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HDAC1 (NM_004964) Human Untagged Clone
CAT＃: SC117054
HDAC1 (untagged)-Human histone deacetylase 1 (HDAC1)
CNY 5,488.00
| Cited in 6 publications. |
Product images
CNY 1,999.00
CNY 2,630.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GON-10; HD1; KDAC1; RPD3; RPD3L1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_004964 edited
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG TTGGCCTGA >OriGene 5' read for NM_004964 unedited
TTTAGNATTTGGCTACTATCATATAGGCGGCCCGCGATTCGGCACGAGGCTGACGGTAGG GACGGGAGGCGAGCAAGATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACT ACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAA TCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATC GCCCTCACAAAGCCAATGCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAAT TCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCA ACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTG GTGGTTCTGTGGCAAGTGCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATT GGGCTGGGGGCCTGCACCATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATG ATATCGTCTTGGCCATCCTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACA TTGATATTCACCATGGTGACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGA CTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGGATATC GGGCTGGGCAAGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACCGGATTGATGACGA GTCCTATGAGGCCATTTCCAAGCCGTCATGTCCAAGGAATGGNAGAGTTCCACCCTAGTG CGGTGGGTCTACAGGGTGGCTCAGACTCCTATCTGGGGATCGGGTANGTTGCTTCATCTA ACTTCAAAGACCCGCCCG >OriGene 3' read for NM_004964 unedited
CAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATAGAAAGGGACCATTTTAT TACAAAGAGGCTCACAAAAATGAAAATAGTATCTCAAAAAGGAAACTAGACTAGCAACCT CCACCTGCAGAATTAGGAGAAGACAGACAGAGGGCAGGCAGTGTTTCTTGGCTCACTTGA GGCCAGTGGGAAGGTACTAATACAGAACCAATCTAAAAATGGCTGATGTTACTTTAGGAG CCTGAAAAAAACAGGAGATCCTTGAAGACCCAGCCACCCCTTCTAGAATGTTCAATAAGG GCACCTTTCCAAAGCTACTAAGCAGGCACTTGGCATTTCAGGAGTTTGTCTTATGGTTGC ATAAAAGTATCCCTTTCACCCAGACCTGGCACCCTTTATGGTTCAAAGTTAAGAACGGGA AGAATGGGTGGCAAGGTGGCTCCTGGAAGAGCTCACCCAGCACAGCTGCCCTGAGCTCGG GGCCTTGGTTTCTGTCCCTGGGGATATTTATATTTAATAAATTTTTATATAAATTCCCCG AGAACTAGAAAATATAAAATCTGAGGGGTTGGGGAAGAAACGTGAGGGACTCACCAGGAA GCCAGAGCTGGAGAAGTCCATTCAGGCCAACTTGACCTCCTCCTTGACCCCTTTGGCTTC TGGACTTCCCCTCCCTGGGTTTTTTCCTTCGGGAGACCTCCTTTTTCTCCTCTGGGCCTT TTCTTTTTTTATCCCCGGTTTGGACTCTTTTGGGCTTTTTTGAAGTTGGAACAATTTTTG CGGGCCCCCTTTTCTCCTTTTTATAATCGGAAAATCTTCTCTACAGGCATCCCTTTTCAA AAACACCCACCAAGTCTTGCCAGGTGCCCTTCCCCCCCACCCCTTCCTTAGGTACGGCGC CCATGATTTCCGCTTTGTCCCCCCCGTCGCGGATTTTTATGGCCCCAAACCGCCGCTTCC CCCCTGTCCATCCCCGCCGTTTCACTTATATACCCGCCCCCCCCCACTTCCATTCCCCCC C |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004964 |
| Insert Size | 2200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004964.2, NP_004955.2 |
| RefSeq Size | 2091 bp |
| RefSeq ORF | 1449 bp |
| Locus ID | 3065 |
| UniProt ID | Q13547 |
| Domains | Hist_deacetyl |
| Protein Families | Adult stem cells, Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer |
| Gene Summary | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Cytoplasmic Localization of RUNX3 Via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells
,Kang, KA;Piao, MJ;Ryu, YS;Maeng, YH;Hyun, JW;,
J. Cell. Physiol
,PubMed ID 27990641
[HDAC1]
|
|
AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
,Incani, F;Serra, M;Meloni, A;Cossu, C;Saba, L;Cabras, T;Messana, I;Rosatelli, M;,
J. Biomed. Sci.
,PubMed ID 25158603
[HDAC1]
|
|
Stimulation of Histone Deacetylase Activity by Metabolites of Intermediary Metabolism
,Maria Vogelauer, Abigail S. Krall, Matthew A. McBrian, Jing-Yu Li, and Siavash K. Kurdistani,
J. Biol. Chem., Sep 2012; 287: 32006 - 32016.
[HDAC1]
|
|
Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells
,null,
The American Journal of Pathology
,PubMed ID 21945803
[HDAC1]
|
|
A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
,Sohee Hong, Assia Derfoul, Lucilia Pereira-Mouries, and David J. Hall,
FASEB J, Jun 2009; 10.1096/fj.09-133215.
[HDAC1]
|
|
Identification of Cellular Proteins That Maintain Retroviral Epigenetic Silencing: Evidence for an Antiviral Response
,Andrey Poleshko, Ivan Palagin, Rugang Zhang, Pamela Boimel, Carolyn Castagna, Peter D. Adams, Anna Marie Skalka, and Richard A. Katz,
J. Virol., Mar 2008; 82: 2313 - 2323.
[HDAC1]
|
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Resources
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| RC201745L3 | Lenti ORF clone of Human histone deacetylase 1 (HDAC1), Myc-DDK-tagged |
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| RG201745 | HDAC1 (tGFP-tagged) - Human histone deacetylase 1 (HDAC1) |
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