Peroxiredoxin 2 (PRDX2) (AK022395) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK022395, the custom clone sequence may differ by one or more nucleotides ACGTCTTGGTTCGGGCCGGGCATAAAAGGCTTCGCGGCCCAGGGCTCACTTGGCGCTGAGAACGCGGGTC CACGCGTGTGATCGTCCGTGCGTCTAGCCTTTGCCCACGCAGGTATGAACACCCGGAGTGCACCTGGCGG GAGGACCCCCTTCAGGCTGCTTTGGCCCGATCCTGACTTTAGTGCTGGCCGCCTTTGCTTTCCATCCGCT ATAGTGGCCTCCTTTGTCCTTGCGGGGGAAACCGAGGCCACAGCCTTGCAGCGCAGTCCTGATCGCCCGA CTTCCCGCCCCCTGCTCGTGCGGGCCTCACTGTCTCCTTCTGGGCTGGGGGCTTGCGACACCGCCCTCCG GCCGACTCGCTCGTGGGGTGCTGGTGGCAGTGGCTGGGTCACTCGTGCTCTGGTCAGGAGAGCGGGTCTC CGGCAGCCTCCGGGCCTCGTAGACCGGGTACCCGGGAGGGTGAGGGTTAGTGCTGTCGCCTCCGCCGTGC TGACTCAGTCATAGGGCCCAGCACGCAGCGCGACCTTGGGTTGGGAGGACAAAGTGTCTTCCCGGGCGCA CTGACCGGGCGGGGGTCTCAGCTTTCAGTCATGGCCTCCGGTAACGCGCGCATCGGAAAGCCAGCCCCTG ACTTCAAGGCCACAGCGGTGGTTGATGGCGCCTTCAAAGAGGTGAAGCTGTCGGACTACAAAGGTGAGCG CCGCCCGGAGGGGGCCCAGGTAGAAGCGGGGCCGTGCATGAGAGAAGCTGGGCCCTAACTCCTCTGTGTC CCTCCTCCCCAGGGAAGTACGTGGTCCTCTTTTTCTACCCTCTGGACTTCACTTTTGTGTGCCCCACCGA GATCATCGCGTTCAGCAACCGTGCAGAGGACTTCCGCAAGCTGGGCTGTGAAGTGCTGGGCGTCTCGGTG GACTCTCAGTTCACCCACCTGGCTTGGTATGAGCAGGGGCCAAAGAGGGAGGTTGCAGCTAAGCTCACAC CCTCAGGTCCTAGCAGTGTGGCTTCGTGGCCATTGCTCAACCTCTGGAACCTGCGTTTCCCCATCGTGAA AATAATGGAAACATTGCCGCCCAAGTCTTTAAGGATGATGACAGTAATTAGCATTTGACAACTAGTTGCC TGGTATATAGAGTTGCAGATGCAACTCAGATGCAACTCTATCTACTCTATGTACTTAGTTCCCAGGAGGG AGGCTGTGCTGCCCTATTTCATGAAGATGGAAACTCCAGTTCACCGAAGTGAAGGGCTGTACCCCATGAC ACAGCTAGAGGAGGATGGGGACTCTTAACACAGGCTCTCTGCTGGGTGATGCTGCAAGTTACAAGTACAT GTGAAGCCACTTAGCTGGAGCTGTGCCTCTCAAACTCAGTCTTCCCAGCCATGGGGATACAGTCCTTGCA CCCAACCCAGGGTGGGGTGGGTGAGGCTCCCAGCGGCCTACTCTAAAGCCCCTTATCTCCGGCCTCCAGT GCTTATCACATTGGGCCCACAGGGTGAGGACCCTGCTGTGCCAGGCATCCTGAGGCCCCAACTCTGTCTC CCCTACTCCCAGGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCCTGAACATCCCCCTGCTTGCT GACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAACAGATGAGGGCATTGCCTACAGGTACT GTGGGACCCTCAGCCCGGCTCAGGGAGCGCCCTGCCCCCCATTCCTGTGATGCTGGGACCACTCCTGTAC AATGTCTTCTCTGCCCCCAGCCCTGTGGCTAGCAGCGGGTGGTTGGTAGTCCCTTCCTTGTCTCTGGCAG TGGGAGCTATCAGCTCCTCACTGGGAACCCTGATGTCTTCAGGGGCCTCTTTATCATCGATGGCAAGGGT GTCCTTCGCCAGATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCC AGGCCTTCCAGTACACAGACGAGCATGGGGAAGGTGAGCAGATACACACATGACACATGGGTACATACTG AGCGCCTCCGTCACTCATGCAAACATTCACTGCCTGTCCTCTTACCTGTCCAGATGGGTGTTAGGGCCCC AAAGAAGATTCAGCTCAGGGCTTTGTCTGCAGGATGTTTCTAATGTGGTAGGAGACAAATAACGCCTGAC ATTCAACCAAGGTGGACAAAGGGGCCGGGCTCAGTGGCTCACGGTTGTATTGCCAGCACTTTGGGAAGCT GTGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTA CGAAGAACACAAAAAATTAGCTGGCCGTGGTGGTGCACACTTGTAATCCCAGCTACTTGAGAGACTGAGG CAGGAGTTCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCGTTGTACTCCAGCTTG GGCAACAGAGCAAAACTCAGTCTCAAAAAAAAAAAAAAATTAGCTTGGTTTGTGAAGCATGCCTATAGTC CCAGCTACTCAAGAGGCTGAGGCTGGAGGATCACTTGAGCCTGGGAGGTCAAGGCTGCAGTAAGCTGTGA TCGCACCACTGCACTCCAGCCTGGGTGACACAGCAAGACCCTGTCTCAAAAAAACAAACAAACAGGCCGA GCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGT TTGAGACCAGCCTGGCCAACATAGTGAAACCGCGTCTCTGCTAAAAATACAAAAAAATTAGCTGGGTGCG GTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGACTCCCTTGAACCCGGGAGGAGG TTGCAGTAAGCCGAGATCACACCACTGCACTCCAGCCTGGGCGCCAGTGTGAGACTCCATCCCAAAAACA ACAACAACAAAAAAACCTGTAGGGGTGGGGCAGAGGGACAAAGATGGGACTAAAGGAGCCAAAAAGACAG GAAGATGCTGTGTCTCATGCCTGTAGATGCTGTGTCTCATGCCTGTAGTTCCACCTACTCTGGAGAGTGA GGCAGAAGACTGCTTAGGCCCAGGAATTTGAGTCGAGCCTAGGCAACATAGCAATACCCCATCTCTTTTT TTTTTTTTTTTAAGAGATGGGGTATTGGTT 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK022395 unedited ATACGACTCACTATAGGCGGCCGCGAATCGGCACGGAGGCCAACCCAGGTGGGGTGGGTG AGGCTCCCAGCGGCCTACTCTAAAGCCCCTTATCTCCGGCCTCCAGTGCTTATCACATTG GGCCCACAGGGTGAGGACCCTGCTGTGCCAGGCATCCTGAGGCCCCAACTCTGTCTCCCC TACTCCCAGGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCCTGAACATCCCCCT GCTTGCTGACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAACAGATGAGGG CATTGCCTACAGGTACTGTGGGACCCTCAGCCCGGCTCAGGGAGCGCCCTGCCCCCCATT CCTGTGATGCTGGGACCACTCCTGTACAATGTCTTCTCTGCCCCCAGCCCTGTGGCTAGC AGCGGGTGGTTGGTAGTCCCTTCCTTGTCTCTGGCAGTGGGAGCTATCAGCTCCTCACTG GGAACCCTGATGTCTTCAGGGGCCTCTTTATCATCGATGGCAAGGGTGTCCTTCGCCAGA TCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAGG CCTTCCAGTACACAGACGAGCATGGGGAAGGTGAGCAGATACACACATGACACATGGGTA CATACTGAGCGCCTNCGTCACTCATGCAAACATTCACTGCCTGTCCTCTTACCTGTCCAG ATGGGTGNNTANGGCCCCAAAGAAGATTCAGCTCANGGCTTTGTCTGCAGGATGTTTCTA ATGTGGTANGAGACAAATAACGCCTGACATTCAAACCAAGTGGACAAAGGGCCGNGCTCA GTGCTCACGGTTGTATTGCCAGCACTTTGGGAAGCTGTGGCACGTGGATCACCTGAGTTC ANGAGGTCCGAAACCAGCCTGACAACATGGTTGAAAACCCGTCTCTACAAGACACANAAA ATAGCTGGA
Restriction Sites	NotI-NotI
ACCN	AK022395
Insert Size	2500 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK022395.1
RefSeq Size	3180 bp
RefSeq ORF	3180 bp
Locus ID	7001
Protein Families	Druggable Genome
Gene Summary	This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

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