Mrc2 (NM_001024687) Rat Untagged Clone

Specifications

Product Data
Type	Rat Untagged Clone
Tag	Tag Free
Synonyms	Endo180
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >RN215359 representing NM_001024687 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGACCCATCCGACCTGCCCTGGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGTCTTACTTCTCGGGG GACTTCGTCTTGGCCACCCGGCAGACTCCGCCGCCGCCCTCCTGGAACCCGATGTCTTCCTCATCTTCAG CCAGGGGATGCAGGGCTGCCTGGAGGCCCAGGGTGTGCAGGTCCGAGTCATCCCAGTCTGCAATGCCAGT CTCCCTGCCCAGCGCTGGAAGTGGGTCTCCCGGAACCGACTCTTCAACCTGGGGGCCATGCAGTGCCTGG GTACCGGCTGGCCTGCCACCAACACCACAGTTTCCCTGGGCATGTATGAATGTGACCGAGAGGCCTTGAG TCTTCGCTGGCAGTGTCGTACACTAGGGGACCAGTTGTCTCTGCTTCTGGGGGCCCGTGCAAACAATGCA TCGAAGCCTGGTACCCTGGAGCGCGGCGACCAGACCCGCAGTGGCCATTGGAACATCTATGGCAGTGAAG AAGACCTATGTGCTCGACCCTACTACGAGGTCTACACCATCCAGGGAAACTCCCACGGGAAGCCGTGTAC TATCCCCTTCAAATACGACAACCAGTGGTTCCACGGCTGCACCAGCACGGGCCGGGAAGATGGGCACCTG TGGTGTGCCACCACCCAGGACTACGGCAAAGACGAGCGCTGGGGCTTCTGCCCCATCAAGAGTAACGACT GTGAGACATTCTGGGACAAAGACCAGCTGACTGACAGCTGTTACCAGTTTAACTTCCAATCCACACTGTC CTGGAGGGAGGCCTGGGCCAGCTGCGAGCAGCAGGGTGCAGACCTGTTGAGCATCACGGAGATCCACGAG CAGACCTACATCAATGGACTCCTCACGGGCTACAGCTCCACGCTGTGGATTGGCCTTAATGACTTGGACA CCAGTGGAGGCTGGCAGTGGTCTGACAACTCGCCCCTCAAGTACCTCAACTGGGAGAGTGATCAGCCGGA CAACCCAGGTGAGGAGAACTGTGGAGTGATCCGGACCGAGTCCTCAGGTGGCTGGCAGAACCATGACTGC AGCATCGCCCTGCCCTATGTCTGCAAGAAAAAACCCAACGCCACAGCCGAGCCCATCCAGCCAGACAGGT GGGCCAATGTCAAGGTGGAGTGTGACCCCAGCTGGCAGCCCTTCCAGGGCCACTGCTACCGCCTGCAGGC GGAGAAGCGCAGCTGGCAGGAGTCCAAGAGGGCGTGCCTACGGGGCGGGGGCGACCTCCTTAGCATCCAC AGCATGACTGAGCTGGAGTTCATCACCAAACAGATCAAGCAAGAGGTGGAAGAGCTATGGATTGGCCTCA ATGATTTGAAGCTGCAGATGAATTTTGAGTGGTCTGATGGGAGCCTCGTGAGTTTCACCCACTGGCACCC CTTTGAGCCCAACAACTTCCGTGACAGCCTGGAAGACTGTGTCACCATCTGGGGGCCGGAAGGACGCTGG AATGACAGTCCCTGTAACCAATCCTTGCCCTCCATCTGCAAGAAGGCAGGCCGACTGAGCCAGGGCACTG CAGAGGAGGACCATGGCTGCCGGAAGGGTTGGACATGGCATAGCCCATCCTGCTACTGGCTGGGAGAGGA CCAAGTGATCTACAGTGATGCCCGGCGTCTGTGTACTGACCATGGCTCTCAGCTGGTCACCATCACCAAC AGGTTTGAGCAGGCCTTCGTCAGCAGCCTCATCTATAACTGGGAGGGCGAGTACTTCTGGACGGCCCTCC AAGACCTCAACAGCACCGGCTCCTTCCGTTGGCTCAGTGGGGATGAAGTCATGTATACCCATTGGAACCG AGACCAGCCTGGGTACAGACGTGGGGGCTGTGTGGCTCTGGCCACGGGCAGTGCCATGGGACTGTGGGAG GTGAAGAACTGCACGTCGTTCCGGGCTCGCTACATCTGCCGACAGAGCCTGGGCACACCAGTGACACCAG AGTTGCCTGGCCCAGACCCCACACCCAGCCTCACTGGCTCCTGTCCCCAGGGCTGGGTCTCAGACCCCAA ACTCCGACACTGCTATAAGGTGTTTAGCTCAGAGCGGCTGCAGGAGAAGAAGAGTTGGATCGAGGCCCTC GGGGTTTGCCGGGAGTTGGGGGCCCAGCTGCTGAGTCTGGCCAGCTATGAGGAGGAACATTTTGTGGCCA ACATGCTCAACAAGATCTTTGGTGAGTCAGAACCTGAGAACCATGAGCAGCACTGGTTTTGGATTGGCCT GAACCGCAGAGACCCTAGAGAGGGTCACAGCTGGCGCTGGAGCGACGGTCTAGGGTTTTCCTACCACAAT TTTGCCCGGAGCCAGCACGATGACGACAATATCCGAGGCTGTGCGGTGCTGGACCTGGCCTCCCTGCAGT GGGTAGCCATGCAGTGCCAGACACAACTTGACTGGATCTGCAAGATCCCTAGAGGTGTGGATGTGCGGGA ACCAGACATTGGTCGGCAAGGCCGTCTGGAGTGGGTACGCTTTCAGGAGGCGGAGTACAAGTTTTTTGAG CACCACTCCTCGTGGGCGCAGGCACAGCGCATCTGTACGTGGTTCCAGGCAGAGCTGACCTCTGTTCACA GCCAGGCAGAACTGGACTTCCTGGGGCAAAATATGCAGAAGTTGTCCTCAGACCAGGAGCAGCACTGGTG GATCGGCCTGCACACCTCAGAGAGCGACGGACGCTTCAGGTGGTCAGATGGTTCTGTTATAAACTTTGTC TCCTGGGCACCGGGAAAACCTCGACCCATTGGCAAGGACAAGAAGTGTGTGTACATGACAGCTAGACAAG AGGACTGGGGGGACCAGAGGTGCCATACAGCCTTGCCCTACATCTGTAAACGCAGCAATAGCTCTGGAGA GACTCGGCCTCACGACCTGCCACCGTCAACCCTAGGAGGCTGCCCCTCCGGCTGGAACCAGTTCCTCAAC AAGTGTTTCCGAATCCAGGGCCAGGACCCCCAGGACAGGGTGAAATGGTCAGAGGCACAGTTCTCCTGTG AACAGCAAGAAGCCCAGCTGGTCACCATTGCAAACCCCTTAGAGCAAGCGTACATCACGGCCAGCCTCCC CAATGTGACCTTTGACCTCTGGATTGGCCTGCATGGCTCTCAGAGGGACTTCCAGTGGATTGAGCAGGAA CCTCTGCTCTATACCAATTGGGCACCAGGAGAGCCCTCTGGACCCAGCCCTGCTCCCAGTGGCACCAAGC CGACCAGCTGTGCGGTGATTCTGCACAGCCCCTCAGCCCACTTCACTGGCCGCTGGGATGATCGGAGCTG CACAGAGGAGACGCACGGCTTCATCTGCCAGAAGGGCACAGACCCCTCGCTGAGCCCATCCCCGGCAGCA GCACTCCCTGCCCCAGGCACCGAGCTCTCCTACCTCAACCGCACCTTCCGGCTGCTGCAGAAGCCACTGC GCTGGAAAGATGCTCTCCTGCTGTGTGAGAGCCGGAATGCCAGCCTGGCACACGTGCCTGATCCCTACAC CCAGGCCTTCCTTACGCAGGCTGCCCGGGGGCTGCAAGCACCACTGTGGATCGGGCTGGCCAGTGAGGAG GGCTCAAGGCGGTATTCCTGGCTCTCGGAGGAGCCTCTGAATTATGCGAGCTGGCAAGACGGGGAGCCCC AGCACACAGGGGGCTGTGCCTATGTGGATGTGGATGGAACCTGGCGCACCACCAGCTGTGACACCAAGCT GCAGGGGGCAGTGTGTGGGGTGAGCAGAGGGCCCCCTCCTCCAAGGATAAGCTACCGCGGCAGCTGTCCT CAGGGCCTGGCTGACTCGTCCTGGATTCCCTTCAGGGAGCACTGCTACTCTTTCCACACGGAGCTGCTGC TGGGCCACAAGGAGGCACTGCAGCGCTGCCAAAGAGCTGGTGGGACAGTTCTGTCCATTCTTGATGAGAT GGAGAATGTGTTTGTCTGGGAGCACCTGCAGACCGCTGAAACCCAGAGTCGGGGTGCCTGGTTGGGCATG AACTTCAATCCCAAAGGAGGCATGCTGGTCTGGCAAGACAATACAGCTGTGAACTATTCTAACTGGGGCC CCCCTGGCCTGGGCCCTAGCATGCTAAGCCACAACAGCTGCTACTGGATCCAGAGCAGCAGCGGGCTGTG GCGCCCCGGTGCTTGTACCAACGTCACCATGGGAGTTGTCTGCAAGCTCCCTAGAGTGGAGGAGAACGGC TTCCTGCCATCAGCAGCGCTTCCTGAGAACCCGGTGGCCCTGGTGGTGGTGCTGACTGCGGCAGTCCTAC TCCTCCTGGCCTTGCTGACAGGGGCCCTCATCCTCTACCGGCGCCGACAGAGTGCGGAGCGTGGGTCTTT TGAGGGGGCTCGCTACAGTCGCAGCAGCCGCTCTGGCCCGGCAGAGGCCACCGAGAAGAACATCCTGGTT TCTGACATGGAAATGAACGAACAACAAGAATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001024687
Insert Size	4443 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001024687.1, NP_001019858.1
RefSeq Size	4443 bp
RefSeq ORF	4443 bp
Locus ID	498011
UniProt ID	Q4TU93
Gene Summary	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs.[UniProtKB/Swiss-Prot Function]

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