAACCAAACAC ATTGAAAAACTTTTTACTGCAAACCAGAGATGCTCCATGGAATTCCACAGAATCATGAAGAAACTGAAGT ATGTGTTAAGCTATGTTACAAAAATAAAAGAAGAACAACATGAATCCATCAATAAATTTGAAATGGATTT TATTGATGAAGTGGAAAAGCAAAAGGAATTGCTAATTAAAATACAGCACCTTCAACAAGATTGTGATGTA CCATCCAGAGAATTAAGGGATCTCAAATTGAACCAGAATATGGATCTACATATTGAGGAAATTCTCAAAG ATTTCTCAGAAAGTGAGTTCCCTAGCATAAAGACTGAATTTCAACAAGTACTAAGTAATAGGAAAGAAAT GACACAGTTTTTGGAAGAGTGGTTAAATACTCGTTTTGATATAGAAAAGCTTAAAAATGGCATCCAGAAA GAAAATGATAGGATTTGTCAAGTGAATAACTTCTTTAATAACAGAATAATTGCCATAATGAATGAATCAA CAGAGTTTGAGGAAAGAAGTGCTACCATATCCAAAGAGTGGGAACAGGACCTGAAATCACTGAAAGAGAA AAATGAAAAACTATTTAAAAACTACCAAACATTGAAGACTTCCTTGGCATCTGGTGCCCAGGTTAATCCT ACCACACAAGACAATAAGAATCCTCATGTTACATCAAGAGCTACACAGTTAACCACAGAGAAAATTCGAG AGCTGGAAAATTCACTGCATGAAGCTAAAGAAAGTGCTATGCATAAGGAAAGCAAGATTATAAAGATGCA GAAAGAACTTGAGGTGACTAATGACATAATAGCAAAACTTCAAGCCAAAGTTCATGAATCAAATAAATGC CTTGAAAAAACAAAAGAGACAATTCAAGTACTTCAGGACAAAGTTGCTTTAGGAGCTAAGCCATATAAAG AAGAAATTGAAGATCTCAAAATGAAGCTTGTGAAAATAGACCTAGAGAAAATGAAAAATGCCAAAGAATT TGAAAAGGAAATCAGTGCTACAAAAGCCACTGTAGAATATCAAAAGGAAGTTATAAGGCTATTGAGAGAA AATCTCAGAAGAAGTCAACAGGCCCAAGATACCTCAGTGATATCAGAACATACTGATCCTCAGCCTTCAA ATAAACCCTTAACTTGTGGAGGTGGCAGCGGCATTGTACAAAACACAAAAGCTCTTATTTTGAAAAGTGA ACATATAAGGCTAGAAAAAGAAATTTCTAAGTTAAAGCAGCAAAATGAACAGCTAATAAAACAAAAGAAT GAATTGTTAAGCAATAATCAGCATCTTTCCAATGAGGTCAAAACTTGGAAGGAAAGAACCCTTAAAAGAG AGGCTCACAAACAAGTAACTTGTGAGAATTCTCCAAAGTCTCCTAAAGTGACTGGAACAGCTTCTAAAAA GAAACAAATTACACCCTCTCAATGCAAGGAACGGAATTTACAAGATCCTGTGCCAAAGGAATCACCAAAA TCTTGTTTTTTTGATAGCCGATCAAAGTCTTTACCATCACCTCATCCAGTTCGCTATTTTGATAACTCAA GTTTAGGCCTTTGTCCAGAGGTGCAAAATGCAGGAGCAGAGAGTGTGGATTCTCAGCCAGGTCCTTGGCA CGCCTCCTCAGGCAAGGATGTGCCTGAGTGCAAAACTCAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >RC240253 representing NM_001286734 Red=Cloning site Green=Tags(s) MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETIT DLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMI LESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGF INYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRK EIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKL LNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQENELSSKVELLR EKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKM KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLK QLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRL LSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKH IEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK ENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC LEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKN ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPK SCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001286734
ORF Size	7740 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001286734.2
RefSeq Size	8267 bp
RefSeq ORF	7743 bp
Locus ID	1062
UniProt ID	Q02224
Protein Families	Druggable Genome, Stem cell - Pluripotency
MW	302.2 kDa
Gene Summary	Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

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