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OATP2 (SLCO1B1) (NM_006446) Human Untagged Clone
CAT＃: SC116071
SLCO1B1 (untagged)-Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1)
CNY 7,600.00
货期*
现货
规格
| Cited in 3 publications. |
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_006446, the custom clone sequence may differ by one or more nucleotides
AACAAAATATTAACGCTTACAATTTCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGT GCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACG CCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGCCAAGCTGATCTATACATTGAATCAAT ATTGGCAATTAGCCATATTAGTCATTGGTTATATAGCATAAATCAATATTGGCTATTGGCCATTGCATAC GTTGTATCTATATCATAATATGTACATTTATATTGGCTCATGTCCAATATGACCGCCATGTTGACATTGA TTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCG TTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAAT GACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAA ACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTCCGCCCCCTATTGACGTCAATGACGGTA AATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTACGGGACTTTCCTACTTGGCAGTACATCTACGT ATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACACCAATGGGCGTGGATAGCGGTTTGAC TCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGG ACTTTCCAAAATGTCGTAATAACCCCGCCCCGTTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGT CTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGA ATTCGGCACCAGGTTGCTGTAGGATTCTAAATCCAGGTGATTGTTTCAAACTGAGCATCAACAACAAAAA CATTTGTATGATATCTATATTTCAATCATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAAC CTTCAGAGAATAAGAAAACAAGATACTGCAATGGATTGAAGATGTTCTTGGCAGCTCTGTCACTCAGCTT TATTGCTAAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAGATA TCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTGGAAATTTGCTTGTGATTGTATTTGTGA GTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGTTGTTTCATTATGGGAATTGGAGG TGTTTTGACTGCTTTGCCACATTTCTTCATGGGATATTACAGGTATTCTAAAGAAACTAATATCAATTCA TCAGAAAATTCAACATCGACCTTATCCACTTGTTTAATTAATCAAATTTTATCACTCAATAGAGCATCAC CTGAGATAGTGGGAAAAGGTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAA TATGCTTCGTGGAATAGGGGAGACTCCCATAGTACCATTGGGGCTTTCTTACATTGATGATTTCGCTAAA GAAGGACATTCTTCTTTGTATTTAGGTATATTGAATGCAATAGCAATGATTGGTCCAATCATTGGCTTTA CCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTAGATCTAAGCACTATCAGGATAAC TCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTTAATTTCCTTGTGTCTGGACTATTCTCCATTATT TCTTCCATACCATTCTTTTTCTTGCCCCAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGT CTTTGCATGTGCTGGAAACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATAT TACCAAAAATGTGACTGGTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATGTTT GTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTCAAATACGTAGAGC AACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGGGAGTCATAACCATACCTATTTTTGCAAG TGGAATGTTTTTAGGAGGATATATCATTAAAAAATTCAAACTGAACACCGTTGGAATTGCCAAATTCTCA TGTTTTACTGCTGTGATGTCATTGTCCTTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAG TTGCCGGACTAACCATGACCTATGATGGAAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTA TTGCAACTCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACTTAC ATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATAGTGTTTTACAACTGCA GTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCATTTGGGTGAATGCCCAAGAGATGA TGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATACAAGTCTTGAATTTATTTTTCTCTGCACTTGGA GGCACCTCACATGTCATGCTGATTGTTAAAATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCC ACTCAATGGTTATACGAGCACTAGGAGGAATTCTAGCTCCAATATATTTTGGGGCTCTGATTGATACAAC GTGTATAAAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCATTT TCAAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATATATTATATTAATTT ATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAAAATGGAAGTGTCATGGATGAAGC AAACTTAGAATCCTTAAATAAAAATAAACATTTTGTCCCTTCTGCTGGGGCAGATAGTGAAACACATTGT TAAGGGGAGAAAAAAAGCCACTTCTGCTTCTGTGTTTCCAAACAGCATTGCATTGATTCAGTAAGATGTT ATTTTTGAGGAGTTCCTGGTCCTTTCACTAAGAATTTCCACATCTTTTATGGTGGAAGTATAAATAAGCC TATGAACTTATAATAAAACAAACTGTAGGTAGAAAAAATGAGAGTACTCATTGTTACATTATAGCTACAT ATTTGTGGTTAAGGTTAGACTATATGATCCATACAAATTAAAGTGAGAGACATGGTTACTGTGTAATAAA AGAAAAAATACTTGTTCAGGTAATTCTAATTCTTAATAAAACAAATGAGTATCATACAGGTAGAGGTTAA AAAGGAGGAGCTAGATTCATATCCTAAGTAAAGAGAAATGCCTAGTGTCTATTTTATTAAACAAACAAAC ACAGAGTTTGAACTATAATACGAAGGCCTGAAGTCTAGCTTGGATGTATGCTACAATAATATCTGTTACT CACATAAAATTATATATTTCACAGACTTTATCAATGTATAATTAACAATTATCTTGTTTAAGTAAATTTA GAATACATTTAAGTATTGTGGAAGAAATAAAGACATTCCAATATTTGCAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAACTCGAGACTAGCTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCC GGGTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTTGCCACTCCAGTGCCCACCA GCCTTGTCCTAATAAAATTAAGTTGCATCATTTTGTCTGACTAGGTGTCCTTCTATAATATTATGGGGTG GAGGGGGGTGGTATGGAGCAAGGGGCAAGTTGGGAAGACAACCTGTAGGGCCTGCGGGGTCTATTGGGAA CCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAATCTCCGCCTCCTGGGTTCAAGCGATTCTCC TGCCTCAGCCTCCCGAGTTGTTGGGATTCCAGGCATGCATGACCAGGCTCAGCTAATTTTTGTTTTTTTG GTAGAGACGGGGTTTCACCATATTGGCCAGGCTGGTCTCCAACTCCTAATCTCAGGTGATCTACCCACCT TGGCCTCCCAAATTGCTGGGATTACAGGCGTGAACCACTGCTCCCTTCCCTGTCCTTCTGATTTTAAAAT AACTATACCAGCAGGAGGACGTCCAGACACAGCATAGGCTACCTGGCCATGCCCAACCGGTGGGACATTT GAGTTGCTTGCTTGGCACTGTCCTCTCATGCGTTGGGTCCACTCAGTAGATGCCTGTTGAATTGGGTACG CGGCCAGCTTGGCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAA GTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAG AAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCC CTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCG AGGCCGCCTCGGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAA AAAGCTCCTCGAGGAACTGAAAAACCAGAAAGTTAATTCCCTATAGTGAGTCGTATTAAATTCGTAATCA TGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCAT AAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCT TTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGC GTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGT ATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGA GCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCC CCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATA CCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTG TCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGT AGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGG ATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTA GAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTG ATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAA AAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTT AAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTT TAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCT ATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATAC GGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTT ATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTG CCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACG ATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTT GTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCA TGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCG GCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTG CTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGA TGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAA AACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTC CTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTT AGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGCGCCCTGTAGCGG CGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCC GCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGG TTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAAT AGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGA TTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTTTAACAA AATATT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006446 |
| Insert Size | 2800 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_006446.2. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006446.4, NP_006437.3 |
| RefSeq Size | 2830 bp |
| RefSeq ORF | 2076 bp |
| Locus ID | 10599 |
| UniProt ID | Q9Y6L6 |
| Domains | OATP_N, OATP_C |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo
,Green, SM;Kaipainen, A;Bullock, K;Zhang, A;Lucas, JM;Matson, C;Banks, WA;Mostaghel, EA;,
Prostate Cancer Prostatic Dis.
,PubMed ID 27645128
[SLCO1B1]
|
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Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
,Laura B. Ramsey, Gitte H. Bruun, Wenjian Yang, Lisa R. Treviño, Selina Vattathil, Paul Scheet, Cheng Cheng, Gary L. Rosner, Kathleen M. Giacomini, Yiping Fan, Alex Sparreboom, Torben S. Mikkelsen, Thomas J. Corydon, Ching-Hon Pui, William E. Evans, and Mary V. Relling,
Genome Res., Jan 2012; 22: 1 - 8.
[SLCO1B1]
|
|
Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
,Simone Leuthold, Bruno Hagenbuch, Nilufar Mohebbi, Carsten A Wagner, Peter J. Meier, and Bruno Stieger,
Am J Physiol Cell Physiol, Jan 2009; 10.1152/ajpcell.00436.2008.
[SLCO1B1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222130 | SLCO1B1 (Myc-DDK-tagged)-Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1) |
CNY 5,064.00 |
|
| RC222130L1 | Lenti ORF clone of Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC222130L2 | Lenti ORF clone of Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1), mGFP tagged |
CNY 7,464.00 |
|
| RC222130L3 | Lenti ORF clone of Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1), Myc-DDK-tagged |
CNY 7,464.00 |
|
| RC222130L4 | Lenti ORF clone of Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1), mGFP tagged |
CNY 7,464.00 |
|
| RG222130 | SLCO1B1 (tGFP-tagged) - Human solute carrier organic anion transporter family, member 1B1 (SLCO1B1) |
CNY 6,664.00 |
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