United States
Germany
Japan
United Kingdom
China
Aromatase (CYP19A1) (NM_031226) Human Untagged Clone
CAT＃: SC107980
CYP19A1 (untagged)-Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2
CNY 3,752.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_031226 edited
GGGCGGCCGCGAATTCGGCACGAGGAACCGTGGAGGCAAACAGGAAGGTGAAGAAGAACT TATCCTATCAGGACGGAAGGTCCTGTGCTCGGGATCTTCCAGACGTCGCGACTCTAAATT GCCCCCTCTGAGGTCAAGGAACACAAGATGGTTTTGGAAATGCTGAACCCGATACATTAT AACATCACCAGCATCGTGCCTGAAGCCATGCCTGCTGCCACCATGCCAGTCCTGCTCCTC ACTGGCCTTTTTCTCTTGGTGTGGAATTATGAGGGCACATCCTCAATACCAGGTCCTGGC TACTGCATGGGAATTGGACCCCTCATCTCCCACGGCAGATTCCTGTGGATGGGGATCGGC AGTGCCTGCAACTACTACAACCGGGTATATGGAGAATTCATGCGAGTCTGGATCTCTGGA GAGGAAACACTCATTATCAGCAAGTCCTCAAGTATGTTCCACATAATGAAGCACAATCAT TACAGCTCTCGATTCGGCAGCAAACTTGGGCTGCAGTGCATCGGTATGCATGAGAAAGGC ATCATATTTAACAACAATCCAGAGCTCTGGAAAACAACTCGACCCTTCTTTATGAAAGCT CTGTCAGGCCCCGGCCTTGTTCGTATGGTCACAGTCTGTGCTGAATCCCTCAAAACACAT CTGGACAGGTTGGAGGAGGTGACCAATGAATCGGGCTATGTGGACGTGTTGACCCTTCTG CGTCGTGTCATGCTGGACACCTCTAACACGCTCTTCTTGAGGATCCCTTTGGACGAAAGT GCTATCGTGGTTAAAATCCAAGGTTATTTTGATGCATGGCAAGCTCTCCTCATCAAACCA GACATCTTCTTTAAGATTTCTTGGCTATACAAAAAGTATGAGAAGTCTGTCAAGGATTTG AAAGATGCCATAGAAGTTCTGATAGCAGAAAAAAGACGCAGGATTTCCACAGAAGAGAAA CTGGAAGAATGTATGGACTTTGCCACTGAGTTGATTTTAGCAGAGAAACGTGGTGACCTG ACAAGAGAGAATGTGAACCAGTGCATATTGGAAATGCTGATCGCAGCTCCTGACACCATG TCTGTCTCTTTGTTCTTCATGCTATTTCTCATTGCAAAGCACCCTAATGTTGAAGAGGCA ATAATAAAGGAAATCCAGACTGTTATTGGTGAGAGAGACATAAAGATTGATGATATACAA AAATTAAAAGTGATGGAAAACTTCATTTATGAGAGCATGCGGTACCAGCCTGTCGTGGAC TTGGTCATGCGCAAAGCCTTAGAAGATGATGTAATCGATGGCTACCCAGTGAAAAAGGGG ACAAACATTATCCTGAATATTGGAAGGATGCACAGACTCGAGTTTTTCCCCAAACCCAAT GAATTTACTCTTGAAAATTTTGCAAAGAATGTTCCTTATAGGTACTTTCAGCCATTTGGC TTTGGGCCCCGTGGCTGTGCAGGAAAGTACATCGCCATGGTGATGATGAAAGCCATCCTC GTTACACTTCTGAGACGATTCCACGTGAAGACATTGCAAGGACAGTGTGTTGAGAGCATA CAGAAGATACACGACTTGTCCTTGCACCCAGATGAGACTAAAAACATGCTGGAAATGATC TTTACCCCAAGAAACTCAGACAGGTGTCTGGAACACTAGAGAAGGCTGGTCAGTACCCAC TCTGGAGCATTTCTCATCAGTAGTTCACATACAAATCATCCATCCTTGCCAATAGTGTCA TCCTCACAGTGAACACTCAGTGGCCCATGGCATTTTATAGGCATACCTCCTATGGGTTGT CACCAAGCTAGGTGCTATTTGTCATCTGCTCCTGTTCACACCAGAGAACCAGGCTACAAG AGAAAAAGCAGAGGCCAAGAGTTTGAGGGAGAAATAGTCGGTGAAGAAACCGTATCCATA AAGACCCGATTCCACCAAATGTGCTTTGAGAAGGATAGGCCTTCATTAACAAAATGTATG TCTGGTTCCCCAGTAGAGCTCTACTGCCTCAACCC >OriGene 5' read for NM_031226 unedited
CACGAGNAACCGTGGNAGCAAACAGGAAGGTGAAGAAGAACTTATCCTATCAGGACGGAA GGTCCTGTGCTCGGGATCTTCCAGACGTCGCGACTCTAAATTGCCCCCTCTGAGGTCAAG GAACACAAGATGGTTTTGGAAATGCTGAACCCGATACATTATAACATCACCAGCATCGTG CCTGAAGCCATGCCTGCTGCCACCATGCCAGTCCTGCTCCTCACTGGCCTTTTTCTCTTG GTGTGGAATTATGAGGGCACATCCTCAATACCAGGTCCTGGCTACTGCATGGGAATTGGA CCCCTCATCTCCCACGGCAGATTCCTGTGGATGGGGATCGGCAGTGCCTGCAACTACTAC AACCGGGTATATGGAGAATTCATGCGAGTCTGGATCTCTGGAGAGGAAACACTCATTATC AGCAAGTCCTCAAGTATGTTCCACATAATGAAGCACAATCATTACAGCTCTCGATTCGGC AGCAAACTTGGGCTGCAGTGCATCGGTATGCATGAGAGAGGCATCATATTTAACAACAAT CCAGAGCTCTGGANAACAACTCGACCCTTCTTTATGAAAGCTCTGTCAGGCCCCGGCCTT GTTCGTATGGTCACAGTCTGTGCTGAATCCCTCANACACATCTGGACAGGTTGGAGGAGG TG >OriGene 3' read for NM_031226 unedited
TATCTTTGGNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGGGAACA TGCCAAAGGATTTTTATTTGAATTTGAAGTGCATCATGTGAATTTTTTTTTCTACAGCAG ACACAGGGCCCTAATAATACTTAACCCAGGCTATTACTAAATTAGTTTGTATTACTTGAT GATTATATATAGTTTGTATTACCTGAATCTACAGGTAACACAATGAATTGTAGCACAGGC AAGTGGCTGAGGCATAAATCGACAGACTGGGAAAGAATTTCCTCTGATTAAACTTTTGCC ACAGACAGATCATATGTAGACAAACAGGAATTAATTGGGCTTAATTCACAGCAAGGGTCA AATGCTGAATTTCTAAGCATTTCTCCAAAGACTATGAATGTTGCTTTTCCACCTCCACAG AAAACAAAATTAAAGTACTTTAATTCACACTAGCAGGTGGGTTTGGCCCCAGGTACCCTG ACATTGGCCTGGTCTTTCTAATCAACTTGAGTGTTTCTGCCCCAGACATAAAAATCCCCT TGGGTTGAGGCAGTAGAGCTCTACTGGGGAACCAGACATACATTNTGTTAATGAAGGCCT ATCCTTCTCAAAGCACATTTGGTGGAATCGGGTCTTTATGGATACGGNTTCTTCACCGAC TATTTCTCCCTCAAACTCTTGGCCTCTGCTTTNTCTCTTGTAGCCTGGNTCTCTGGGTGT GACAGGAGCAGATGACAAATAGCACCTAGCTTGGGTGACACCCCATAGAGGTATGCCTAT NAAATGCCATGGGCCACTGANNTGTCACTGTNGAGATGACACTATTGGCAGGNATGGATG ATTTNGNATGTGAACTACTGATGAGAAATGCTNNCAGGTGGGTACTGACCAGNCTTTNCT AGTGTTCCAGACACCTGNCTGATTNCTTGGGGTAAAGATCATTNTCAGCATGTNTTTTAG TCTCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_031226 |
| Insert Size | 2800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_031226.1, NP_112503.1 |
| RefSeq Size | 3116 bp |
| RefSeq ORF | 1512 bp |
| Locus ID | 1588 |
| UniProt ID | P11511 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450 |
| Protein Pathways | Androgen and estrogen metabolism, Metabolic pathways |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] Transcript Variant: This variant (2) represents the use of an alternate promoter and contains alternate 5' exons (I.1 and 2a), compared to variant 4. All variants encode the same protein. The 5' end of this transcript contains long terminal repeat (LTR) sequence, initiates from an LTR promoter and results in placenta-specific expression. (PMID: 19577618). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Methylseleninic acid is a novel suppressor of aromatase expression
,Ruijuan Gao, Lijuan Zhao, Xichun Liu, Brian G Rowan, Martin Wabitsch, Dean P Edwards, Yoshihiro Nishi, Toshihiko Yanase, Qun Yu, and Yan Dong,
J. Endocrinol., Feb 2012; 212: 199 - 205.
[CYP19A1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221358 | CYP19A1 (Myc-DDK-tagged)-Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2 |
CNY 3,744.00 |
|
| RC221358L1 | Lenti ORF clone of Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2, Myc-DDK-tagged |
CNY 6,144.00 |
|
| RC221358L2 | Lenti ORF clone of Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC221358L3 | Lenti ORF clone of Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC221358L4 | Lenti ORF clone of Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2, mGFP tagged |
CNY 6,144.00 |
|
| RG221358 | CYP19A1 (tGFP-tagged) - Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2 |
CNY 4,370.00 |
其它Aromatase产品
