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TRAF6 (NM_004620) Human Untagged Clone
CAT＃: SC109844
TRAF6 (untagged)-Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2
CNY 3,896.00
| Cited in 3 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MGC:3310; RNF85 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004620 edited
GAATTCGGCACGAGGAAGCAGTGGCGTCCGCAGCTGGGGCTTGGCCTGCGGGCGGCCAGC GAAGGTGGCGAAGGCTCCCACTGGATCCAGAGTTTGCCGTCCAAGCAGCCTCGTCTCGGC GCGCAGTGTCTGTGTCCGTCCTCTACCAGCGCCTTGGCTGAGCGGAGTCGTGCGGTTGGT GGGGGAGCCCTGCCCTCCTGGTTCGGCCTCCCCGCGCACTAGAACGAGCAAGTGATAATC AAGTTACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGGATCCAGCCAGTCTGAAAGTG ACTGCTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAACAAAAGATGATAGTGTGGGTG GAACTGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGAGGAGATCCAGGGATATGATG TAGAGTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCCCATCTGCTTGATGGCATTAC GAGAAGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAAAGCCTGCATCATAAAATCAA TAAGGGATGCAGGTCACAAATGTCCAGTTGACAATGAAATACTGCTGGAAAATCAACTAT TTCCAGACAATTTTGCAAAACGTGAGATTCTTTCTCTGATGGTGAAATGTCCAAATGAAG GTTGTTTGCACAAGATGGAACTGAGACATCTTGAGGATCATCAAGCACATTGTGAGTTTG CTCTTATGGATTGTCCCCAATGCCAGCGTCCCTTCCAAAAATTCCATATTAATATTCACA TTCTGAAGGATTGTCCAAGGAGACAGGTTTCTTGTGACAACTGTGCTGCATCAATGGCAT TTGAAGATAAAGAGATCCATGACCAGAACTGTCCTTTGGCAAATGTCATCTGTGAATACT GCAATACTATACTCATCAGAGAACAGATGCCTAATCATTATGATCTAGACTGCCCTACAG CCCCAATTCCATGCACATTCAGTACTTTTGGTTGCCATGAAAAGATGCAGAGGAATCACT TGGCACGCCACCTACAAGAGAACACCCAGTCACACATGAGAATGTTGGCCCAGGCTGTTC ATAGTTTGAGCGTTATACCCGACTCTGGGTATATCTCAGAGGTCCGGAATTTCCAGGAAA CTATTCACCAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAAATCCGGGAGCTGACTG CTAAAATGGAAACTCAGAGTATGTATGTAAGTGAGCTCAAACGAACCATTCGAACCCTTG AGGACAAAGTTGCTGAAATCGAAGCACAGCAGTGCAATGGAATTTATATTTGGAAGATTG GCAACTTTGGAATGCATTTGAAATGTCAAGAAGAGGAGAAACCTGTTGTGATTCATAGCC CTGGATTCTACACTGGCAAACCCGGGTACAAACTGTGCATGCGCTTGCACCTTCAGTTAC CGACTGCTCAGCGCTGTGCAAACTATATATCCCTTTTTGTCCACACAATGCAAGGAGAAT ATGACAGCCACCTCCCTTGGCCCTTCCAGGGTACAATACGCCTTACAATTCTTGATCAGT CTGAAGCACCTGTAAGGCAAAACCACGAAGAGATAATGGATGCCAAACCAGAGCTGCTTG CTTTCCAGCGACCCACAATCCCACGGAACCCAAAAGGTTTTGGCTATGTAACTTTTATGC ATCTGGAAGCCCTAAGACAAAGAACTTTCATTAAGGATGACACATTATTAGTGCGCTGTG AGGTCTCCACCCGCTTTGACATGGGTAGCCTTCGGAGGGAGGGTTTTCAGCCACGAAGTA CTGATGCAGGGGTATAGCTTGCCCTCACTTGCTCAAAAACAACTACCTGGAGAAAACAGT GCCTTTCCTTGCCCTGTTCTCAATAACATGCAAACAAACAAGCCACGGGAAATATGTAAT ATCTACTAGTGAGTGTTGTTAGAGAGGTCACTTACTATTTCTTCCTGTTACAAATGATCT GAGGCAGTTTTTTCCTGGGAATCCACACGTTCCATGCTTTTTCAGAAATGTTAGGCCTGA AGTGCCTGTGGCATGTTGCAGCAGCTATTTTGCCAGTTAGTATACCTCTTTGTTGTACTT TCTTGGGCTTTTGCTCTGGTGTATTTTATTGTCAGAAAGTCCAGACTCAAGAGTACTAAA CTTTTAATAATAATGGATTTTCCTTAAAACTTCAGTCTTTTTGTAGTATTATATGTAATA TATTAAAAGTGAAAATCACTACCGCCTTGTGCTAGTGCCCTCGAGAAGAGTTATTGCTCT AGAAAGTTGAGTTCTCATTTTTTTAACCTGTTATAGATTTCAGAGGATTTGAACCATAAT CCTTGGAAAACTTAAGTTCTCATTCACCCCAGTTTTTCCTCCAGGTTGTTACTAAGGATA TTCAGGGATGAGTTTAAACCCTAAATATAACCTTAATTATTTAGTGTAAACATGTCTGTT GAATAATACTTGTTTAAGTGTTCCTTCTGCCTTGCTTACTTATTTCCTTGAGGTTACGAA GTAGCNTCTTCCCCAGAGTTTATAATGCTGAGAACCACGTGGATACCAACTGCTCATTGT TATGCTATGTAACCCTTTTTGTCTATTCAGTGCAGAGTGAATTTCACAGCTCTGCATATG TCTTCATTTGTTTAATGCTTACAAGACAGGAGATGCACACATACAATCAGCAACATAAAA ATTANAAGTGACCCAAGTAGTCAGCGCATGTGGCATCTCATTGGTGGTGACAGAAGCTAT GTGAGCCAGANGTTTTCAGCTCTXXXXXXXXXXXXXXXXXXXXXXXXXCAGCTCAAAAAA GGAAATGATATTTAAAAGCTTCCTGGTCAGATTTCTATTAAAAGCACTGGCTGTGCATTA GATACAAAGAGGAGTCATTTCCTGCCTTGGTGATACTATTTTTTTCTACTAACTCAAGAG TCTTTATTAAAAAAAAAGTTGTTTTGCCTAATTTCAGCTTTTAGCAAGCTTCCCATCTGT AAAATGATTTGGACCAGATATTTCTAGAGTCCCCTCCAGCCATAACATTCTGTCTCAAAT TAAGTTCCAACCAGCAGAACACTGACAATACTTAGGAAAGTATTTTGCCAGTATAAAATG TCTTTAACTTACTCTTTGCTGACACTGATACTTTCCTCTAATTTAGTGTCTATCAGCTGG GTCACATCTTAAGTAAAATGAGCAATTTTAACCCCCAACATTTGGCATTTTGTCATAAAC CAGCCAGTTATTTTATGCTGGTCATTCATCTTGACTACAAAGTAGAATAGTCAAGCTGTC ATTCCAAATAGAAAACTTTTTACTTCAATCAGAATTAAGCCTTAACCTGGAAAGTTGGTT TCTTCCTTACATTTTCCCAATCTCCTACTCTATTCTTAAACATGCTAGTTTCACTCAGTT GGGTATACAAGCCTTTGGGCTTTATGTTGTATGTTACTAACCACCTTTTACCATATTTAT CTTTTGGCATCATTCTGGGACATTGCTAAATTAAAAAAGAAATTGTTTCCACTTTTTTCT GGAGATGTTCAACTAAAGGTTGTTTTGTTTTGTTTTTTGTTTTGAGACAGTCTCACCACT GCACTCCAGTCTGGGCAACAGAGCGAGACTCCTTCTCAAAAAAAAAAAAAAAAAAAAAAC TCGAC >OriGene 5' read for NM_004620 unedited
GACTCACTATAGGGCGGCCGCGAATTCGCACGAGGAAGCAGTGGCGTCCGCAGCTGGGGC TTGGCCTGCGGGCGGCCAGCGAAGGTGGCGAAGGCTCCCACTGGATCCAGAGTTTGCCGT CCAAGCAGCCTCGTCTCGGCGCGCAGTGTCTGTGTCCGTCCTCTACCAGCGCCTTGGCTG AGCGGAGTCGTGCGGTTGGTGGGGGAGCCCTGCCCTCCTGGTTCGGCCTCCCCGCGCACT AGAACGAGCAAGTGATAATCAAGTTACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGG ATCCAGCCAGTCTGAAAGTGACTGCTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAAC AAAAGATGATAGTGTGGGTGGAACTGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGA GGAGATCCAGGGATATGATGTAGAGTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCC CATCTGCTTGATGGCATTACGAGAAGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAA AGCCTGCATCATAAAATCAATAAGGGNATGCAGGTCACAAATGTCCAGTTGACAATGAAA TACTGCTGGAAAATCAACTATTTCCAGACAATTTTGCAAAACGTGAGATTCTTTCTCTNG ATGGTGAAATGTCCAATGAAAGGTTGTTTGCACAAGATGGAACTGAGACATCTTNGAGGA TCATCAAGCACATTTGTGAGTTTGCTCTTATGGGATTGTNCCCATGCCAGCGTCCCTTCC AAAAATTCATATTATATTACATTCTGGAAAGATGTCCAGGGAACAGGGTTTCTTGTGACA CTGTGCTGCATCATGGCATTTGAGATAG >OriGene 3' read for NM_004620 unedited
GGTCTTCCTTGGCCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTGA GAAGAGTCTCGCTCTGTTGCCCAGACTGGAGTGCAGTGGTGAGACTGTCTCAAAACAAAA AACAAAACAAAACAACCTTTAGTTGAACATCTCCAGAAAAAAGTGGAAACAATTTCTTTT TTAATTTAGCAATGTCCCAGAATGATGCCAAAAGATAAATATGGTAAAAGGTGGTTAGTA ACATACAACATAAAGCCCAAAGGCTTGTATACCCAACTGAGTGAAACTAGCATGTTTAAG AATAGAGTAGGAGATTGGGAAAATGTAAGGAAGAAACCAACTTTCCAGGTTAAGGCTTAA TTCTGATTGAAGTAAAAAGTTTTCTATTTGGAATGACAGCTTGACTATTCTACTTTGTAG TCAAGATGAATGACCAGCATAAAATAACTGGCTGGTTTATGACAAAATGCCAAATGTTGG GGGTTAAAATTGCTCATTTTACTTAAGATGTGACCCAGCTGATAGACACTAAATTAGAGG AAAGTATCAGTGTCAGCAAAGAGTAAGTTAAAGACATTTTATACTGGCAAAATACTTTCC TAAGTATTGTCAGTGTTCTGCTGGTTGGAACTTAATTTGAGACAGAATGTTATGGCTGGA GGGGACTCTAGAAATATCTGGTCCAAATCATTTTACAGATGGGAAGCTTGCTAAAAGCTG AAATTANGCAAAACAACTTTNTTTTTAATAAAGACTCTTGAGTTAGTAGAAAAAAATAGT ATCACCAAAGCAGGAAATGACTCCTCTTTGTATCTAATGCACAGCCAGTGCTTTTAATAG AAATCTGACCAGGAAGCCTTTAAATATACTTTCCCTTTTTTGAGCTGGGGGCGTGGAGAT AAATTGTTTTGTGGCAACACTTAATT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004620 |
| Insert Size | 4470 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004620.2, NP_004611.1 |
| RefSeq Size | 2515 bp |
| RefSeq ORF | 1569 bp |
| Locus ID | 7189 |
| UniProt ID | Q9Y4K3 |
| Domains | zf-TRAF, RING, MATH |
| Protein Families | Druggable Genome |
| Protein Pathways | Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway, Ubiquitin mediated proteolysis |
| Gene Summary | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis
,Li, C;Miao, R;Liu, S;Wan, Y;Zhang, S;Deng, Y;Bi, J;Qu, K;Zhang, J;Liu, C;,
Oncotarget
,PubMed ID 28404923
[TRAF6]
|
|
JBC Papers in Press. Published on December 11, 2014 as Manuscript M114. 591420
,Park, H;Huang, X;Lu, C;Cairo, MS;Zhou, X;,
JBC Papers in Press
[TRAF6]
|
|
miR-146a and miR-146b Regulate Human Dendritic Cell Apoptosis and Cytokine Production by Targeting of TRAF6 and IRAK1
,Park, H;Huang, X;Lu, C;Cairo, MS;Zhou, X;,
J. Biol. Chem.
,PubMed ID 25505246
[TRAF6]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219528 | TRAF6 (Myc-DDK-tagged)-Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2 |
CNY 3,888.00 |
|
| RC219528L1 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2, Myc-DDK-tagged |
CNY 6,288.00 |
|
| RC219528L2 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC219528L3 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2, Myc-DDK-tagged |
CNY 6,288.00 |
|
| RC219528L4 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2, mGFP tagged |
CNY 6,288.00 |
|
| RG219528 | TRAF6 (tGFP-tagged) - Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2 |
CNY 4,370.00 |
