SETD2 (AK026837) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; p231HBP; SET2
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK026837, the custom clone sequence may differ by one or more nucleotides ACAGATATGATACACCAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGA ACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAGCAACAGATGCAGAAC CTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTT ACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCC CACACCCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCT ACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCA GTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCAGTGCC GGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAG CAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATG GTGTGACATCACCTTATTCACAGACAACTCCACCAATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTA TATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACT ACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGG ATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGA TCCAGAAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAA AGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAA ACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAG CAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGAC TGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTA TGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAAC CAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACGCTGAATTA GAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTG TGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCT GCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGC ATGTGGTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAA ACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTAC CCTGATGATCTGTATTATATTTTAATGTATATGTGAATATATTGAAAATAATTTGTTTTTTCCTGGTTTT TGTTTGGTTTTCGTTTTGCTTTTAGCCTCTACATGCTAGGATCACAGGAAGACTTTGTAAGGACAGTTTA AGTTCTCCTGCAAGGTTTAATTTGTTATCATGTAAATATTCCAAAGCAGGCTGCCTTGTGGTTTTGGCCA GCCTTGTGCTATGTTGATAAGATTGATTTACTGCTTAAAATCACTTTACTTTATCCAATTTTTACTGAAC TTTTTATGTAAAAAAATAAAATCAATTAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK026837 unedited CATAATATGTAATACGACTCACTATAGGGCGGCCGCGAAATTCGCACCAGAGCAAACTCA AAATAAAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCG GGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTACGAAT TAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGC TCAACGGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACT GCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCACCAGG TTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCC CACACCCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGT GGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACATGTGGC AGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCA AGACTCCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTA TAGTGTTTGGGATTAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCTGCACAG TCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCA CCCTATTCACAGACAACTCCACCATTGTACCAGAGTATGTCCAGCCCAGTCTTCATATAT TCAGGGGCAACAGATTTTACAGCTCATCCACAGGAGTGTGGTACAGCAGCCCCACATTGA CTACATAGTTGACCAGGGCAGCCTAACCTTGAACCTCTGAATGGTGGGACAAAATCTTCT GAATTGCGCCCCTCTCCTCCAN 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AK026837 unedited GGAGACTCATGTACGTGGCCGCAATCNAGGATCGATTTTTTTTTTTTTTTTTTTTTTTTT TCTTTATTTGATTTTATTTTTTTACATAAAAAGTTCAGTAAAAATTGGATAAAGTAAAGT GATTTTAAGCAGTAAATCAATCTTATCAACATAGCACAAGGCTGGCCAAAACCACAAGGC AGCCTGCTTTGGAATATTTACATGATAACAAATTAAACCTTTTAGGAGAACTTAAACTGT CCTTACAAAGTCTTCCTGTGATCCTAGCATGTAGAGGCTAAAAGCAAAACGAAAACCAAA CAAAAACCAGGAAAAAACAAATTATTTTCAATATATTCACATATACATTAAAATATAATA CAGATCATCAGGGTAAAGGGTTGTGGGTGGGGATGCCCATGGGTCTGTGCGCTGACAGCA CCGCCCAGGAGAAGACCCAGGTTTAAAAATGGAGTCAGGTCTGGCCAGGGTCTTTTCTAA GCCCTTGCACCTCTGATGGGTTCTAACCACATGCCAACAGCTCACAACTAGGTAATCACT TGTAGATGGAGTTCATTTTTGTGGCCTTCAGTTGACATCTGCAGGGTTGAATTCCCCCAG GTGATGTATCATCAGTAGCACACTGCTGACAGGGGTGGGACAGAAAGGCCCACAGGATTT CCTCTCCCTAAAGGCTGTGTTACCTGAGCACCCATCCTCCCCCCCTGGGCCAACAGTCAC TCTAATTCAGAGGCCTCTTTGGGGTTGTAAACAGCCCCCAACTTCTGGATGTACTTCTTA AAGGACCCCCTTGGTTTTGGGGTCACAATCTCATTGGACTCCAGGGCCCCAAGGTTATTT ACAGAACTTCAGCTCCTTTATCATAACCCCCGGAGTCAACTTGGGACCCAAAAGTTTT
Restriction Sites	NotI-NotI
ACCN	AK026837
Insert Size	2300 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK026837.1
RefSeq Size	2095 bp
RefSeq ORF	2095 bp
Locus ID	29072
Domains	WW
Protein Families	Druggable Genome
Protein Pathways	Lysine degradation
Gene Summary	Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

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