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SLFN11 (NM_152270) Human Untagged Clone
CAT＃: SC100556
SLFN11 (untagged)-Human schlafen family member 11 (SLFN11), transcript variant 5
CNY 6,608.00
货期*
现货
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SLFN8/9 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC100556 sequence for NM_152270 edited (data generated by NextGen Sequencing)
ATGGAGGCAAATCAGTGCCCCCTGGTTGTGGAACCATCTTACCCAGACCTGGTCATCAAT GTAGGAGAAGTGACTCTTGGAGAAGAAAACAGAAAAAAGCTGCAGAAAATTCAGAGAGAC CAAGAGAAGGAGAGAGTTATGCGGGCTGCATGTGCTTTATTAAACTCAGGAGGAGGAGTG ATTCGAATGGCCAAGAAGGTTGAGCATCCCGTGGAGATGGGACTGGATTTAGAACAGTCT TTGAGAGAGCTTATTCAGTCTTCAGATCTGCAGGCTTTCTTTGAGACCAAGCAACAAGGA AGGTGTTTTTACATTTTTGTTAAATCTTGGAGCAGTGGCCCTTTCCCTGAAGATCGCTCT GTCAAGCCCCGCCTTTGCAGCCTCAGTTCTTCATTATACCGTAGATCTGAGACCTCTGTG CGTTCCATGGACTCAAGAGAGGCATTCTGTTTCCTGAAGACCAAAAGGAAGCCAAAAATC TTGGAAGAAGGACCTTTTCACAAAATTCACAAGGGTGTATACCAAGAGCTCCCTAACTCG GATCCTGCTGACCCAAACTCGGATCCTGCTGACCTAATTTTCCAAAAAGACTATCTTGAA TATGGTGAAATCCTGCCTTTTCCTGAGTCTCAGTTAGTAGAGTTTAAACAGTTCTCTACA AAACACTTCCAAGAATATGTAAAAAGGACAATTCCAGAATACGTCCCTGCATTTGCAAAC ACTGGAGGAGGCTATCTTTTTATTGGAGTGGATGATAAGAGTAGGGAAGTCCTGGGATGT GCAAAAGAAAATGTTGACCCTGACTCTTTGAGAAGGAAAATAGAACAAGCCATATACAAA CTACCTTGTGTTCATTTTTGCCAACCCCAACGCCCGATAACCTTCACACTCAAAATTGTG GATGTGTTAAAAAGGGGAGAGCTCTATGGCTATGCTTGCATGATCAGAGTAAATCCCTTC TGCTGTGCAGTGTTCTCAGAAGCTCCCAATTCATGGATAGTGGAGGACAAGTACGTCTGC AGCCTGACAACCGAGAAATGGGTAGGCATGATGACAGACACAGATCCAGATCTTCTACAG TTGTCTGAAGATTTTGAATGTCAGCTGAGTCTATCTAGTGGGCCTCCCCTTAGCAGACCA GTGTACTCCAAGAAAGGCCTGGAACATAAAAAGGAACTCCAGCAACTTTTATTTTCAGTC CCACCAGGATATTTGCGATATACTCCAGAGTCACTCTGGAGGGACCTGATCTCAGAGCAC AGAGGACTAGAGGAGTTAATAAATAAGCAAATGCAACCTTTCTTTCGGGGAATTTTGATC TTCTCTAGAAGTTGGGCTGTGGACCTGAACTTGCAGGAGAAGCCAGGAGTCATCTGTGAT GCTCTGCTGATAGCACAGAACAGCACCCCCATTCTCTACACCATTCTCAGGGAGCAGGAT GCAGAGGGCCAGGACTACTGCACTCTCACTGCCTTTACTTTGAAGCAGAAGCTAGTGAAC ATGGGGGGCTACACCGGGAAGGTGTGTGTCAGGGCCAAGGTCCTCTGCCTGAGTCCTGAG AGCAGCGCAGAGGCCTTGGAGGCTGCAGTGTCTCCGATGGATTACCCTGCGTCCTATAGC CTTGCAGGCACCCAGCACATGGAAGCCCTGCTGCAGTCCCTCGTGATTGTCTTACTCGGC TTCAGGTCTCTCTTGAGTGACCAGCTCGGCTGTGAGGTTTTAAATCTGCTCACAGCCCAG CAGTATGAGATATTCTCCAGAAGCCTCCGCAAGAACAGAGAGTTGTTTGTCCACGGCTTA CCTGGCTCAGGGAAGACCATCATGGCCATGAAGATCATGGAGAAGATCAGGAATGTGTTT CACTGTGAGGCACACAGAATTCTCTACGTTTGTGAAAACCAGCCTCTGAGGAACTTTATC AGTGATAGAAATATCTGCCGAGCAGAGACCCGGAAAACTTTCCTAAGAGAAAACTTTGAA CACATTCAACACATCGTCATTGACGAAGCTCAGAATTTCCGTACTGAAGATGGGGACTGG TATGGGAAGGCAAAAAGCATCACTCGGAGAGCAAAGGGTGGCCCAGGAATTCTCTGGATC TTTCTGGATTACTTTCAGACCAGCCACTTGGATTGCAGTGGCCTCCCTCCTCTCTCAGAC CAATATCCAAGAGAAGAGCTCACCAGAATAGTTCGCAATGCAGATCCAATAGCCAAGTAC TTACAAAAAGAAATGCAAGTAATTAGAAGTAATCCTTCATTTAACATCCCCACTGGGTGC CTCGAGGTATTTCCTGAAGCCGAATGGTCCCAGGGTGTTCAGGGAACCTTACGAATTAAG AAATACTTGACTGTGGAGCAAATAATGACCTGTGTGGCAGACACGTGCAGGCGCTTCTTT GATAGGGGCTATTCTCCAAAGGATGTTGCTGTGCTTGTCAGCACCGCAAAAGAAGTGGAG CACTATAAGTATGAGCTCTTGAAAGCAATGAGGAAGAAAAGGGTGGTGCAGCTCAGTGAT GCATGTGATATGTTGGGTGATCACATTGTGTTGGACAGTGTTCGGCGATTCTCAGGCCTG GAAAGGAGCATAGTGTTTGGGATCCATCCAAGGACAGCTGACCCAGCTATCTTACCCAAT GTTCTGATCTGTCTGGCTTCCAGGGCAAAACAACACCTGTATATTTTTCCGTGGGGTGGC CATTAG Clone variation with respect to NM_152270.3 901 a=>g;1437 a=>g;1466 g=>t;1470 c=>t >OriGene 5' read for NM_152270 unedited
GGTCAACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACCAGCTTGAGAGGT CAGAGAGGGTCCTTGCCCCCGGCCTGGGACTCCGGAGTTGCGTTTCTACCCGTGCTTCAG GGTCTAGCCCAGCCGAATCCGCGTCGGGCTGTAACTCGAGTGCCAGTTTCAGCTGTGAGT TCAACATGGAGGCAAATCAGTGCCCCCTGGTTGTGGAACCATCTTACCCAGACCTGGTCA TCAATGTAGGAGAAGTGACTCTTGGAGAAGAAAACAGAAAAAAGCTGCAGAAAATTCAGA GAGACCAAGAGAAGGAGAGAGTTATGCGGGCTGCATGTGCTTTATTAAACTCAGGAGGAG GAGTGATTCGAATGGCCAAGAAGGTTGAGCATCCCGTGGAGATGGGACTGGATTTAGAAC AGTCTTTGAGAGAGCTTATTCAGTCTTCAGATCTGCAGGCTTTCTTTGAGACCAAGCAAC AAGGAAGGTGTTTTTACATTTTTGTTAAATCTTGGAGCAGTGGCCCTTTCCCTGAAGATC GCTCTGTCAAGCCCCGCCTTTGCAGCCTCAGTTCTTCATTATACCGTAGATCTGAGACCT CTGTGCGTTCCATGGACTCAAGAGAGGCATTCTGTTTCCTGAAGACCAAAAGGAAGCCAA AAATCTTGGAAGAAAGACCTTTTCACANAATTCACAAGGGTGTATACCAAGAGCTCCCTA ACTCGGATCCTGCTGNACCCAAACTCGATCCTGCTGACCTAATTTTCCAAAAAGACTATC TTTGATATGNGTGAAATCCCTGCCTTTNCTGAGTCTCAGNTAGTAGAGTTTAAACAGTTC TCTACAAACACTTNCAGAATAATGTAAAAGGACAATTCAGNATACGTNCCTGCATTTGCA ACACTGGNAGAGCTATCTTTTATTGGAGTGATGATAGAGTAGGGAAA >OriGene 3' read for NM_152270 unedited
NCCGGAATTACTAGGACCGCGCCGCATTCTANGATCGATTTTTTTTTTTTTTTTTTTTTC AGTTTAATGAGACACAAACTCTCAACTTTTTATTTAAAACAGAAATGCAGTAGTAAGCTA AACCTTTTGCCATTCATAGGGAAACAAATATCAGTAATCCTCTTTGTTCTAAACAAAAAT TCATAATTATTTATACATTTTATAATATTATATTGTTTCAAATGTTGTTAGTGGGGCAAT AAATCATAAAGAGATACAACCAGTCGAAATTAGACTTTTAAAGAATTACTCTCAAAGAAA TTGCAACAACTCCAAAGTCCAGGGATCTTATAAGACTAATTTATTATTAACAACATTTAC AAAGATAGCTTTTTAATGCTGAGTTGTATCTGATTTAATGCAGTCAGAAAGAAAAAAGAA ACATTTATCTCATTTTGCTGATCTGTCAGATTTTGCTTAAGTTAGGAGAGCCTGCAATTT CAAGCCCAGATAACTGGAATTCCATGAATAAACACAGAAAGACAGGAGAAAGGCAAGGAA GTTCAAAAATCACAGTCTGGGGGGAAATCAGTAGAGTAAGATTACCAATAAGTGAAATAT TGGTCATATGATTTCTTAATTTCCATTAGTTATGCAAATATTTTACTGTTAATATTTAAA TTAAGTGTTTTAGAACGTTTTGTAGCGACTGAAAAGCACATAAAAATGCCTTAACATTGT TAATATCAGTGTTTTCAGGTTGGACAATATTCTTCACCTGGGTTCCCGGCCTGCAATAAC ACACCCGCAAATATGGCGGCCTGAACCCCAGAATATTTTTCCAAAGAACGGAGGCGGGAA ATCCGACACAAGTTCCAACAACTTCCGAGCAGCAAAGGTTTCAATGGCGACCCCCCCCCA CGGCCTGAGGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_152270 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_152270.2, NP_689483.2 |
| RefSeq Size | 4915 bp |
| RefSeq ORF | 2706 bp |
| Locus ID | 91607 |
| UniProt ID | Q7Z7L1 |
| Domains | AAA_div |
| Gene Summary | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208638 | SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 5 |
CNY 3,990.00 |
|
| RC208638L3 | Lenti-ORF clone of SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 5 |
CNY 5,890.00 |
|
| RC208638L4 | Lenti-ORF clone of SLFN11 (mGFP-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 5 |
CNY 5,890.00 |
|
| RG208638 | SLFN11 (tGFP-tagged) - Human schlafen family member 11 (SLFN11), transcript variant 5 |
CNY 4,370.00 |
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