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HDAC3 (NM_003883) Human Untagged Clone
CAT＃: SC112704
HDAC3 (untagged)-Human histone deacetylase 3 (HDAC3)
CNY 3,656.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HD3; KDAC3; RPD3; RPD3-2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC112704 sequence for NM_003883 edited (data generated by NextGen Sequencing)
ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCT GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT CTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAGCATGACATGTGCCGC TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTC TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC AAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTAC CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC CCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC GTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATC AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCT CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTT GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC CGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT GAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAG ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT GAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT GACAAGGAAAGCGATGTGGAGATTTAA Clone variation with respect to NM_003883.3 165 a=>g >OriGene 5' read for NM_003883 unedited
NNNCCTGTCANAAATTGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACCAGGCCGC GGGCGGCGGGCGGCGGAGGTGCGGGGCCTGCTCCCGCCGGCACCATGGCCAAGACCGTGG CCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCTGGACACCCTATGAAGC CCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGTCTCTATAAGAAGATGA TCGTCTTCAAGCCATACCAGGCCTCCCAGCATGACATGTGCCGCTTCCACTCCGAGGACT ACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGCTTCACCAAGAGTCTTA ATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTCTTTGAGTTCTGCTCGC GTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAACAAGATCTGTGATATTG CCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAGGCCTCTGGCTTCTGCT ATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTACCACCCTCGGGTGCTCT ACATTGACATTGACATCCACCATGGTGACGGNGTTCAAGAAGCTTTCTACCTCACTGACC GNGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTCCCTGGCACAGGTGACA TGTATGAAGTCGGNGCAGAGAGTGGCCGCTACTACTGTCTGAACGTGCCCCTGCGGNATG GCATTGATGACCAGAGNTACAAGCACCTTTTCCAGCCGGNTATCAACCAGNTAGTGGACT TCTACCAACCCACGTGCATTGTGCTTCAGTGTGGAGCTGACTCTCTGGCCTC >OriGene 3' read for NM_003883 unedited
CCAAAAGTGAGTTTCAGACATTTTCATATCCTCCCCACACTTGAAAACATACTTCCCATC ATCTGGGATTCAGGTGTTAGGGAGCCAGAGCCCCTTCCAAATCTCTCTCTCTTCATCTTC CCTGGAAGCAAGGGGAGGAAGAAGTCAGAACCCAGAGGATGAGGTANNTANAGCAATCTC AGTCCTTGTCTACCCGTTCATCCCTCAAAAATCTCTGGGTTCGAGGGAAGCAGGGAAGAA ATAAGGGGCAAGGGGGGCTAGGGACTGGCCTCCAGGGCCCACTGCCAATAATGTCCCAGA TAGCTATCCTTGTCTGTATCTCATCCCTAATAGGTACCATTGTCAGGCCTTGGGAGAGAG AGGAAAAGCAGGTAGATGGTTCGAGAACCAAATGTGGTCTCCAGACTCTTTCCCAGAGTC AGCAAAAGCCCTGGGGTGAACCCCAGGACTCTAGGAGCCACTCCTTTTCCCTCCAGCCCA ACCAAGAGGTGAAAAGAAATTCCTTGGGACACAGCATCCCAAGCCACTCTTAAATCTCCA CATCGCTTTCCTTGTCATTGTCATGGTCTCCATCATAGAACTCATTGGGTGCCTCTGGCC TGCTATAGTTCTCCTCAGGACCCCTCTCCTCTGCATCAGCCTCATCAGTCCTGTCATAGG TCAGGAGGTCTGCAGGCACGTCATGAATCTGGACACTAGGTGCATGGTTCAGCATCTTCA GGTTTTCAAAGATTGTCTGGCGGATCTGGTCCAGATACTGGCGTGAGTTCTGATTCTCGA TGCCGGTGCTGACATCTGGATGAAGTGTGAAGTCTGGGGCAAAGTACTCGAAGTATTCCC TAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003883 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003883.2, NP_003874.2 |
| RefSeq Size | 1955 bp |
| RefSeq ORF | 1287 bp |
| Locus ID | 8841 |
| UniProt ID | O15379 |
| Domains | Hist_deacetyl |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Aggregate-prone R120GCRYAB triggers multifaceted modifications of the Thioredoxin System
,Banerjee Mustafi, S;Grose, JH;Zhang, H;Pratt, GW;Sadoshima, J;Christians, E;Benjamin, I;,
Diabetes, Aug 2013; 62: 2834 - 2842.
,PubMed ID 24180415
[HDAC3]
|
|
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
,null,
Molecular Neurodegeneration
,PubMed ID 24160175
[HDAC3]
|
|
Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells
,null,
The American Journal of Pathology
,PubMed ID 21945803
[HDAC3]
|
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Resources
Other Versions
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| RC200605 | HDAC3 (Myc-DDK-tagged)-Human histone deacetylase 3 (HDAC3) |
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| RC200605L1 | Lenti ORF clone of Human histone deacetylase 3 (HDAC3), Myc-DDK-tagged |
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| RC200605L2 | Lenti ORF clone of Human histone deacetylase 3 (HDAC3), mGFP tagged |
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| RC200605L3 | Lenti ORF clone of Human histone deacetylase 3 (HDAC3), Myc-DDK-tagged |
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| RC200605L4 | Lenti ORF clone of Human histone deacetylase 3 (HDAC3), mGFP tagged |
CNY 6,056.00 |
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| RG200605 | HDAC3 (tGFP-tagged) - Human histone deacetylase 3 (HDAC3) |
CNY 5,256.00 |
