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beta 2 Adrenergic Receptor (ADRB2) (NM_000024) Human Untagged Clone
CAT＃: SC116997
ADRB2 (untagged)-Human adrenergic, beta-2-, receptor, surface (ADRB2)
CNY 5,488.00
| Cited in 6 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADRB2R; ADRBR; B2AR; BAR; BETA2AR |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC116997 representing NM_000024.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCGGCCGCGAATTCGGCACGAGGCAGGCACCGCGAGCCCCTAGCACCCGACAAGCTGAGTGTGCAGGAC GAGTCCCCACCACACCCACACCACAGCCGCTGAATGAGGCTTCCAGGCGTCCGCTCGCGGCCCGCAGAG CCCCGCCGTGGGTCCGCCTGCTGAGGCGCCCCCAGCCAGTGCGCTTACCTGCCAGACTGCGCGCCATGG GGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATGGAAGCCATGCGCCGGACCACGACGTCA CGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATGTCTCTCATCGTCCTGGCCATCG TGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAGTTCGAGCGTCTGCAGACGGTCACCAACTACT TCATCACTTCACTGGCCTGTGCTGATCTGGTCATGGGCCTAGCAGTGGTGCCCTTTGGGGCCGCCCATA TTCTTATGAAAATGTGGACTTTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCG TCACGGCCAGCATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCA AGTACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTGTCAGGCC TTACCTCCTTCTTGCCCATTCAGATGCACTGGTACAGGGCCACCCACCAGGAAGCCATCAACTGCTATG CCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCCATTGCCTCTTCCATCGTGTCCTTCT ACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCCAGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGA AGATTGACAAATCTGAGGGCCGCTTCCATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGG GGCATGGACTCCGCAGATCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCA TCATGGGCACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGATA ACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGTTTCAATCCCC TTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTGTGCCTGCGCAGGTCTTCTT TGAAGGCCTATGGCAATGGCTACTCCAGCAACGGCAACACAGGGGAGCAGAGTGGATATCACGTGGAAC AGGAGAAAGAAAATAAACTGCTGTGTGAAGACCTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTA CTGTGCCTAGCGATAACATTGATTCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTATAAAGCA GTTTTTCTACTTTTAAAGACCCCCCCCCGCCCAACAGAACACTAAACAGACTATTTAACTTGAGGGTAA TAAACTTAGAATAAAATTGTAAAATTGTATAGAGATATGCAGAAGGAAGGGCATCCTTCTGCCTTTTTT ATTTTTTTAAGCTGTAAAAAGAGAGAAAACTTATTTGAGTGATTATTTGTTATTTGTACAGTTCAGTTC CTCTTTGCATGGAATTTGTAAGTTTATGTCTAAAGAGCTTTAGTCCTAGAGGACCTGAGTCTGCTATAT TTTCATGACTTTTCCATGTATCTACCTCACTATTCAAGTATTAGGGGTAATATATTGCTGCTGGTAATT TGTATCTGAAGGAGATTTTCCTTCCTACACCCTTGGACTTGAGGATTTTGAGTATCTCGGACCTTTCAG CTGTGAACATGGACTCTTCCCCCACTCCTCTTATTTGCTCACACGGGGTATTTTAGGCAGGGATTTGAG GAGCAGCTTCAGTTGTTTTCCCGAGCAAAGTCTAAAGTTTACAGTAAATAAATTGTTTGACCATGCAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGC >OriGene 5' read for NM_000024 unedited
GCGGTCGAGATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCAGGCAC CGCGAGCCCCTAGCACCCGACAAGCTGAGTGTGCAGGACGAGTCCCCACCACACCCACAC CACAGCCGCTGAATGAGGCTTCCAGGCGTCCGCTCGCGGCCCGCAGAGCCCCGCCGTGGG TCCGCCTGCTGAGGCGCCCCCAGCCAGTGCGCTTACCTGCCAGACTGCGCGCCATGGGGC AACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATGGAAGCCATGCGCCGGACCACG ACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATGTCTCTCA TCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAGTTCGAGC GTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTGGTCATGG GCCTAGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACTTTTGGCA ACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGCATTGAGA CCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAGTACCAGA GCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTGTCAGGCC TTACCTCCTTCTTGCCCATTCAGATGCACTGGTACAGGGCCACCCACCAGGAAGCCATCA ACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCCATTGCCT CTTCCATCGTGTCCTTCTACGTTCCCCCTGGTGATCATGGTNCTTCGTCTACTCCAGGGT C >OriGene 3' read for NM_000024 unedited
ACCTTCAGACATCTTATTACTGTAAACTTTATACTTTGCTCGGGAAACAACTGAAGCTGC TCCTCAAATCCCTGCCTAAAATACCCCGTGTGAGCAAATAAGAGGAGTGGGGGAAGAGTC CATGTTCACAGCTGAAAGGTCCGAGATACTCAAAATCCTCAAGTCCAAGGGTGTAGGAAG GAAAATCTCCTTCAGATACAAATTACCAGCAGCAATATATTACCCCTAATACTTGAATAG TGAGGTAGATACATGGAAAAGTCATGAAAATATAGCAGACTCAGGTCCTCTAGGACTAAA GCTCTTTAGACATAAACTTACAAATTCCATGCAAAGAGGAACTGAACTGTACAAATAACA AATAATCACTCAAATAAGTTTTCTCTCTTTTTACAGCTTAAAAAAATAAAAAAGGCAGAA GGATGCCCTTCCTTCTGCATATCTCTATACAATTTTACAATTTTATTCTAAGTTTATTAC CCTCAAGTTAAATAGTCTGTTTAGTGTTCTGTTGGGCGGGGGGGGGTCTTTAAAAGTAGA AAAACTGCTTTATAGCAGTGAGTCATTTGTACTACAATTCCTCCCTTGTGAATCAATGTT ATCGCTAGGCACAGTACCTTGATGGCCCACAAAGTCTTCCGTGCCTGGGAAGTCTTCACA CAGCAGTTTATTTTCTTTCTCCTGTTCCACGTGATATCCACTCTGCTCCCCTGTGTTGCC GTTGCTGGAGTAGCCATTGCCATANGCCTTCAAAGAGACCTGCGCAGCACAGAAGCTCCT GGAAGGCATCCTNGAATCTGGGCTCCNGCAGTAGATAAGGGGATTGAAACCAGAATTGAC ATAGCCTATCCAATTGAGAAGATGTAAACTTCCNTACGATGANGTATCCTGGATCAATGC ACATGTAACGATGAAGAAGGCAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000024 |
| Insert Size | 2066 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000024.3 |
| RefSeq Size | 2015 bp |
| RefSeq ORF | 2066 bp |
| Locus ID | 154 |
| UniProt ID | P07550 |
| Domains | 7tm_1 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction |
| MW | 76.5 kDa |
| Gene Summary | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019] |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7
,Jakobs, BD;Spannagel, L;Purvanov, V;Uetz-von Allmen, E;Matti, C;Legler, DF;,
Int J Mol Sci
,PubMed ID 31137829
[beta 2 Adrenergic Receptor]
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Cell-free methods to produce structurally intact mammalian membrane proteins
,Shinoda, T;Shinya, N;Ito, K;Ishizuka-Katsura, Y;Ohsawa, N;Terada, T;Hirata, K;Kawano, Y;Yamamoto, M;Tomita, T;Ishibashi, Y;Hirabayashi, Y;Kimura-Someya, T;Shirouzu, M;Yokoyama, S;,
Sci Rep
,PubMed ID 27465719
[beta 2 Adrenergic Receptor]
|
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Divergent Label-free Cell Phenotypic Pharmacology of Ligands at the Overexpressed β2-Adrenergic Receptors
,Ferrie, AM;Sun, H;Zaytseva, N;Fang, Y;,
Sci Rep, Jan 2014.
,PubMed ID 24451999
[beta 2 Adrenergic Receptor]
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Développement de la technologie des récepteurs couplés à un canal ionique pour des études structure-fonction des récepteurs couplés aux protéines G et du canal Kir6.2
,Niescierowicz, K;,
Thesis
[beta 2 Adrenergic Receptor]
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Adenosine A2A Receptor Is Involved in Cell Surface Expression of A2B Receptor
,Kengo Moriyama and Michail V. Sitkovsky,
J. Biol. Chem., Dec 2010; 285: 39271 - 39288
[beta 2 Adrenergic Receptor]
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PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by {beta}-adrenergic receptors
,Yun Shi, Zhongying Wu, Ningren Cui, Weiwei Shi, Yang Yang, Xiaoli Zhang, Asheebo Rojas, Binh T Ha, and Chun Jiang,
Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1205-14.
[beta 2 Adrenergic Receptor]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204499 | ADRB2 (Myc-DDK-tagged)-Human adrenergic, beta-2-, receptor, surface (ADRB2) |
CNY 5,488.00 |
|
| RC204499L1 | Lenti ORF clone of Human adrenergic, beta-2-, receptor, surface (ADRB2), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204499L2 | Lenti ORF clone of Human adrenergic, beta-2-, receptor, surface (ADRB2), mGFP tagged |
CNY 5,890.00 |
|
| RC204499L3 | Lenti ORF clone of Human adrenergic, beta-2-, receptor, surface (ADRB2), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204499L4 | Lenti ORF clone of Human adrenergic, beta-2-, receptor, surface (ADRB2), mGFP tagged |
CNY 7,888.00 |
|
| RG204499 | ADRB2 (tGFP-tagged) - Human adrenergic, beta-2-, receptor, surface (ADRB2) |
CNY 7,088.00 |
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