IRF5 (NM_032643) Human Untagged Clone
CAT#: SC104269
IRF5 (untagged)-Human interferon regulatory factor 5 (IRF5), transcript variant 2
CNY 3,656.00
Cited in 2 publications. |
Product images
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | SLEB10 |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC104269 sequence for NM_032643 edited (data generated by NextGen Sequencing)
ATGAACCAGTCCATCCCAGTGGCTCCCACCCCACCCCGCCGCGTGCGGCTGAAGCCCTGG CTGGTGGCCCAGGTGAACAGCTGCCAGTACCCAGGGCTTCAATGGGTCAACGGGGAAAAG AAATTATTCTGCATCCCCTGGAGGCATGCCACAAGGCATGGTCCCAGCCAGGACGGAGAT AACACCATCTTCAAGGCCTGGGCCAAGGAGACAGGGAAATACACCGAAGGCGTGGATGAA GCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGACTTC CGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTC TGCTCCAATGGCCCTGCTCCCACAGACTCCCAGCCCCCTGAGGATTACTCTTTTGGTGCA GGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTCACA GAGGATGTCAAGTGGCCGCCTACTCTGCAGCCGCCCACTCTGCRGCCGCCTACTCTGCAG CCGCCCACTCTGCAGCCGCCCGTGGTGCTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTG GCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAGCCT GGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATC AGCCCCCACATGCTGCCTCTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCA CCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTGGAG GCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCC AGCCCTGAGGACATCCCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTC CTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTGTGT CAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCC ATCCAGCGGGAGGTCAAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATC CTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTTGGG GAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCT GTAGCAGCTCGACTGCTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGT ATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAGGAG CTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGA GCAGGCCTTGGTGTTGGCCAGGGGCCCTGGCCTATGCACCCAGCTGGCATGCAATAA Clone variation with respect to NM_032643.3 501 c=>t;524 g=>r >OriGene 5' read for NM_032643 unedited
GGATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTGCTCCCTG GCGCAGCCACGCAGGCGCACCGCAGACAGACCCCTCTGCCATGAACCAGTCCATCCCAGT GGCTCCCACCCCACCCCGCCGCGTGCGGCTGAAGCCCTGGCTGGTGGCCCAGGTGAACAG CTGCCAGTACCCAGGGCTTCAATGGGTCAACGGGGAAAAGAAATTATTCTGCATCCCCTG GAGGCATGCCACAAGGCATGGTCCCAGCCAGGACGGAGATAACACCATCTTCAAGGCCTG GGCCAAGGAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAA GGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGACTTCCGCCTCATCTACGACGGGCC CCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCC CACAGACTCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGA GGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTCACAGAGGATGTCAAGTGGCCGCC CACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCC CCGTGGTGCTGGGGTCCCCCNTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAA CCCTGCTGGCTTCAGGGAGCTTCTCTTCTGAGTCCTGGAGCCTGNGCCCCTGCCTGCCAG CCTGCCCCCTGCANGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCCATGCTGNCT CTGACGANCTGGAGNACAAGNTTCAGTACCGGGGGCGGNCACCCCGGGCCTCACATCAGC ACCCCCATGGTGNCGCTCTCTCANCAGCTGGAGCACCAGAACAGGTGGACTCTTCGCCCA TAGCTGGAGCAGGCN >OriGene 3' read for NM_032643 unedited
CCCGCATTCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAATTTATACAGGAAAAGGTTTAT TTGGCTCACAGTTCTGATGGCTGGGCATCAAGATTGGGCATCTGCACCTGGTAAGGGCCT GGGGCAGCTTCCACTCAATGGCTGAAGGCAGAAAGTGGGCTGGAGTGTGCAGAGATGACA CAGATGAAGTGAGAGCGGGTAGGTGCCAGGCTCTTTAACAACCAGCTCTGGGGGGACTAA GAGAACTCACTCACTGTCCCCACCTCGGGGGACAATATAATAAATATATTAAATATATCA GGATGATTTACATGCACTGCCCTGATATATTTAATAGCACAGGAATATACACAAGAGAGT GACAGATTTGAATGGTCCCAAATGCAGCTGCAATGCTAGCCCACCCTTTTATGGGAAAAC TGATTCTGACAGTTTTCCAGACTGTGCACACATTTAAAATTCCACACCCTTGCTTCAGCC AGCTTCCTCCTGGAAGGCAAAGCCAGCCAGGTGAGTGTTTATGAAGGCCCAACTGACCCA TCAGCCCAGAAGCCAGGCCCTCCCAGTGCCAATGGTCGCAAGCTGAGCGCAAGTGCTTGG GGAGCGGGCCAGTTGGCATCCGAAACAGGGCCTGGTGGAGCAGCATGCGAGCAACTGGTA GTAGTATAAGGGAAAGAACAAGCTGAGCCTGTTCTCTACATTCATTATTCGCAAAAATAC ATAANAAATCTATTTCTGCCTCCAGGCTCTTGGACTCTCAGGAAAGGCGGTAGCTGCCAG CCCTCGAGCATCTGATTTGATACCCTAGCGCCTCACTCATTTTATTCTCAGAAGACACGG CAGATGAGGCAGCGGAGTCTCACACCAAGGGAATTACGCCCATGCCCTGCATAGCGCTCG GGGGGGGACTTGGTCACACCACTCTGTCTTTTGTTGCACAAGGAATGGGCATTCCAAAAG TCGCCACCTTAGCATTCCTCTATCACTAGCCCCAGGTGGAGAT |
Restriction Sites | NotI-NotI |
ACCN | NM_032643 |
Insert Size | 2770 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_032643.3, NP_116032.1 |
RefSeq Size | 2771 bp |
RefSeq ORF | 1497 bp |
Locus ID | 3663 |
UniProt ID | Q13568 |
Domains | IRF |
Protein Families | Transcription Factors |
Protein Pathways | Toll-like receptor signaling pathway |
Gene Summary | This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016] Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 9. The encoded isoform (b) is shorter, compared to isoform d. Variants 2, 3, and 6 encode the same isoform. |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
,Jiang, SH;Athanasopoulos, V;Ellyard, JI;Chuah, A;Cappello, J;Cook, A;Prabhu, SB;Cardenas, J;Gu, J;Stanley, M;Roco, JA;Papa, I;Yabas, M;Walters, GD;Burgio, G;McKeon, K;Byers, JM;Burrin, C;Enders, A;Miosge, LA;Canete, PF;Jelusic, M;Tasic, V;Lungu, AC;Alexander, SI;Kitching, AR;Fulcher, DA;Shen, N;Arsov, T;Gatenby, PA;Babon, JJ;Mallon, DF;de Lucas Collantes, C;Stone, EA;Wu, P;Field, MA;Andrews, TD;Cho, E;Pascual, V;Cook, MC;Vinuesa, CG;,
Nat Commun
,PubMed ID 31101814
[IRF5]
|
Rotavirus NSP1 Inhibits Expression of Type I Interferon by Antagonizing the Function of Interferon Regulatory Factors IRF3, IRF5, and IRF7
,Mario Barro and John T Patton,
J Virol. 2007 May;81(9):4473-81.
[IRF5]
|
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