United States
Germany
Japan
United Kingdom
China
CEE (GET4) (NM_015949) Human Untagged Clone
CAT＃: SC114540
GET4 (untagged)-Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4)
CNY 2,400.00
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C7orf20; CEE; CGI-20; TRC35 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_015949, the custom clone sequence may differ by one or more nucleotides
ATGGCGGCGGCGGCGGCGATGGCCGAGCAGGAGAGCGCCCGGAACGGCGGCCGCAACCGCGGCGGCGTCC AGCGTGTGGAGGGCAAGCTGCGCGCCAGCGTCGAGAAGGGCGACTACTACGAGGCGCACCAGATGTACCG GACCCTGTTCTTCAGGTACATGTCCCAGAGCAAGCACACGGAGGCCCGGGAGCTCATGTACTCGGGAGCC CTGCTCTTCTTCAGCCATGGCCAGCAAAACAGTGCAGCAGACTTGTCCATGCTGGTCCTGGAGTCCCTGG AGAAGGCGGAAGTGGAGGTGGCTGACGAGCTGCTGGAAAATCTGGCTAAAGTGTTCAGCCTGATGGACCC CAACTCTCCTGAGCGCGTGACCTTTGTGTCCAGAGCCCTGAAGTGGTCCAGTGGGGGCTCCGGGAAGCTG GGCCACCCCCGGCTGCACCAGCTGCTGGCCCTCACCCTGTGGAAAGAACAAAACTATTGTGAGTCGAGGT ATCATTTTCTGCACTCAGCGGACGGGGAGGGCTGTGCCAACATGCTGGTGGAGTATTCCACGTCCCGCGG CTTCCGCAGCGAGGTGGACATGTTCGTGGCCCAGGCCGTGCTACAGTTTCTCTGTTTAAAAAACAAAAGT AGCGCATCGGTGGTCTTCACGACGTACACCCAGAAGCACCCGTCCATCGAGGACGGGCCTCCGTTTGTGG AGCCGCTGCTTAACTTCATCTGGTTCCTGCTGCTGGCTGTGGACGGTGGGAAGCTGACGGTGTTCACTGT GCTGTGTGAGCAGTACCAGCCATCCCTCCGGCGGGACCCCATGTACAACGAGTACCTCGACCGCATAGGA CAGCTGTTCTTCGGCGTCCCGCCCAAGCAGACGTCTTCCTACGGGGGCCTGCTCGGGAACCTTCTGACCA GCCTCATGGGCTCCTCAGAGCAGGAGGATGGGGAGGAGAGCCCCAGCGACGGCAGCCCCATCGAGCTGGA CTGA >OriGene 5' read for NM_015949 unedited
ATAGGCGGCACGCGAATTCGCACGAGGGATAGCGCCCGGAACGGCGGCCGCAACCGCGGC GGCGTCCAGCGTGTGGAGGGCAAGCTGCGCGCCAGCGTCGAGAAGGGCGACTACTACGAG GCGCACCAGATGTACCGGACCCTGTTCTTCAGGTACATGTCCCAGAGCAAGCACACGGAG GCCCGGGAGCTCATGTACTCGGGAGCCCTGCTCTTCTTCAGCCATGGCCAGCAAAACAGT GCAGCAGACTTGTCCATGCTGGTCCTGGAGTCCCTGGAGAAGGCGGAAGTGGAGGTGGCT GACGAGCTGCTGGAAAATCTGGCTAAAGTGTTCAGCCTGATGGACCCCAACTCTCCTGAG CGCGTGACCTTTGTGTCCAGAGCCCTGAAGTGGTCCAGTGGGGGCTCCGGGAAGCTGGGC CACCCCCGGCTGCACCAGCTGCTGGCCCTCACCCTGTGGAAAGAACAAAACTATTGTGAG TCGAGGTATCATTTTCTGCACTCAGCGGACGGGGAGGGCTGTGCCAACATGCTGGTGGAG TATTCCACGTCCCGCGGCTTCCGCAGCGAGGTGGACATGTTCGTGGCTCAAGCCGTGCTA CAGTTTCTCTGTTTAAAAAACAAAAGTAGCGCATCGGGTGGTCTTCACGACGTACACCCA GAAGCACCCGTCCATCGAGGACGGGCCTNCGTTTGTGGAGCCGCTGCTTAACTCATCTGG TTCCTGCTGCTGGCTGNNGGACGGTGGGAGCTNNACGTGGTCACTTGGGCTGTGTGAACA GTACCAGCATTCCTTNCGGGGGACCCATGTCCACGAGTACTCGACGCTAGGACAGCTGTT TTTTGGGGGTCCGCAAACAACGCTCTTAAAGGGGGCCTGTTGGGACCTTTGACAGCTCTG GCTCTCAAAGAGGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_015949 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_015949.2, NP_057033.2 |
| RefSeq Size | 2106 bp |
| RefSeq ORF | 984 bp |
| Locus ID | 51608 |
| UniProt ID | Q7L5D6 |
| Gene Summary | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200220 | GET4 (Myc-DDK-tagged)-Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4) |
CNY 2,400.00 |
|
| RC200220L1 | Lenti ORF clone of Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200220L2 | Lenti ORF clone of Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4), mGFP tagged |
CNY 5,890.00 |
|
| RC200220L3 | Lenti ORF clone of Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC200220L4 | Lenti ORF clone of Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4), mGFP tagged |
CNY 5,890.00 |
|
| RG200220 | GET4 (tGFP-tagged) - Human golgi to ER traffic protein 4 homolog (S. cerevisiae) (GET4) |
CNY 4,370.00 |
