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CBLB (NM_170662) Human Untagged Clone
CAT＃: SC107022
CBLB (untagged)-Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB)
CNY 10,800.00
| Cited in 2 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Cbl-b; Nbla00127; RNF56 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC107022 sequence for NM_170662 edited (data generated by NextGen Sequencing)
ATGGCAAACTCAATGAATGGCAGAAACCCTGGTGGTCGAGGAGGAAATCCCCGAAAAGGT CGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTGGACCCCCTAAGCAAGCTGCC GCAGATCGCAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGC CAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGATATTTTGCCTGAT ACATATCAGCATTTACGACTTATATTGAGTAAATATGATGACAACCAGAAACTTGCCCAA CTCAGTGAGAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGG GCAATAAGACTCTTTAAAGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGA CGAAATCTCACAAAACTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAAGCAATC TTTCCCAATGGTCAATTCCAGGGAGATAACTTTCGTATCACAAAAGCAGATGCTGCTGAA TTCTGGAGAAAGTTTTTTGGAGACAAAACTATCGTACCATGGAAAGTATTCAGACAGTGC CTTCATGAGGTCCACCAGATTAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATT GATTTAACTTGCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT CAGCCTTGGGGCTCTATTTTGCGGAATTGGAATTTCTTAGCTGTGACACATCCAGGTTAC ATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAACCC GGAAGCTATATTTTCCGGTTAAGTTGCACTCGATTGGGACAGTGGGCCATTGGCTATGTG ACTGGGGATGGGAATATCTTACAGACCATACCTCATAACAAGCCCTTATTTCAAGCCCTG ATTGATGGCAGCAGGGAAGGATTTTATCTTTATCCTGATGGGAGGAGTTATAATCCTGAT TTAACTGGATTATGTGAACCTACACCTCATGACCATATAAAAGTTACACAGGAACAATAT GAATTATATTGTGAAATGGGCTCCACTTTTCAGCTCTGTAAGATTTGTGCAGAGAATGAC AAAGATGTCAAGATTGAGCCTTGTGGGCATTTGATGTGCACCTCTTGCCTTACGGCATGG CAGGAGTCGGATGGTCAGGGCTGCCCTTTCTGTCGTTGTGAAATAAAAGGAACTGAGCCC ATAATCGTGGACCCCTTTGATCCAAGAGATGAAGGCTCCAGGTGTTGCAGCATCATTGAC CCCTTTGGCATGCCGATGCTAGACTTGGACGACGATGATGATCGTGAGGAGTCCTTGATG ATGAATCGGTTGGCAAACGTCCGAAAGTGCACTGACAGGCAGAACTCACCAGTCACATCA CCAGGATCCTCTCCCCTTGCCCAGAGAAGAAAGCCACAGCCTGACCCACTCCAGATCCCA CATCTAAGCCTGCCACCCGTGCCTCCTCGCCTGGATCTAATTCAGAAAGGCATAGTTAGA TCTCCCTGTGGCAGCCCAACAGGTTCACCAAAGTCTTCTCCTTGCATGGTGAGAAAACAA GATAAACCACTCCCAGCACCACCTCCTCCCTTAAGAGATCCTCCTCCACCGCCACCTGAA AGACCTCCACCAATCCCACCAGACAATAGACTGAGTAGACACATCCATCATGTGGAAAGC GTGCCTTCCAGAGACCCGCCAATGCCTCTTGAAGCATGGTGCCCTCGGGATGTGTTTGGG ACTAATCAGCTTGTGGGATGTCGACTCCTAGGGGAGGGCTCTCCAAAACCTGGAATCACA GCAAGTTCAAATGTCAATGGAAGGCACAGTAGAGTGGGCTCTGACCCAGTGCTTATGCGG AAACACAGACGCCATGATTTGCCTTTAGAAGGAGCTAAGGTCTTTTCCAATGGTCACCTT GGAAGTGAAGAATATGATGTTCCTCCCCGGCTTTCTCCTCCTCCTCCAGTTACCACCCTC CTCCCTAGCATAAAGTGTACTGGTCCGTTAGCAAATTCTCTTTCAGAGAAAACAAGAGAC CCAGTAGAGGAAGATGATGATGAATACAAGATTCCTTCATCCCACCCTGTTTCCCTGAAT TCACAACCATCTCATTGTCATAATGTAAAACCTCCTGTTCGGTCTTGTGATAATGGTCAC TGTATGCTGAATGGAACACATGGTCCATCTTCAGAGAAGAAATCAAACATCCCTGACTTA AGCATATATTTAAAGGGAGATGTTTTTGATTCAGCCTCTGATCCCGTGCCATTACCACCT GCCAGGCCTCCAACTCGGGACAATCCAAAGCATGGTTCTTCACTCAACAGGACGCCCTCT GATTATGATCTTCTCATCCCTCCATTAGGTGAAGATGCTTTTGATGCCCTCCCTCCATCT CTCCCACCTCCCCCACCTCCTGCAAGGCATAGTCTCATTGAACATTCAAAACCTCCTGGC TCCAGTAGCCGGCCATCCTCAGGACAGGATCTTTTTCTTCTTCCTTCAGATCCCTTTGTT GATCTAGCAAGTGGCCAAGTTCCTTTGCCTCCTGCTAGAAGGTTACCAGGTGAAAATGTC AAAACTAACAGAACATCACAGGACTATGATCAGCTTCCTTCATGTTCAGATGGTTCACAG GCACCAGCCAGACCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCACAGA AAACCCCATGGGCCTGAGGCGGCATTGGAAAATGTCGATGCAAAAATTGCAAAACTCATG GGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAGATAGCCCAGAATAATGTC GAAGTTGCCCGGAGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTA AATCTATAG Clone variation with respect to NM_170662.3 1581 g=>a;1863 g=>a >OriGene 5' read for NM_170662 unedited
GGGCGGCCCGCGAATTCGCACGAGGCCTGCTAGTGCTGCTGCGGCGTCCCGCGGCCTCCC CGAGTCGGGCGGGAGGGGAGAGCGGGTGTGGATTTGTCTTGACGGTAATTGTTGCGTTTC CACGTCTCGGAGGCCTGCGCGCTGGGTTGCTCCTTCTTCGGGAGCGAGCTGTTCTCAGCG ATCCCACTCCCAGCCGGGGCTCCCCACACACACTGGGCTGCGTGCGTGTGGAGTGGGACC CGCGCACACGCGTGTCTCTGGACAGCTACGGCGCCGAAAGAACTAAAATTCCAGATGGCA AACTCAATGAATGGCAGAAACCCTGGTGGTCGAGGAGGAAATCCCCGAAAAGGTCGAATT TTGGGTATTATTGATGCTATTCAGGATGCAGTTGGACCCCCTAAGCAAGCTGCCGCAGAT CGCAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAAT CCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGATATTTTGCCTGATACATAT CAGCATTTACGACTTATATTGAGTAAATATGATGACAACCAGAAACTTGCCCAACTCAGT GAGAATGGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAAT AAGACTCTTNANAGAAGGCAAGGGAGAGAATGTATTGAAGAACAGTCACAGGACAGACGA AATCTCACAAACTGTCCCTAATCTTCAGTCACATGCTGGCAGAATCAAGCATCCTCCCCA TGGTCATTCCAGGGAGATACTTTCGATACAAAGCAGAGCTGCTGATCTGGGGAAAGAGTT TTGGAGACAAACATCGACAATGGAAGA >OriGene 3' read for NM_170662 unedited
NNTTTTTTAGCTTGNACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTT GCATTAGTTTGATCAGTTGAAAATCAGAACCTTCAAAGCATCTTGTGAATGAGAGAAATG GAACTGGACCTGGGCAAGGCATGGGGATGGTAGAGATCCATATGAATAAATGATTTAGCT GTTGATGTGGACAGCAAGAGAGTTGGTGGGAAATGTTACAGCAGACCTGACCACGCTACA AAGGGTCTGTGAAGAACACAGTACAGGTATCAAAACACCAAAACAAAACTAAACTAAAAA CAAGAACAAACTGCAACTTTGCCAAACTGTAAACAAGGTAAAGCATTTCACAGGTTCAAA GTTCAAGGGAAGTAAACGTCTTTAAATTATTTTTGTCAGTTCAACCCTGATTTAAAAATA TGGCTAGCAAAAACAAGGAAGCCACAGCTGTCGACATCCTGAGCAAGCATCGGTCTCCTT TGAGAAGCTGCACTCCCAAGCCTCTTCTCAAGCTGCTACACGAGGAGGAGACACTTCTCT CTTGAATTCCATCTCAGTTCTCTTTATTTCCACACTCTTGGAATACATCGATTGCTTTCC ATTTTGGTGTCTACAGTTCTGGCTGCTATAGATTTAGACGTGGGGATACTGGAGGAAGGG AAGGCAAATTCTCGGAGGATGCTNCGGGGCACTTCGACATTATTCTGGGCTATCTCTAAG GCTCTCTTCACCTCTTCAAGGCATACCCTCTCCATGGAGTTTGCAATTTTGCATCGAATT TTCCATGCCGCTCAGCCTGGGGGTTTTCTGTGGTGAATTCTGGTGCAGCTTGGCGGCCGG TTTAGGGGGGTCTGGTTGGCGCTGTAACATTTGACTGAAGAGTGACTAGCCCGGGAGTTC GGAAGTTGCATTC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_170662 |
| Insert Size | 3580 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_170662.3, NP_733762.2 |
| RefSeq Size | 3976 bp |
| RefSeq ORF | 2949 bp |
| Locus ID | 868 |
| UniProt ID | Q13191 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis |
| Gene Summary | This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017] Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Pro-oncogenic roles of HLXB9 in insulinoma cells through interaction with Nono and downregulation of the c-Met inhibitor Cblb
,Desai, SS;Kharade, SS;Parekh, VI;Iyer, S;Agarwal, SK;,
J. Biol. Chem.
,PubMed ID 26342078
[CBLB]
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The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
,Igor Vivanco, Daniel Rohle, Matthias Versele, Akio Iwanami, Daisuke Kuga, Barbara Oldrini, Kazuhiro Tanaka, Julie Dang, Sara Kubek, Nicolaos Palaskas, Teli Hsueh, Michael Evans, David Mulholland, Daniel Wolle, Sigrid Rajasekaran, Ayyappan Rajasekaran, Linda M. Liau, Timothy F. Cloughesy, Ivan Dikic, Cameron Brennan, Hong Wu, Paul S. Mischel, Timothy Perera, and Ingo K. Mellinghoff,
PNAS, Apr 2010; 107: 6459 - 6464
[CBLB]
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Other Versions
| SKU | Description | Size | Price |
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| RC206047 | CBLB (Myc-DDK-tagged)-Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB) |
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| RC206047L1 | Lenti ORF clone of Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), Myc-DDK-tagged |
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| RC206047L2 | Lenti ORF clone of Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), mGFP tagged |
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| RC206047L3 | Lenti ORF clone of Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), Myc-DDK-tagged |
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| RC206047L4 | Lenti ORF clone of Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), mGFP tagged |
CNY 13,184.00 |
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| RG206047 | CBLB (tGFP-tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB) |
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