Kank2 (NM_001270413) Rat Untagged Clone

Specifications

Product Data
Type	Rat Untagged Clone
Tag	Tag Free
Synonyms	RGD1563532
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >RN217253 representing NM_001270413 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCCCAGGTCCTGCATGTGCCCGCCCCATTCCCAGGAACCCCTGGCCAAGCCTCCTCAGCGGCCTTCC CCAACAAGGAGCCAGACCCGCCATACTCGGTGGAGACGCCCTATGGCTACCGCCTGGACCTGGACTTTCT TAAGTACGTGGATGACATTGAGAAGGGCCACACACTGCGCAGGGTGCCGGTGCAGCGCCGGCCACGCCTG GGCTCCCTGCCACGTGGCCCGGGCTCCTGGTGGACGTCCACAGAGTCGCTGTGCTCTGACGCCAGTGGGG ACAGCCGGCACTCGGCCTACTCCTACTGTGGCCGCGGCTTCTACCCACAGTACGGAGCCTTGGAGACCCG CAGCGGCACCAACCCACGCGTGGAACGCACGCTGCTGGATGCGCGGCGCCGACTGGAGGACCAGGCGGCT GCCCCATCATCGGGTGGCCTGGGCTCTCTGACGCCCAGCGCTGCGGGCTCCACCAGCTCCCTGGCAGGCG TGGGCCTGCTGCCCCCCACACCTCGCAGCTCTGGCTTGTCCACCCCAGTGGCACCCAGCGCTGGTCACCT GGCCCACGTGCGCGAACAGATGGCTGGAGCCCTGCGCAAGCTGCGCCAGCTGGAGGAGCAGGTCAAGCTG ATCCCCGTGCTCCAGGTCAAGCTGTCGGTGCTCCAGGAGGAAAAAAGACAGCTCACCGTGCAGCTCAAGA GCCAGAAGTTTCTAGGCCACCCCTCAGGGACAAGGAGCCGGAGCGAGCTCTGCCTGGACCTTCCGGAGGC CCCCGACGACCCTGCTGTGCTAGAGACTCGCTCGGTGGGCACCTGGGTTCGAGAAAGGGATTTGGGCATT CCAGATGGTGAAGCTGCCCTGGTAGCTAAAGTGGCCGTGTTGGAGACCCAGCTCAAAAAAGCGCTGCAGG AGCTGCGGGCGGCTCAGACCCAGCAGGTCGACCTCCAGCCCCAAGCCTGGCCACCACCAGACACCCAGGT CCGCGTGGACACCGTGCGAGTTGTGGAGGGTCCCCGGGAAGTGGAGGTGGCAGCCAGCACGGCAGCCGGG GCTCCTGCACAGCGAGCTCAGAGTCTGGAACCCTATGGAGCAGGGCTGAAGGCCCTGGCCACATCTGCGG AGAACACCCTTGTGTTCCGAAGTCATGAGGTGGTGGAGACCATGTGTCCCCTGCCCACAGCTTCCACCAG CAACATGCACACAGCCAAGAAGATCAGTATTACAGAACGGAATTGCACTGGTGCGGCCAGGATGGCAGAG CCTTCCCCCTCTAGTCCATACCCTGCTGCAGAGCCTGAGAACCCTGCCCCAGCTGCCCAGGACACCACGG ACAGGGAGCTCACCAGGCCTGTGGCATCGCAGGACTCACAAGCGGCCGAGGGAGCAGGCGGAGCCTCCTT GGGAGTCCAATCAGCCTTGAAGAGGAAAGAGGTCCCTGCAGACCCTGACGTCCACCAGAGGAACCTTCAG TTTGTGGGCATCAATGGCGGGTATGAGTCCTCCTCGGAAGACTCCAGCACAGCAGAGAACTCGGAACACG AGAGCACAGAGAACGAGGCCCCAGAGCCTCCGGTGAGGGTTCTGAGCACAGCTGAAGGCCCTCAGCTCAG GCCTCTGGGGCCTGCAGTGGGCAAGACCAGTCAGGACGAGCGTCAGCTCTCTCAGGAATCCCAGCGTGTG CCCGAAGCCAAGGTGGCCCCAGGACCTGACCCCGAGGAGGAGATTCGGATGGATCTGAGCCCTGACCTCA TATCAGCATGCTTGGCCCTGGAGAAATACTTGGAGAACCCCAATGCCCTCACGGAGCGAGAACTGAAAGT GGCTTATACCACGGTGCTTCAGGAGTGGCTGCGCCTGGCCTGCCGCAGTGATGCACACCCTGAGCTTGTA CGGCGACATCTGGTCACCTTCAGGGCCATGTCTGCCCGGCTGCTGGACTATGTGGTCAACATCGCTGACA GCAATGGTAACACTGCCCTGCACTACTCCGTGTCACATGCCAACTTCCCTGTGGTTCGGCAGTTGCTGGA CAGCGGCGTGTGTCAGGTGGACAAGCTAAACCGTGCTGGCTACAGCCCGATAATGCTCACTGCTTTGGCC ACCCTGAAGACCCAGGATGACATTGACACCATCCTTCAACTCTTCCGCCTTGGGAATGTCAACGCCAAAG CCAGCCAGGCAGGACAGACGGCCCTGATGCTGGCGGTCAGCCACGGGCGGGTGGATGTGGTGAAAGCGCT GTTGGCCTGTGAGGTGGATGTTAACATGCAGGATGAGGACGGCTCCACGGCCCTGATGTGTGCGTGTGAG CACGGACACAAGGAGATCACCGGGCTCCTGCTGGCTGTGCCTAGCTGTGACATCTCACTCACCGACCGCG ATGGAAGCACAGCGCTGATGGTAGCCCTCGACGCTGGGCAGAGCGAGATCGCATCTATGCTGTACTCACG CATGAACATCAAGTGCTCCTTCGCTCCCATGTCAGACTACGAGAGTCCGGCTTCGTCTTCAGCTGAAGAG TGA AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-RsrII
ACCN	NM_001270413
Insert Size	2523 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001270413.1, NP_001257342.1
RefSeq Size	4792 bp
RefSeq ORF	2523 bp
Locus ID	100361376
Gene Summary	Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).[UniProtKB/Swiss-Prot Function]

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