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UGT1A4 (NM_007120) Human Untagged Clone
CAT＃: SC115733
UGT1A4 (untagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4)
CNY 3,984.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GNT1; hUG-BR1; HUG-BR2; UDPGT; UDPGT 1-4; UGT-1A; UGT-1D; UGT1; UGT1-01; UGT1-04; UGT1.1; UGT1.4; UGT1A; UGT1A1; UGT1A4S; UGT1D |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC115733 sequence for NM_007120 edited (data generated by NextGen Sequencing)
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGGGGCGGTG CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC TGTGCCAACGGGAAGCCACTATCTCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAA CATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCT ATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGA ACCCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGAT CTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTAT GAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGAC AATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACT TCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAAC ATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTG TTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCAC GACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTG CTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGG AAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA Clone variation with respect to NM_007120.2 471 t=>c >OriGene 5' read for NM_007120 unedited
GTCGCATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACCAGGCTGAGATGGCC AGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTCAGTGTC CAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCCTGGCTC AGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTCCTCACC CCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTATGCTGTT CCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTCTTTGAA ACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTATCTTTG GCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCACCTGAAT GCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGGNGCGGTGCTGGCT AAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTAGACTTT AAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACCAATTCA GACCACATGACATTCCTGCANAGGGTCAAGAACATGCTCTACCCTCTGGCCCTGTCCTAC ATTTGCCATACTTTTTCTGCCCCTTTATGCAGTCTTGCCTCTGAGCTTTTCAGAGAGAGT GTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGGTCCGAGGGACTTTGTGATG GACTACCCCAGCCGATCATGCCCACATGGTCTTCATGGNGGCATCACTGTGCCACGGGNA GCACTATCTCAGATTTGAGCTACTTATG >OriGene 3' read for NM_007120 unedited
NNTTCGACTTGNNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTAGA ATTATATAAATTTATTAATTTATTTTTAGTTGTAGGAAACATCAGAAAAAAATAAACTTG CCCAGCACTTCATAGCTGTATTTTGGGTTTTTATCAAATTCAGCTCCATTTGACATAAGC AATGATTATCTTCTCAAATACACCACCCACCAATTTCATAGCATCATTCTTTTTCCCCAA AGCAAGAAATCATATGCTGTTCTCAGTGCACTCCAAGCCATTCATTCATTTCACCTACAC TCTAAAGGTACAAAGCTTCCCTTCTTTAAACACACAAGGTGGCACCTATGAAGCACGACA GAGATGAGGACTGACCATTATTGGTTAAGGATCAATTGCAACCATCTGCAGAAGCCAAAA GATAAGATTAAAACTGCCATTTGCAGTAGGGGCAGCCGTGGGACCACCTTTGAATCCCGC ACTCCCAAACAGGCCATGTTTCAGAGTAAGAAAAGTAATCTAGAATGCCAGCCTGTCTGC ACGTCCTCTGAAAAATGGCACATGTCATCCTGATCAAAGACACCAGAGGGGGCACGATAC ATATTCAAATATCTTTACTGACTAGCGAGTCTATTATTTTTATTTAAGAGAATTTTTTAA AGCACTCTGGGGCTGATTAATTTATGCAAAGTATTTCCTTAATAAGAATAAAATGAATTT AACACTGATTCTGTNTTCAAGTTTGGAAATGACTACGGGAATGGTTCACAATTTTACCTT ATTTCCCACCCACTTCTCATGGGGTCTGGNATTTGTGGGCTTTCTTAACTCGCCTTTTGT GCCCCAGCATTTCCGGTAGCCATGAGCACACATTTAAAGGTGATGAAGCCACGGTAGCNC NAACGCCAAAAGAACCNATCACGTCAGGNATGTACTGGTACCAGTGAGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_007120 |
| Insert Size | 2440 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_007120.2, NP_009051.1 |
| RefSeq Size | 2374 bp |
| RefSeq ORF | 1605 bp |
| Locus ID | 54657 |
| UniProt ID | P22310 |
| Domains | UDPGT |
| Protein Families | Transmembrane |
| Protein Pathways | Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism |
| Gene Summary | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes
,Osborne, MJ;Coutinho de Oliveira, L;Volpon, L;Zahreddine, HA;Borden, KLB;,
J. Mol. Biol.
,PubMed ID 30428301
[UGT1A4]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219801 | UGT1A4 (Myc-DDK-tagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4) |
CNY 3,976.00 |
|
| RC219801L3 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC219801L4 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4), mGFP tagged |
CNY 6,376.00 |
|
| RG219801 | UGT1A4 (tGFP-tagged) - Human UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4) |
CNY 4,370.00 |
