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CKII alpha (CSNK2A1) (NM_177559) Human Untagged Clone
CAT＃: SC107027
CSNK2A1 (untagged)-Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1
CNY 5,488.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CK2A1; Cka1; Cka2; CKII; OCNDS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_177559 edited
ATGTCGGGACCCGTGCCAAGCAGGGCCAGAGTTTACACAGATGTTAATACACACAGACCT CGAGAATACTGGGATTACGAGTCACATGTGGTGGAATGGGGAAATCAAGATGACTACCAG CTGGTTCGAAAATTAGGCCGAGGTAAATACAGTGAAGTATTTGAAGCCATCAACATCACA AATAATGAAAAAGTTGTTGTTAAAATTCTCAAGCCAGTAAAAAAGAAGAAAATTAAGCGT GAAATAAAGATTTTGGAGAATTTGAGAGGAGGTCCCAACATCATCACACTGGCAGACATT GTAAAAGACCCTGTGTCACGAACCCCCGCCTTGGTTTTTGAACACGTAAACAACACAGAC TTCAAGCAATTGTACCAGACGTTAACAGACTATGATATTCGATTTTACATGTATGAGATT CTGAAGGCCCTGGATTATTGTCACAGCATGGGAATTATGCACAGAGATGTCAAGCCCCAT AATGTCATGATTGATCATGAGCACAGAAAGCTACGACTAATAGACTGGGGTTTGGCTGAG TTTTATCATCCTGGCCAAGAATATAATGTCCGAGTTGCTTCCCGATACTTCAAAGGTCCT GAGCTACTTGTAGACTATCAGATGTACGATTATAGTTTGGATATGTGGAGTTTGGGTTGT ATGCTGGCAAGTATGATCTTTCGGAAGGAGCCATTTTTCCATGGACATGACAATTATGAT CAGTTGGTGAGGATAGCCAAGGTTCTGGGGACAGAAGATTTATATGACTATATTGACAAA TACAACATTGAATTAGATCCACGTTTCAATGATATCTTGGGCAGACACTCTCGAAAGCGA TGGGAACGCTTTGTCCACAGTGAAAATCAGCACCTTGTCAGCCCTGAGGCCTTGGATTTC CTGGACAAACTGCTGCGATATGACCACCAGTCACGGCTTACTGCAAGAGAGGCAATGGAG CACCCCTATTTCTACACTGTTGTGAAGGACCAGGCTCGAATGGGTTCATCTAGCATGCCA GGGGGCAGTACGCCCGTCAGCAGCGCCAATATGATGTCAGGGATTTCTTCAGTGCCAACC CCTTCACCCCTTGGACCTCTGGCAGGCTCACCAGTGATTGCTGCTGCCAACCCCCTTGGG ATGCCTGTTCCAGCTGCCGCTGGCGCTCAGCAGTAA >OriGene 5' read for NM_177559 unedited
TGTAATACGACTCACTATAGGGCGGCCGCGCAATTCGCACGAGGGTCTCCCCCCTCCATC GCCGCCATATTGTCTGTGTGAGCAGAGGGGAGAGCGGCCGCCGCCGCTGCCGCTTCCACC ACAGCTCTATCAAGGCTTGTCAAGCAGTGTGCTCATCACATCGTAAATCATGCAGCGTGG AACCTCATAAAATCTCCAACAAACATCATTCACCCATACTGACTAGTTTCACATCTCTTT GTTTGAAGAAAACAGGTCTGAAACAAGGTCTTACCCCCAGCTGCTTCTGAACACAGTGAC TGCCAGATCTCCAAACATCAAGTCCAGCTTTGTCCGCCAACCTGTCTGACATGTCGGGAC CCGTGCCAAGCAGGGCCAGAGTTTACACAGATGTTAATACACACAGACCTCGAGAATACC TGGGATTACGAGTCACATGTGGTGGAATGGGGAAATCAAGATGACTACCAGCTGGTTCGA AAATTACGCCGAGGTAAATACAGTGAAGTATTTGAAGCCATCAACATCACAAATAATGAA AAAGTTGTTGCTAAAATTCTCAAGCCAGCAAAAAAGAACAAATTAAGCGTGAAATAAAGA TTTTGGAGAATTTGAGAGGAGGTCCCACCATCATCACACTGGCAGACATGTAAAAGACCC TGTGTCACGAACCCCCGCCTTGGTTTTGAACACCAAACACACAGACTTAAGCAATTGTAC CAGACGTCTACAGACTATGAATATCCGATCTTACATGTATGACATTCCGAAAGCCCTTGA ATATTGTCCCAGCATGGGAATTATGCACAGAGATGCCAGCCCCATAAAGTCATGATTGAC CCGGACCCCAAAAGCCTCACCAATAGAACCGCGTTTGGCTGAGTTTTATCATCCGGCCAA CAATAAAGCCCGCAGTGCCTCCGAACCTTAAGGCCCGGGCTTC >OriGene 3' read for NM_177559 unedited
CTGTTACCGCGCCCGCATTCTANATCGAGTTTTTTCTTTTTTTTTTTCACTATGAAGGAC AAAGTATTATATATATACACACAGCAAGGGGTGGCGGGGCTGTAACAAGAGAGTTTATAG TTTTCCCACAATTACAGGTCTACCATTTCAGCTTCAATGGAGATAGTGGCTCTGCTCCTA CCTCTCAAGATACATTTACAAGACTGAGGATCAGGTCTTCTCACTGGATGGCATGTGAGG GAAGGGGACGGTCGGAGGAAAAGAAGGTAGAAAGCTTAAAATGGAAGTCAGTGTGGCCAC ATCTCCCATTAGCTCTAGCATGAAACCTGTACAGACAATGTTTGTTTCTTTTGTAAAAAG CAGTAAGTTATGCCCAGTAACTAAATGAATTCAAAATGGCCAAGACAAAGAAAACTAAGA AAGATTTTGCCTTCCCTCTCCTACCAGCTATGGAGCACAGCATGTTGGGAGATGAACAGG GAAAAGACCAAGGTAAGGAGCCTGNGAGGGAAGGTATCAACATTTTAAACTGAACTAAAA ATAAAAGTATAAATGAGTTGGATTTAGGGTTAGATCAGTAAGACATGATTCTTACTGAAC AGAAGTTTTTAGTATCTGTCTGCATTTTGGGTAGATTTTCAACATCTTGATGTAACTAAG ACACACTTCCAACAGAGCCACTAGGATAACCCCACTGAAGCGCTTATGGAGTAAAGTGAT GTAAGCGACCAGNCAGCAGTCCACTGCTCCTATAGATTGGGTCTNCCCTTCCTCTTNNCT TCCTTCCTTNCTTTCTGGCTCCCCTGAGAAACTACATTTTTGTATTCTCTGGAGAAGACC CCGAAATACCAACCCCTTAAGTGTGGGACCGTGGAAGAAACATGTGTGGAATGGGAAGAA TTCCCCACTAAATGCACCACCCCGGATTGAGGCTGGTTACCTTTGTCCTTTTTGATAAGA A |
| Restriction Sites | NotI-NotI |
| ACCN | NM_177559 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_177559.2, NP_808227.1 |
| RefSeq Size | 2849 bp |
| RefSeq ORF | 1176 bp |
| Locus ID | 1457 |
| UniProt ID | P68400 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase |
| Protein Pathways | Adherens junction, Tight junction, Wnt signaling pathway |
| Gene Summary | Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018] Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same protein. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392
,Woksepp, H;, ;Saini, R;Zakharchenko, O;Gautier, A;Souchelnytskyi, N;Souchelnytskyi, S;, ;, ;, ;, ;, ;,
exp-oncology
,PubMed ID 31868330
[CSNK2A1]
|
|
CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression
,Trembley, JH;Kren, BT;Abedin, MJ;Shaughnessy, DP;Li, Y;Dehm, SM;Ahmed, K;,
Pharmaceuticals (Basel) 2019
,PubMed ID 31197122
[CSNK2A1]
|
|
CK2-mediated phosphorylation of Hsp90ß as a novel mechanism of rifampin-induced MDR1 expression
,Kim, SW;Hasanuzzaman, M;Cho, M;Heo, YR;Ryu, MJ;Ha, NY;Park, HJ;Park, HY;Shin, JG;,
J. Biol. Chem.
,PubMed ID 25995454
[CSNK2A1]
|
|
Protein Kinase Casein Kinase 2–Mediated Upregulation of N-Cadherin Confers Anoikis Resistance on Esophageal Carcinoma Cells
,Hyeonseok Ko, Seongrak Kim, Cheng-Hao Jin, Eunjung Lee, Sunyoung Ham, Jong In Yook, and Kunhong Kim,
Mol. Cancer Res., Aug 2012; 10: 1032 - 1038.
[CSNK2A1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222256 | CSNK2A1 (Myc-DDK-tagged)-Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1 |
CNY 5,488.00 |
|
| RC222256L3 | Lenti-ORF clone of CSNK2A1 (Myc-DDK-tagged)-Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1 |
CNY 7,888.00 |
|
| RC222256L4 | Lenti-ORF clone of CSNK2A1 (mGFP-tagged)-Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1 |
CNY 5,890.00 |
|
| RG222256 | CSNK2A1 (tGFP-tagged) - Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1 |
CNY 4,370.00 |
|
| SC323516 | CSNK2A1 (untagged)-Kinase deficient mutant (K68M) of Human casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1 |
CNY 5,488.00 |
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