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ATPSCKMT (NM_001258389) Human Tagged ORF Clone
CAT＃: RG236154
- TrueORF®
FAM173B (tGFP-tagged) - Human family with sequence similarity 173, member B (FAM173B), transcript variant 3
ORF Plasmid: DDK
"NM_001258389" in other vectors (2)
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CNY 4,370.00
Product images
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | FAM173B; hFAM173B; JS-2 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG236154 representing NM_001258389.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAGGGAGGAGGAGGTATACCCCTAGAAACACTTAAAGAAGAAAGTCAGTCAAGACATGTTCTACCT GCAAGTTTTGAAGTCAACAGTTTGCAGAAAAGCAACTGGGGGTTCTTACTTACTGGGCTTGTGGGTGGC ACCCTGGTGGCTGTGTACGCTGTAGCCACGCCGTTTGTAACGCCAGCCCTTCGAAAAGTCTGTTTGCCG TTTGTACCTGCAACTACGAAGCAGATTGAAAATGTTGTGAAAATGTTGCGATGCCGAAGAGGATCCCTT GTGGACATCGGTAGTGGGGACGGACGCATTGTCATAGCGGCTGCGAAGAAAGGGTTCACAGCAGTTGGT TATGAATTAAACCCATGGCTAGTTTGGTATTCCAGATACCGCGCTTGGCGAGAAGGTTACTTTTTCGCA GTACTCGAACGTTGTTATTTTCGGTGTGCCTCAGATGATGCTGCAGTTGGAGAAGAAACT ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG236154
Blue=ORF Red=Cloning site Green=Tag(s) MEGGGGIPLETLKEESQSRHVLPASFEVNSLQKSNWGFLLTGLVGGTLVAVYAVATPFVTPALRKVCLP FVPATTKQIENVVKMLRCRRGSLVDIGSGDGRIVIAAAKKGFTAVGYELNPWLVWYSRYRAWREGYFFA VLERCYFRCASDDAAVGEET TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001258389 |
| ORF Size | 474 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001258389.1, NP_001245318.1 |
| RefSeq Size | 2628 bp |
| RefSeq ORF | 477 bp |
| Locus ID | 134145 |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 17.8 kDa |
| Gene Summary | Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090).[UniProtKB/Swiss-Prot Function] |
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